WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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Department: search.filters.department.İzmir Institute of Technology. Chemical EngineeringPublisher: search.filters.publisher.John Wiley and Sons Inc.

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Now showing 1 - 10 of 48
  • Conference Object
    Antioxidant, Antimicrobial and Cytotoxic Activities of Some Turkish Plant Extracts
    (John Wiley and Sons Inc., 2006) Altıok, Evren; Asbagh, L. Abbasi; Bulut, Çisem; Ülkü, Semra; Bayraktar, Oğuz
    Plant extracts have been known to possess notable biological activity, including antioxidant, antimicrobial and cytotoxic properties. There is a growing interest in the use of natural products in the human food industries as consumer resistance to synthetic additives increases. These products can be used to improve human health. In vitro antioxidant, antimicrobial and cytotoxic activities of ethanol extracts of some plants from Urla region in Turkey were investigated. Plant materials were collected from Pistacia lentiscus, Vitex agnus-castus, Cistus creticus and Nerium oleander in October, November and December.
  • Conference Object
    Antimicrobial Activity of Essential Oils Against H. Pylori
    (John Wiley and Sons Inc., 2010) Altıok, Duygu; Bekmen, N.; Demiray Gürbüz, Ebru; Tıhmınlıoğlu, Funda; Yılmaz, Özlem
    [No abstract available]
  • Conference Object
    A Natural Antioxidant: Trans-Resveratrol Against H. Pylori
    (John Wiley and Sons Inc., 2010) Altıok, Duygu; Demiray Gürbüz, Ebru; Bekmen, N.; Tıhmınlıoğlu, Funda; Yılmaz, Özlem
    [No abstract available]
  • Conference Object
    Genipin Crosslinked Clarithromycin Loaded Chitosan Microspheres for Eradication of Helicobacter Pylori
    (John Wiley and Sons Inc., 2011) Altıok, Duygu; Demiray Gürbüz, Ebru; Bekmen, N.; Yılmaz, Özlem; Tıhmınlıoğlu, Funda
    [No abstract available]
  • Article
    Citation - WoS: 69
    Citation - Scopus: 77
    Novel Zein-Based Multilayer Wound Dressing Membranes With Controlled Release of Gentamicin
    (John Wiley and Sons Inc., 2019) Kimna, Ceren; Tamburacı, Sedef; Tıhmınlıoğlu, Funda
    Recently, functional multilayer scaffolds with controlled drug release ability come into prominence for wound healing applications to mimic the layered structure of skin tissue and prevent the possible infections at the defect site. In this study, controlled antibiotic releasing zein bilayer membranes were fabricated for treatment of acute skin infections. Gentamicin loaded fibers were prepared by electrospinning on the membrane surface. Membranes were characterized with scanning electron microscope, atomic force microscopy, Fourier transform infrared spectroscopy, contact angle, mechanical analysis, swelling, degradation, and water vapor permeability studies. In vitro cytotoxicity, cell attachment, and proliferation were investigated. Cell attachment on fiber layer was observed with fluorescence imaging. Fabricated fibers showed structural similarity to the skin tissue layers with a fiber diameter range of 350-425 nm and film thickness in the range of 311-361 mu m. Mechanical properties were found compatible with the skin tissue. In addition, membranes showed antimicrobial activity against Staphylococcus aureus and Escherichia coli. The sustained release was achieved with a cumulative release of 94%. Membranes did not show any cytotoxic effect. NIH/3T3 and HS2 cell lines were proliferated on each layer mimicking the multilayer skin tissue. Hence, zein-based bilayer membrane showed promising properties to be used as a potential antimicrobial wound dressing for skin tissue regeneration. (c) 2018 Wiley Periodicals, Inc.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    The Effect of Mass Transfer Resistance and Nonuniform Initial Solvent Concentration on Permeation Through Polymer Membranes
    (John Wiley and Sons Inc., 2018) Zielinski, John M.; Alsoy Altınkaya, Sacide
    A numerical simulation model has been developed which enables one to examine the effects of surface mass transfer resistance on the evaluation of permeation (P*), diffusion (D), and solubility (S) coefficients from unsteady-state mass transfer experiments as well as the transmission rate. A complementary analytical expression has been developed which validates the numerical model and facilitates the evaluation of the concentration dependence of P*, D, and S from sequential step-change experiments, under experimental conditions when the surface mass transfer resistance can be neglected.
  • Article
    Citation - WoS: 2
    Citation - Scopus: 10
    Water and Water Vapor Sorption Studies in Poly(propylene)-Zeolite Composites
    (John Wiley and Sons Inc., 2003) Pehlivan, Hilal; Özmıhçı, Filiz; Tıhmınlıoğlu, Funda; Balköse, Devrim; Ülkü, Semra
    Water and water vapor sorption to porous poly(propylene)zeolite composites prepared by hot pressing have been studied as a function of zeolite loading. This work presents the first report on the effect of the zeolite as a filler on the water sorption properties of PP composites. Water swelling experiments were conducted at 25°C using pure PP and PP-zeolite film samples having different zeolite loadings (6-40 wt%). Since PP is a hydrophobic polymer, it does not sorp any water, but the composites having 10, 20, 30, and 40% zeolite sorbed 0.63, 1.00, 1.72 and 3.74 wt% water, respectively. The zeolite itself at the same conditions sorbed 24.5 wt% water. As the filler loading in the composites increased, equilibrium uptake values increased too. On the other hand, water vapor sorption and kinetics has been studied using a Cahn 2000 gravimetric sorption system. Within in the range 0.35-0.95%, water vapor was adsorbed by the composites containing 10-40 wt% zeolite. Experimental effective water vapor diffusivities of the composite films were about one order of magnitude higher than the experimental water diffusion coefficient in composites. The transport of water in composites was slower than that in the liquid water due to the longer diffusion pathway and adsorption on the surface of the composites. Although the liquid water may fill all the voids in the composite, water vapor is adsorbed on the surface of the zeolite only.
  • Article
    Citation - WoS: 27
    Citation - Scopus: 37
    Nanofibrous Gelatine Scaffolds Integrated With Nerve Growth Factor-Loaded Alginate Microspheres for Brain Tissue Engineering
    (John Wiley and Sons Inc., 2018) Büyüköz, Melda; Erdal, Esra; Alsoy Altınkaya, Sacide
    Neural regeneration research is designed in part to develop strategies for therapy after nerve damage due to injury or disease. In this study, a new gelatine-based biomimetic scaffold was fabricated for brain tissue engineering applications. A technique combining thermally induced phase separation and porogen leaching was used to create interconnected macropores and nanofibrous structure. To promote tissue regeneration processes, the scaffolds were integrated with nerve growth factor (NGF)-loaded alginate microspheres. The results showed that nanofibrous matrix could only be obtained when gelatine concentration was at least 7.5% (w/v). The scaffold with a modulus value (1.2 kPa) similar to that of brain tissue (0.5–1 kPa) was obtained by optimizing the heat treatment time, macropore size and gelatine concentration. The encapsulation efficiencies of NGF into 0.1% and 1% alginate microspheres were 85% and 100%, respectively. The release rate of NGF from the microspheres was controlled by the alginate concentration and the poly(L-lysine) coating. The immobilization of the microspheres in the scaffold reduced burst release and significantly extended the release period. The nanofibrous architecture and controlled release of NGF from the microspheres induced neurite extension of PC12 cells, demonstrating that the released NGF was in an active form. The results suggest that the scaffolds prepared in this study may have potential applications in brain tissue engineering due to topologic and mechanical properties similar to brain tissue and pore structure suitable for cell growth and differentiation.
  • Article
    Citation - WoS: 8
    Citation - Scopus: 8
    Phase Equilibrium and Diffusion of Solvents in Polybutadiene: a Capillary-Column Inverse Gas Chromatography Study
    (John Wiley and Sons Inc., 2002) Cai, W. D.; Ramesh, N.; Tıhmınlıoğlu, Funda; Danner, Ronald P.; Duda, John Larry; De Haan, A.
    The capillary-column inverse gas chromatography method was used to measure the diffusion and partition coefficients of ethylbenzene, styrene, and acrylonitrile in polybutadiene (PBD) at infinite dilution of the solvents. Experiments were performed over a temperature range of 50-125°C. At temperatures well above the glass-transition temperature of PBD, the diffusivities were correlated using an Arrhenius expression. The Arrhenius parameters in turn were intercorrelated and shown to be a function of the occupied volume, thus providing a method for predicting the diffusion of other solvents in the same polymer. Further, the activation energy was predicted using the Duda-Vrentas free-volume approach. The activation energy thus obtained was compared with the activation energy of the Arrhenius approach. The weight-fraction activity coefficient data were compared to the predictions of the group contribution, lattice-fluid equation-of-state, and the UNIquac Functional-group Activity Coefficient (UNIFAC) free-volume models.
  • Article
    Effects of Reactor Pressure and Inlet Temperature on N-butane/Dimethyl Ether Oxidation and the Formation Pathways of the Aromatic Species
    (John Wiley and Sons Inc., 2016) Bekat, Tuğçe; İnal, Fikret
    Oxidation of n-butane/dimethyl ether (DME)/O2/Ar system was studied by chemical kinetic modeling in a tubular reactor operated adiabatically and at constant pressure. Effects of the reactor pressure on the formation of various major, minor, and trace oxidation products were investigated for two different pressures (1 and 5 atm) and at six different inlet temperature values (700, 800, 900, 1100, 1300, and 1500 K). The analysis was carried out for two different concentrations of dimethyl ether in the inlet fuel mixture (20 and 50 mol %). Higher pressure (5 atm) resulted in higher mole fractions of methane, vinylacetylene, and cyclopentadiene; and lower mole fractions of formaldehyde, acetylene, acetaldehyde, ethane, propargyl, and propane. The mole fractions of CO and CO2 were not affected considerably by the pressure change. The main formation routes of benzene were developed at two different inlet temperature values (1100 and 1300 K), and the main precursors participating in these routes were found to be propargyl, propene, and diacetylene. A skeletal mechanism was developed for the oxidation of n-butane/DME mixture from the detailed mechanism by reduction of the elementary reactions by 79%, and it was tested for accuracy by comparison with the data from the literature.