WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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Now showing 1 - 10 of 265
  • Article
    Citation - WoS: 2
    Citation - Scopus: 3
    Evaluation of Hydro-Geochemical Processes Controlling Groundwater Quality in Balkh Center (Mazar-e-Sharif) Northern Afghanistan
    (Elsevier, 2025) Farahmand, Asadullah; Zaryab, Abdulhalim; Ameri, Nasrullah; Ali, Shakir; Eqrar, Mohammad Naim
    Background: Groundwater in Afghanistan stands as the predominant water source employed for potable consumption, household utilization, irrigation, and industrial applications. Major cities of Afghanistan are largely dependent on groundwater resources. However, the groundwater quality of major cities in Afghanistan, including Mazar-e-Sharif city was not investigated in detail. Objective: This study aims to conduct a comprehensive analysis of the hydrochemical characteristics of the Mazare-Sharif groundwater, identify the factors influencing groundwater quality, and evaluate the groundwater contamination sources. Methods: A total of 18 groundwater samples were collected during the dry season (June 2020) and analyzed for various physico-chemical parameters. Methods such as multivariate statistical analyses, geochemical modeling, water quality index (WQI), and spatial distribution of groundwater quality were employed to evaluate the hydro-geochemistry of the study area. Results: The results reveal that 1) The prevailing groundwater within the study area is predominantly characterized by Na-(Ca)-HCO3 and Ca-(Mg)-SO4 water types. 2) Physicochemical variables such as NO3-, F-, TDS, and SO42-exceeded the World Health Organization (WHO) safe limits in many wells. 3) Hydro-geochemical processes such as silicate weathering, cation exchange, and gypsum dissolution controls the groundwater chemistry. 4) Cl/ Br ratios reveal, that high salinity may originate from evaporitic lacustrine and evaporite deposits and found to be localized in nature. 5) The Water Quality Index (WQI) classification suggests that approximately 60 % of the groundwater samples fall into poor to very poor water quality categories, highlighting substantial public health concerns. Major contaminants like nitrate and fluoride were found to be higher than the safe limit in nearly half of the samples. Conclusion: The findings of this study hold value for decision-makers in formulating a proficient strategy for the management of groundwater resources in Mazar-e-Sharif City in achieving the UN sustainable goal (SDG) of providing sustainable water for all. Furthermore, new advanced techniques like environmental isotopes should be analyzed to evaluate groundwater hydro-chemical evolution in the future to enhance our understanding.
  • Article
    Citation - WoS: 7
    Citation - Scopus: 6
    Polymeric Biomaterials for Periodontal Tissue Engineering and Periodontitis
    (Royal Soc Chemistry, 2024) Yuruk, Gizem; Demir, Yagmur Damla; Vural, Sevra; Kehr, Nermin Seda
    The periodontium is one of the most complex tissues in the body because its structure is formed by a hierarchical combination of soft and hard tissues. Due to its complex architecture, the treatment and regeneration of damaged periodontal tissue caused by diseases is still a challenge in biomedicine. The most common disease of the periodontium is periodontitis, which occurs when the periodontium becomes infected and inflamed as a bacterial biofilm forms in the mouth. Recently, various biocompatible biomaterials made of natural and synthetic polymers have been developed for periodontal tissue regeneration or treatment due to their superior properties such as controlled drug and bioactive molecule delivery, mimicking the 3D network of tissue, biocompatibility, antibacterial and mechanical properties. In particular, biomaterials designed for drug delivery, such as hydrogels, scaffolds, films, membranes, micro/nanoparticles and fibers, and additively manufactured biomaterials have undergone in vitro and in vivo testing to confirm their potential clinical utility in periodontal regeneration and periodontitis treatment. This review explores recent advances in the use of biomaterials for the prevention and/or treatment of periodontal regeneration and periodontitis. Specifically, it emphasizes advancements in drug/biomolecule delivery and the use of additively manufactured biomaterials for addressing periodontal issues.
  • Article
    Gypsophila Eriocalyx Roots Inhibit Proliferation, Migration, and Tgf-Β Signaling in Melanoma Cells
    (Walter de Gruyter GmbH, 2025) Azbazdar, Yagmur; Ozhan, Gunes; Helvacioglu, Selin
    Objectives: Melanoma is a highly malignant and serious form of skin cancer. In addition to the standard treatments, complementary approaches, including phytotherapy, are also used to alleviate symptoms and improve patient well- being. This study aims to investigate the anticancer effects of Gypsophila eriocalyx (GE), an endemic species from Türkiye, on melanoma cells. We set out to determine the efficacy of GE in inhibiting melanoma cell proliferation, migration, and growth, and to explore its underlying mechanisms. Methods: We examined the impact of GE on the prolifera- tion of two melanoma cell lines, Malme-3M and SK-MEL-28, and assessed its developmental toxicity in zebrafish em- bryos. Next, we evaluated GE’s influence on colony forma- tion and wound healing in melanoma cells, as well as its ability to induce apoptosis and affect the TGF-β/Smad signaling pathway, by measuring pathway reporter activity and target gene expression. Results: GE inhibited cell proliferation in melanoma cell lines at concentrations 104 to 488 times lower than those required for normal non-malignant L929 fibroblast cells. In zebrafish embryos, GE demonstrated developmental toxicity only at concentrations above 50 μg/mL. GE treatment significantly impaired the colony formation and wound healing abilities of melanoma cells, indicating reduced pro- liferation and migration. Moreover, GE induced apoptosis in melanoma cells and inhibited the TGF-β/Smad signaling pathway, as evidenced by decreased pathway reporter activity and target gene expression. Conclusions: This study highlights the potential of GE as a novel therapeutic agent in melanoma treatment by demon- strating its ability to inhibit tumor growth and progression
  • Review
    Citation - WoS: 1
    Citation - Scopus: 2
    Organ-On Platforms for Drug Development, Cellular Toxicity Assessment, and Disease Modeling
    (Tubitak Scientific & Technological Research Council Turkey, 2024) Khurram, Muhammad Maaz; Cinel, Gokturk; Yesil Celiktas, Ozlem; Bedir, Erdal
    Organs-on-chips (OoCs) or microphysiological platforms are biomimetic systems engineered to emulate organ structures on microfluidic devices for biomedical research. These microdevices can mimic biological environments that enable cell-cell interactions on a small scale by mimicking 3D in vivo microenvironments outside the body. Thus far, numerous single and multiple OoCs that mimic organs have been developed, and they have emerged as forerunners for drug efficacy and cytotoxicity testing. This review explores OoC platforms to highlight their versatility in studies of drug safety, efficacy, and toxicity. We also reflect on the potential of OoCs to effectively portray disease models for possible novel therapeutics, which is difficult to achieve with traditional 2D in vitro models, providing an essential basis for biologically relevant research.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    Investigation of Flow and Heat Transfer Performance of Gyroid Structure as Porous Media
    (Turkish Soc Thermal Sciences Technology, 2024) Genc, Alper Mete; Karadeniz, Ziya Haktan
    There are active and passive methods used to improve heat transfer. One of the passive methods is utilising porous media with high heat transfer surface area. Porous media are divided into two groups: regular and irregular structures. One of the regular structures is triply periodic minimal surfaces (TPMS), which have been studied quite frequently recently. In this study, heat transfer and flow analysis of a Gyroid geometry, one of the most used TPMS in the literature, is investigated numerically considering the conjugate heat transfer conditions. A single porosity is considered (epsilon = 0.6), and aluminium, ceramic and PLA are selected for the heat exchanger material to examine the temperature change in the heat exchanger. To understand the different flow characteristics, Reynolds numbers are assumed to be 19.12, 95.61 and 172.09. The fluid inlet temperature is assumed to be constant at 298.15 K, and the initial temperature of the heat exchanger is assumed to be constant at 278.15 K to be consistent with the regenerative heat recovery temperature difference in ventilation standards. Nusselt numbers under different operating conditions are compared, and it is the ceramic material with low thermal diffusivity is at the highest level despite its low thermal conductivity. At the highest Reynolds number, it provided approximately 6% better heat transfer than the aluminium heat exchanger.
  • Conference Object
    Citation - WoS: 5
    Citation - Scopus: 7
    Modeling Leakage of Ephemeral Secrets in Tripartite/Group Key Exchange
    (Institute of Electronics, Information and Communication, Engineers, IEICE, 2013) Manulis, Mark; Suzuki, Koutarou; Ustaoglu, Berkant
    We propose a security model, referred as g-eCK model, for group key exchange that captures essentially all non-trivial leakage of static and ephemeral secret keys of participants, i.e., group key exchange version of extended Canetti-Krawczyk (eCK) model. Moreover, we propose the first one-round tripartite key exchange (3KE) protocol secure in the g-eCK model under the gap Bilinear Diffie-Hellman (gap BDH) assumption and in the random oracle model.
  • Article
    Proliferative Effects and Cellular Uptake of Ceramic Nanoparticles in Cancer and Normal Cells
    (Univ Chemistry & Technology, Prague, 2024) Cesmeli, Selin; Tomak, Aysel; Winkler, David A.; Karakus, Ceyda Oksel
    The high biocompatibility, wear resistance, and high surface area-to-volume ratios of calcium phosphate (CaP) nanoparticles make them materials of great interest for a very broad range of medical applications, such as dentistry, drug delivery, biomedical imaging, gene transfection and silencing, biomedical imaging, immunisation, and bone substitution. While their use as an enamel remineralisation agent, a bone substitution material, an implant coating, and drug/gene delivery agents is widely approved by the regulating bodies, insufficient attention has been paid to the interactions of CaP-based nanoparticles with cells and organs once in the bloodstream and distributed through the body. Here, three different CaP-based nanoparticles (CP: calcium phosphate, TCP: tricalcium phosphate, and HAp: hydroxyapatite) were examined for the proliferative effects, oxidative damage potential, and cellular uptake in the human embryonic kidney (HEK293) and pancreatic cancer (Panc-1) cell lines. The physicochemical properties of the nanoparticles were characterised by Teller analysis, and X-ray diffraction spectroscopy. Maximum proliferative effects were generated by 400 mu g center dot ml-1 TCP (220 %) in HEK293 cells. Interestingly, although CP nanoparticles had the highest reactive oxygen species formation capacity in the HEK293 cells, they exhibited the lowest proliferative effects and a relatively low internalisation rate, suggesting a minimal correlation between the cellular uptake level and oxidative potential.
  • Article
    Citation - WoS: 5
    Citation - Scopus: 5
    Mechanical Behaviour of Photopolymer Cell-Size Graded Triply Periodic Minimal Surface Structures at Different Deformation Rates
    (Mdpi, 2024) Yilmaz, Yunus Emre; Novak, Nejc; Al-Ketan, Oraib; Erten, Hacer Irem; Yaman, Ulas; Mauko, Anja; Ren, Zoran
    This study investigates how varying cell size affects the mechanical behaviour of photopolymer Triply Periodic Minimal Surfaces (TPMS) under different deformation rates. Diamond, Gyroid, and Primitive TPMS structures with spatially graded cell sizes were tested. Quasi-static experiments measured boundary forces, representing material behaviour, inertia, and deformation mechanisms. Separate studies explored the base material's behaviour and its response to strain rate, revealing a strength increase with rising strain rate. Ten compression tests identified a critical strain rate of 0.7 s-1 for "Grey Pro" material, indicating a shift in failure susceptibility. X-ray tomography, camera recording, and image correlation techniques observed cell connectivity and non-uniform deformation in TPMS structures. Regions exceeding the critical rate fractured earlier. In Primitive structures, stiffness differences caused collapse after densification of smaller cells at lower rates. The study found increasing collapse initiation stress, plateau stress, densification strain, and specific energy absorption with higher deformation rates below the critical rate for all TPMS structures. However, cell-size graded Primitive structures showed a significant reduction in plateau and specific energy absorption at a 500 mm/min rate.
  • Article
    Citation - WoS: 4
    Citation - Scopus: 3
    Expression Patterns of M6a Rna Methylation Regulators Under Apoptotic Conditions in Various Human Cancer Cell Lines
    (TUBITAK, 2024) Alasar, Azime Akçaöz; Sağlam, Buket; Vatansever, İpek Erdoğan; Akgül, Bünyamin
    Background/aim: Cancer is a complex disease that involves both genetic and epigenetic factors. While emerging evidence clearly suggests that changes in epitranscriptomics play a crucial role in cancer pathogenesis, a comprehensive understanding of the writers, erasers, and readers of epitranscriptomic processes, particularly under apoptotic conditions remains lacking. The aim of this study was to uncover the changes in the expression of m6A RNA modifiers under apoptotic conditions across various cancer cell lines. Materials and methods: Initially, we quantified the abundance of m6A RNA modifiers in cervical (HeLa and ME180), breast (MCF7 and MDA-MB-231), lung (A549 and H1299), and colon (Caco-2 and HCT116) cancer cell lines using qPCR. Subsequently, we induced apoptosis using cisplatin and tumor necrosis factor-alpha (TNF-α) to activate intrinsic and extrinsic pathways, respectively, and assessed apoptosis rates via flow cytometry. Further, we examined the transcript abundance of m6A RNA modifiers under apoptotic conditions in cervical, breast, and lung cancer cell lines using qPCR. Results: Overall, treatment with cisplatin increased the abundance of m 6A modifiers, whereas TNF-α treatment decreased their expression in cervical, breast, and lung cancer cell lines. Specifically, cisplatin-induced apoptosis, but not TNF-α-mediated apoptosis, resulted in decreased abundance of METTL14 and FTO transcripts. Additionally, cisplatin treatment drastically reduced the abundance of IGF2BP2 and IGF2BP3 readers. Conclusion: These results suggest that the differential response of cancer cells to apoptotic inducers may be partially attributed to the expression of m6A RNA modifiers.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    Euler-Zagier Sums Via Trigonometric Series
    (Publishing House of the Romanian Academy, 2023) Çam Çelik, Şermin; Göral, Haydar
    In this note, we study the evaluations of Euler sums via trigonometric series. It is a commonly believed conjecture that for an even weight greater than seven, Euler sums cannot be evaluated in terms of the special values of the Riemann zeta function. For an even weight, we reduce the evaluations of Euler sums into the evaluations of double series and integrals of products of Clausen functions. We also re-evaluate Euler sums of odd weight using a new method based on trigonometric series.