WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article Effect of Marination on the Formation of Polycyclic Aromatic Hydrocarbons in Grilled Vegetables(Wiley, 2025) Kacmaz Ozcetin, Sibel; Artok, LeventThe effect of marination on the formation of polycyclic aromatic hydrocarbons (PAH) in charcoal-grilled vegetables was studied. Various marinade ingredients, including apple cider vinegar, red grape vinegar, lemon juice, garlic powder, black pepper, and the food additive tert-butylhydroquinone (TBHQ) were applied to vegetable samples before charcoal grilling. The total phenolic content (TPC) and total antioxidant capacity (TAC) of each marinade ingredient were assessed for their contribution to PAH inhibition. A substantial decrease in PAH4 formation was observed in marinated vegetables. Red grape vinegar exhibited the strongest average inhibitory effect on total PAH4 formation (75%), followed by apple vinegar (68%), lemon juice (52%), garlic powder (34%), and black pepper (30%). Additionally, the TBHQ (67%) demonstrated a strong inhibitory effect, reducing total PAH4 formation by 67%. These findings offer valuable insights for reducing PAH levels in grilled vegetables and preventing their formation.Article Citation - WoS: 2Citation - Scopus: 1The Future of European Regional Inequalities: Box-Cox Transformed Arma Process Trend Smoothing (Bats) Forecasting(Wiley, 2025) Duran, Hasan Engin; Elburz, Zeynep; Cifci, Burcu DegerliThe vast majority of the empirical studies on regional economic inequalities has analyzed the past evolutions, while the future trajectories are often ignored. Despite, no methods exist to predict the future precisely, it is worthwhile to shed light on the prospective tendencies in order to plan and formulate the policies at the present time. The current study addresses the following questions; Will regional convergence continue in Europe? Which regions will become more prosperous? What are the future determinants of regional growth? Our dataset covers 236 NUTS-2 regions belonging to the 28 European Countries for the period 2000-2022. In terms of methodology, we use a nonlinear forecasting technique BATS ("Box-Cox Transformation, ARMA errors, Trend and Seasonal Components") model and Spatial Durbin Regressions along with explorative maps and descriptive statistics. As an outcome of the analyses, we obtained several remarkable results. First, regional inequalities are expected to widen by 2050 indicating the evidence of regional divergence. Second, spatial poles of prosperity are likely to change substantially. Most of the regions belonging to the countries in the "Mediterranean Basin" are predicted to remain relatively backward while many Eastern European regions are expected to rise in prosperity. Northern and Central European regions are likely to keep their prosperous position. Third, several crucial determinants of future growth patterns are detected. It appeared that younger demographic profile, industrialization and cohesion policies (particularly for CEE regions) have become key factors of future growth performance.Article Citation - WoS: 4Citation - Scopus: 3Unveiling Bone and Dental Regeneration Potential of Quince Seed Mucilage-Nanohydroxyapatite Scaffolds in Rabbit Mandibles(Wiley, 2025) Genc, Cigdem Cetin; Yilmaz-Dagdeviren, Hilal Deniz; Deniz, Yesim; Derkus, Burak; Degirmenci, Alpin; Arslan, Yavuz EmreDonor-side morbidity of autografting for maxillofacial region defect regeneration has directed attention to bioengineered scaffolds. Composite scaffolds that mimic the bone extracellular matrix (ECM) are the potential candidates for defect reconstruction. Herein, a plant-based regenerative hydrogel, quince seed mucilage (QSM), was enriched with the nanohydroxyapatite (nHAp) particles to construct composite scaffolds (QSM/nHAp). The emerging scaffold is able to induce cellular spheroid formation and regenerate the critical-sized bilateral mandibular defects in rabbits. The macroscopic observations, histochemical (HC) and immunohistochemical (IHC) stainings, mu-computer tomography (CT) scanning, quantitative real time-polymerase chain reaction (qRT-PCR) analyses, and scanning electron microscopy (SEM) imaging revealed that all QSM/nHAp scaffolds were swelled with host blood, filled the whole cavity, and sustained cellular infiltration without adverse reactions. The gradual biodegradation profile of the scaffolds improved bone regeneration by releasing nHAp particles from the scaffold. Strikingly, co-development of dental and bone regeneration was observed for all QSM/nHAp groups beginning after day 21. Moreover, QSM/nHAp scaffolds induced expression (> 2-fold) of bone and dental-related gene and protein expressions at the grafted area and sustained a proper platform for maxillofacial remodeling. Therefore, we strongly believe that such biocompatible plant-based constructs, compared with conventional medical devices used in maxillofacial surgery, could support and induce simultaneous bone and dental regeneration due to the intrinsic dynamics of the material.Article Regression Analysis of Material Properties and Hardness of Dense Boron Carbide(Wiley, 2025) Toksoy, M. Fatih; Haber, Richard A.Material properties directly affect the final performance of the produced articles. This study aims to establish a correlation between materials properties and hardness of boron carbide samples. Ten different boron carbide powders were sintered to high densities by spark plasma sintering, and material properties (grain size, density, stoichiometry, and free carbon) were analyzed. Hardness tests were conducted on these samples. All experimental procedures were completed by a single operator, and the same instruments were used for all the samples. Multiple linear regressions using the ordinary least squares method in SPSS were carried out to identify the relationship between hardness and material properties. Analyses showed density is the most dominant property, surpassing any other parameter. Grain size became more dominant at higher densities (>99%) and affected hardness results. Both grain size and density are the result of the starting powder and the densification procedure. This study showed that 80% of the hardness variation can be explained by this model.Conference Object Investigation of the role of Wnt/β-catenin signaling in development of Alzheimer's disease in a zebrafish model of mmyloid-β toxicity(Wiley, 2024) Nazlı, Dilek; Ipekgil, D.; Poyraz, Y. K.; Catak, B.; Sahin, E. Turhanlar; Özhan, GüneşThe Wnt/β-catenin signaling pathway, an evolutionarily conserved and pivotal pathway associated with synapse formation in adulthood, plays a crucial role in Alzheimer's disease (AD). AD, marked by various pathologies, is primarily linked to the accumulation of extracellular beta-amyloid plaques. The interplay between this accumulation and disruptions in the Wnt/β-catenin signaling pathway triggers synaptic degeneration, resulting in synaptic dysfunction and AD progression. In this study, we modeled AD induced by the Aβ42 peptide using adult transgenic (6XTCF) zebrafish. To establish the zebrafish AD model, we employed cerebroventricular microinjection (CVMI) with the Aβ42 peptide. Fish, anesthetized prior to CVMI, were positioned on a stable platform, and the Aβ42 peptide was injected into the telencephalon region of the brain by a capillary needle. Brain samples were collected on 1, 3, 4, 7, and 14 days post-CVMI (dpi) to analyze changes in Aβ42 peptide accumulation, the immune system response, synaptic degeneration, apoptosis, and the expression of genes related to proliferation using qPCR and immunofluorescent staining. To examine the role of the Wnt/β-catenin signaling pathway in the molecular mechanism of AD development, fish exhibiting high levels of regeneration on days 7 and 14 were treated with the IWR-1 drug, which inhibits the Wnt/β-catenin signaling by stabilizing the Axin2 protein, thereby suppressing the regenerative response. Our results revealed that the AD model manifested on 3dpi, with the regenerative response reaching its peak on 7dpi and 14dpi. Treatment with IWR-1 resulted in increased Aβ42 accumulation, accelerated synaptic degeneration, and elevated cell deaths in fish where the Wnt signaling pathway was inhibited. In conclusion, our adult zebrafish AD model is poised to elucidate the molecular mechanisms connecting the Wnt signaling pathway and AD, thereby contributing to the development of alternative therapeutic approaches for AD patients.Article Secrecy performance of full-duplex space-air integrated networks in the presence of active/passive eavesdropper, and friendly jammer(Wiley, 2024) Buyuksar, Ayse Betul; Erdoğan, Eylem; Altunbas, IbrahimIn this paper, a full-duplex (FD) space-air ground integrated network (SAGIN) system with passive and active eavesdroppers (PE/AE) and a friendly jammer (FJ) is investigated. The shadowing side information (SSI)-based unmanned aerial vehicle relay node (URN) selection strategy is considered to improve signal-to-interference plus noise power ratio (SINR) at the ground destination unit. To quantify the secrecy performance of the considered scenario, outage probability (OP), interception probability (IP), and transmission secrecy outage probability (TSOP) are investigated in the presence of FJ and PE/AE. The results have shown that aerial AE is an important threat since it can severely degrade the OP of the main transmission link. Furthermore, the FJ can decrease the IP of the eavesdropper by causing interference with the cost of power consumption of URNs. Simulations are performed to verify the theoretical findings.Article Citation - WoS: 1Citation - Scopus: 1Application of a Size Measurement Standard for Data Warehouse Projects(Wiley, 2024) Unlu, Hueseyin; Yueruem, Ozan Rasit; Yildiz, Ali; Demirors, OnurMethodologyIn this research, we conducted a case study to establish a foundation for size measurement and effort estimation in DWH projects. We first applied a productivity-based estimation approach using linear regression with the ISBSG repository to assist organizations without historical data. We then evaluated various machine learning algorithms to improve estimation accuracy. Finally, we tested a combined model that integrates both approaches for estimating effort in external projects.ResultsUsing the ISBSG dataset, linear regression models based on productivity achieved a Mean Magnitude of Relative Error (MMRE) of 0.285. Machine learning algorithms improved accuracy by 22.81%, reducing the MMRE to 0.220. The final model, applied to external projects, yielded MRE values between 0.010 and 0.245.ConclusionThe ISBSG repository is a valuable resource for effort estimation in DWH projects. Combining productivity-based estimation with machine learning enhances accuracy and predictive performance, making it a more reliable approach than traditional models.Article Citation - WoS: 1Citation - Scopus: 1Fatigue Assessment of Copper-Brazed Stainless-Steel Joints for Plate Heat Exchangers(Wiley, 2025) Hayta, Yigit; Kandemir, SinanCyclic pressures can cause fatigue failure in the brazed joints and plates of the plate heat exchangers (PHEs). This study examines the fatigue behavior of PHEs made from 316L and 304L steels brazed with copper foils employing strain-controlled fatigue tests to explore if 304L could replace 316L in the existing production line for cost reduction. Fatigue tests were conducted at four different load levels with a stress ratio of zero and a frequency of 5 Hz. Finite Element Analysis was used to assess strain distribution and estimate PHE lifespan based on generated strain versus number of cycles to failure curves. The microstructural analysis revealed that copper diffuses more easily into 316L than 304L, and using 50 mu m thick foil causes more defects compared with 100 mu m foil. It was shown that 316L joints have a significantly increased fatigue life compared with 304L. Both 316L and 304L met the 15-year lifetime requirement set by manufacturers.Article Phenotypically Plastic Drug-Resistant Chronic Myeloid Leukaemia Cell Line Displays Enhanced Cellular Dynamics in a Zebrafish Xenograft Model(Wiley, 2024) Baykal, Seda; Yuce, Zeynep; Ozhan, GunesUnderstanding the mechanisms by which cancer cells switch between different adaptive states and evade therapeutic interventions is essential for clinical management. In this study, the in vivo cellular dynamics of a new chronic myeloid leukaemia cell line displaying altered phenotype and resistance to tyrosine kinase inhibitors were investigated in correlation with their parental cells for invasiveness/metastasis, angiogenic potential and population kinetics. We showed that the cells exhibiting drug resistance and plastic phenotype possess an increased capacity for invasion compared to their parental cells, that exposure to imatinib mesylate has the potential to enhance cellular motility and that in a leukaemic cell population, even a minority of plastic cells exhibit improved migratory ability. Furthermore, we show that these plastic cells have angiogenic and extravasation potential. The present study provides significant insights into the cellular dynamics displayed by a TKI-resistant, phenotypically plastic CML cell line, using a zebrafish (Danio rerio) xenograft model.Article Citation - WoS: 4Citation - Scopus: 5Near-Infrared Emissive Super Penetrating Conjugated Polymer Dots for Intratumoral Imaging in 3d Tumor Spheroid Models(Wiley, 2024) Karabacak, Soner; Coban, Basak; Yildiz, Ahu Arslan; Yildiz, Umit HakanThis study describes the formation of single-chain polymer dots (Pdots) via ultrasonic emulsification of nonionic donor-acceptor-donor type (D-A-D) alkoxy thiophene-benzobisthiadiazole-based conjugated polymers (Poly BT) with amphiphilic cetyltrimethylammonium bromide (CTAB). The methodology yields Pdots with a high cationic surface charge (+56.5 mV +/- 9.5) and average hydrodynamic radius of 12 nm. Optical characterization reveals that these Pdots emit near-infrared (NIR) light at a maximum wavelength of 860 nm owing to their conjugated polymer backbone consisting of D-A-D monomers. Both colloidal and optical properties of these Pdots make them promising fluorescence emissive probes for bioimaging applications. The significant advantage of positively charged Pdots is demonstrated in diffusion-limited mediums such as tissues, utilizing human epithelial breast adenocarcinoma, ATCC HTB-22 (MCF-7), human bone marrow neuroblastoma, ATCC CRL-2266 (SH-SY5Y), and rat adrenal gland pheochromocytoma, CRL-1721 (PC-12) tumor spheroid models. Fluorescence microscopy analysis of tumor spheroids from MCF-7, SH-SY5Y, and PC-12 cell lines reveals the intensity profile of Pdots, confirming extensive penetration into the central regions of the models. Moreover, a comparison with mitochondria staining dye reveals an overlap between the regions stained by Pdots and the dye in all three tumor spheroid models. These results suggest that single-chain D-A-D type Pdots, cationized via CTAB, exhibit long-range mean free path of penetration (approximate to 1 mu m) in dense mediums and tumors. The single chain near infrared (NIR) emissive Pdots with high cationic surface charge enable penetration in dense medium such as tumor spheroids. Both colloidal and optical properties of Pdots make them promising fluorescent probe in bioimaging. image