WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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Department: search.filters.department.İzmir Institute of TechnologySubject: search.filters.subject.Design

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  • Article
    Citation - WoS: 9
    Citation - Scopus: 13
    Microservice-Based Projects in Agile World: a Structured Interview
    (Elsevier, 2024) Unlu, Huseyin; Kennouche, Dhia Eddine; Soylu, Gorkem Kiling; Demirors, Onur
    Context: During the last decade, Microservice-based software architecture (MSSA) has been a preferred design paradigm for a growing number of companies. MSSA, specifically in the form of reactive systems, has substantial differences from the more conventional design paradigms, such as object-oriented analysis and design. Therefore, adaptation demands software organizations to transform their culture. However, there is a lack of research studies that explore common practices utilized by software companies that implement MSSAs.Objective: In this study, our goal is to get an insight into how practices such as an agile methodology, software analysis, design, test, size measurement, and effort estimation are performed in software projects which embrace the Microservice-based software architecture paradigm. Together with the identification of practices utilized for the MSSA paradigm, we aim to determine the challenges organizations face to adopt microservice-based software architectures.Method: We performed a structured interview with participants coming from 20 different organizations over different roles, domains, and countries to collect information on their views, experience, and the challenges faced.Results: Our results reveal that organizations find agile development compatible with microservices. In general, they continue to use traditional object-oriented modeling notations for analysis and design in an abstract way. They continue to use the same subjective size measurement and effort estimation approaches that they were using previously in traditional architectures. However, they face unique challenges in developing microservices.Conclusion: Although organizations face challenges, practitioners continue to use familiar techniques that they have been using for traditional architectures. The results provide a snapshot of the software industry that utilizes microservices.
  • Article
    Citation - WoS: 3
    Citation - Scopus: 3
    Synthesis, Cytotoxicity, and Antibacterial Studies of 2,4,5,6-Substituted Hexahydro-1h
    (Wiley, 2023) Yetişkin, Egehan; Gündoğdu, Özlem; Mete, Derya; Celebioglu, Neslihan; Kara, Yunus; Şanlı-Mohamed, Gulsah
    In this study, synthesis of novel isoindole-1,3-dione analogues bearig halo, hydroxy, and acetoxy groups at the position 4,5,6 of the bicyclic imide ring was performed to examine their potential anticancer effects against some cell lines. A multistep chemical pathway was used to synthesize the derivatives. The cytotoxic effect of trisubstituted isoindole derivatives were evaluated by determining cellular viability using the MTT assay against A549, PC-3, HeLa, Caco-2, and MCF-7 cell lines. The C-2 selective ring-opening products were obtained from the ring-opening reaction of 5-alkyl/aryl-2-hydroxyhexahydro-4H-oxireno[2,3-e]isoindole-4,6(5H)-diones with nucleophiles such as chloride (Cl-) and bromide (Br-) ions. In addition, the ring-opening products halodiols were converted to their related acetates. The anticancer activity of synthesized isoindole-1,3-dione derivatives was investigated against HeLa, A549, MCF-7, PC3, and Caco-2 cells in vitro and resulted in varies cytotoxic effect depend on the group attached to the isoindole molecule. Furthermore, the evaluation of the antimicrobial action of trisubstituted isoindole derivatives against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria was assessed and found out selective inhibition of the both bacterial growth via different trisubstituted isoindole derivatives. The results of this work encourage further research on the potential utilization of trisubstituted isoindole derivatives as cytotoxic and antimicrobial agents.