WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Conference Object Investigation of Antimicrobial Activity To Determine Mic Value of Cinnamon Bark Oil Against Helicobacter Pylori(Wiley, 2014) Güneş, Seda; Becerikli, T.; Tıhmınlıoğlu, Funda; Yılmaz, Özlem[No abstract available]Conference Object In Vitro Evaluation of Bioactive Chitosan Microspheres for Eradicating Helicobacter Pylori Biofilm(Wiley, 2016) Güneş, Seda; Arslan, Nur; Demiray Gürbüz, Ebru; Tıhmınlıoğlu, Funda; Yılmaz, ÖzlemCertain H. pylori strains can form biofilm both inside and outside human host to protect itself under environmental stress. Biofilm contributes to development of antimicrobial resistance by some kind of mechanisms like providing a barrier for diffusion and allowing resistance gene expression.Conference Object Determination of Biofilm Formation by Helicobacter Pylori(Wiley, 2016) Arslan, Nur; Güneş, Seda; Demiray Gürbüz, Ebru; Tıhmınlıoğlu, Funda; Yılmaz, ÖzlemBackground : Certain H. pylori strains form biofilm in laboratory experiments and also on the surface of gastric mucosa, suggesting possible reason for eradication failure by increasing resistance to antimicrobial agents and transmission. Aim : To examine the mature biofilm formation by H. pylori NCTC11637 standard strain in different incubation periods for H. pylori biofilm characterization.Article Citation - WoS: 32Citation - Scopus: 36A Novel Bilayer Zein/Mmt Nanocomposite Incorporated With H. Perforatum Oil for Wound Healing(Springer, 2020) Güneş, Seda; Tamburacı, Sedef; Tıhmınlıoğlu, FundaRecently, layered structures composed of nanofibers have gained attention as a novel material to mimic skin tissue in wound healing applications. The aim of this study is to develop a novel hybrid bilayer material composed of zein based composite film and nanofiber layers as a wound dressing material. The upper layer was composed of H. perforatum oil incorporated zein film including MMT and the bottom layer was comprised of 3D electrospun zein/MMT nanofibers to induce wound healing with the controlled release of H. perforatum oil. The bilayer composites were characterized in terms of mechanical test, WVP, water uptake and surface wettability. Antimicrobial activity of the wound dressings against microorganisms were investigated by disc diffusion method. In vitro cytotoxicity of monolayer film and bilayer structure was performed using WST-1 assay on HS2 keratinocyte and 3T3 cell lines. Results indicated that the prepared monolayer films showed appropriate mechanical and gas barrier properties and surface wettability for wound healing. Controlled release of H. perforatum oil was obtained from fabricated membranes up to 48 h. Bilayer membranes showed antimicrobial activity against E. coli, S. aureus, and C. albicans and did not show any toxic effect on NIH3T3 mouse fibroblast and HS2 keratinocyte cell lines. In vitro scratch assay results indicated that H. perforatum oil had a wound healing effect by inducing fibroblast migration. The proliferation study supported these results by increasing fibroblast proliferation on H. perforatum oil loaded bilayer membranes.Article Citation - WoS: 96Citation - Scopus: 113Hypericum Perforatum Incorporated Chitosan Films as Potential Bioactive Wound Dressing Material(Elsevier Ltd., 2017) Güneş, Seda; Tıhmınlıoğlu, FundaRecent studies in wound dressing applications offer new therapies and promote wound healing process. The aim of this study was to develop Hypericum perforatum (St John's Wort) oil incorporated chitosan films for wound dressing applications. H. perforatum oil as a potential therapeutic agent was encapsulated in chitosan film to achieve a better wound dressing material. Oil incorporated chitosan films were successfully prepared by solvent casting method in different oil concentrations (0.25–1.5%v/v). Water vapor permeability (WVP), mechanical test, swelling behavior and surface hydrophobicity were performed in order to characterize the prepared films. Antimicrobial test was performed by disc diffusion method and the growth inhibition effects of the films including different amount of H. perforatum oil were investigated on Escherichia coli and Staphylococcus aureus. WVP increased with oil incorporation and the highest value was obtained for 0.25% oil concentration.The highest strain value was obtained in 0.25% oil content films although tensile stress decreased with increasing oil content. H. perforatum oil incorporated films had antimicrobial effect on both microorganisms. Chitosan based films had no cytotoxic effects on NIH3T3fibroblast cells and provided a good surface for cell attachment and proliferation. The results showed that the H. perforatum incorporated chitosan films seems to be a potential and novel biomaterial for wound healing applications.