WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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  • Conference Object
    Citation - WoS: 28
    Strongly Secure Authenticated Key Exchange Without Naxos' Approach
    (Springer Verlag, 2009) Kim, Minkyu; Fujioka, Atsushi; Ustaoğlu, Berkant
    LaMacchia, Lauter and Mityagin [15] proposed the extended Canetti-Krawczyk (eCK) model and an AKE protocol, called NAXOS. Unlike previous security models, the adversary in the eCK model is allowed to obtain ephemeral secret information related to the test session, which makes the security proof difficult. To overcome this NAXOS combines an ephemeral private key x with a static private key a to generate an ephemeral public key X; more precisely X∈=∈g H(x,a). As a result, no one is able to query the discrete logarithm of X without knowing both the ephemeral and static private keys. In other words, the discrete logarithm of an ephemeral public key, which is typically the ephemeral secret, is hidden via an additional random oracle. In this paper, we show that it is possible to construct eCK-secure protocol without the NAXOS' approach by proposing two eCK-secure protocols. One is secure under the GDH assumption and the other under the CDH assumption; their efficiency and security assurances are comparable to the well-known HMQV [12] protocol. Furthermore, they are at least as secure as protocols that use the NAXOS' approach but unlike them and HMQV, the use of the random oracle is minimized and restricted to the key derivation function. © 2009 Springer-Verlag Berlin Heidelberg.
  • Article
    Citation - WoS: 42
    Citation - Scopus: 48
    The Roles of Bioactive Sphingolipids in Resveratrol-Induced Apoptosis in Hl60 Acute Myeloid Leukemia Cells
    (Springer Verlag, 2011) Çakır, Zeynep; Saydam, Güray; Şahin, Fahri; Baran, Yusuf
    Purpose Acute promyelocytic leukemia results from a translocation between 15 and 17 chromosomes that produce PML/RARa fusion protein. PML/RARa inhibits differentiation of myeloid precursor cells at stem cell level. Resveratrol is a phytoalexin that exerts cytotoxic effects on cancer cells. Ceramides have crucial roles in cell growth, proliferation, differentiation, drug resistance, and apoptosis. In this study, we examined the possible cytotoxic effects of resveratrol on acute myeloid leukemia cells and determined the roles of ceramide-metabolizing genes in resveratrol-induced apoptosis, in addition to investigating the possibility of increasing the sensitivity of HL60 cells to resveratrol by manipulating sphingolipids. Methods Cytotoxic effects of resveratrol, C8:ceramide, PDMP, and SK-1 inhibitor were determined by XTT cell proliferation assay. Changes in caspase-3 enzyme activity and mitochondrial membrane potential (MMP) were measured using caspase-3 colorimetric assay and JC-1 MMP detection kit. Expression levels of ceramide-metabolizing genes were examined by RT-PCR. Results The results revealed that manipulations of ceramide metabolism toward generation or accumulation of apoptotic ceramides increased apoptotic effects of resveratrol in HL60 cells, synergistically. More importantly, gene expression analyses revealed that resveratrol-induced apoptosis via increasing expression levels of ceramide generating genes and decreasing expression levels of antiapoptotic sphingosine kinase-1 and glucosylceramide synthase genes. Conclusion These results showed for the first time that increasing intracellular levels of ceramides by biochemical approaches has also increased sensitivity of HL60 cells to resveratrol. We also showed that resveratrol induces apoptosis through manipulating ceramide-metabolizing genes that resulted in the accumulation of ceramides in HL60 cells.