WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article Influence of Innovative Thawing Approaches on the Thermal and Chemical Structure Changes of Frozen Beef Liver(Springer, 2026) Avsar, Nazlican; Uzuner, SibelFreezing effectively preserves meat quality, but the formation of ice crystals during the process can impact tenderness and functionality. Thawing is a critical step, as it can lead to physicochemical changes-such as protein oxidation and further ice crystal growth-that may reduce product quality and consumer appeal. Therefore, the thawing method plays a key role in determining the final quality of frozen meat. This study evaluated the physicochemical and structural characteristics of beef liver frozen at - 18 +/- 2 degrees C for 20 h and thawed using three methods: water immersion thawing (WIT), ultrasonic bath thawing (UBT), and air fryer thawing (AFT). No significant differences in drip loss were observed among the UBT, AFT, and WIT samples (p > 0.05). Color measurements (L*, a*, b*) were significantly higher in raw liver than in AFT and UBT samples (p < 0.05). Compared to raw liver and the WIT method, AF and UB thawing lowered the denaturation temperature, indicating reduced thermal stability. The lowest metmyoglobin (MetMb) content was found in the UBT sample (36.57 +/- 0.87%), followed by the AFT sample (41.71 +/- 1.29%), suggesting better pigment preservation with UB thawing. Highlights circle AF and UB thawing methods resulted in a lower denaturation temperature. circle UBT showed the lowest MetMb content, helping to minimize oxidation. circle UBT caused less damage to protein chains and better preserved structural stability. circle UBT preserved desirable aroma characteristics more effectively.Article Anticancer Properties of Newly Synthesized Pyrrole Derivatives as Potential Tyrosine Kinase Inhibitors(Wiley, 2026) Kaya, Meltem; Kara, Yunus; Sanli-Mohamed, GulsahThe anticancer activity of a series of newly synthesized pyrrole derivatives was systematically evaluated in HeLa cervical cancer cells, focusing on their potential as tyrosine kinase inhibitors and modulators of the mTOR signaling pathway. This study builds on our previous synthetic work by investigating the biological effects of seven structurally characterized compounds (d1-d7). Among them, compounds d1 and d3 exhibited the most potent cytotoxicity, with IC50 values of 140.6 mu M and 366.4 mu M, respectively, after 48 h of treatment. Both compounds significantly impaired cell cycle progression-d1 induced S-phase arrest, while d3 caused G1-phase arrest-and markedly suppressed cell migration in wound healing assays. Mechanistically, these effects were accompanied by reduced phosphorylation of p70S6K (Thr389, Ser421/424) and increased p-4EBP1, indicating inhibition of mTORC1 signaling. These findings suggest that d1 and d3 are promising lead compounds with dual antiproliferative and anti-migratory activity in cervical cancer, mediated through modulation of the PI3K/Akt/mTOR axis.Article Application of 3D Cell Culture Techniques in Nanotoxicology: How Far Are We(Springer, 2026) Shakeri, Raheleh; Mirjalili, Seyedeh Zohreh; Karakus, Ceyda Oksel; Safavi, MalihehInvestigation of toxicological profile and possible side effects of engineered nanomaterials (ENMs) is of high importance. Historically, two-dimensional (2D) cell culture was used to study the toxicity of the ENMs, but due to their inability to simulate in vivo cell behavior, three-dimensional (3D) cell culture systems have been developed. Nanotoxicity studies initiate with in vitro experiments and continue with in vivo studies, which are very challenging and sometimes accompanied by conflicting data due to the in vitro-in vivo gap. Thus, scientists are turning their attention to microfabrication techniques and engineered systems "called organ-on-a-chips", which act as an intermediate between in vivo and in vitro systems. The present account tries to review the classical study models and suitably cover the emerging 3D culture models including scaffold-free and scaffold-based 3D cell cultures, 3D co-culture with direct contact and without cell-cell contact methods as well as microfluidic-based tissue chips and organoids. Overall, this review aims to give readers a better insight about the ENMs' toxicology and fill the gaps between the knowledge and practical techniques. Hopefully, the presented information will resolve the issues of 2D in vitro cultures and display the clinically relevant responses to the concerns of therapeutic ENMs.Article Liposomal Encapsulation of a Synthetic Bromophenol for Antitumor Efficacy and Apoptotic Activity in Cancer Cells(Springer, 2026) Oztanrikulu, Bercem Dilan; Ozdemir, Ekrem; Avci, Bahri; Goksu, Suleyman; Bayrakceken, Handan Uguz; Askin, HakanA novel synthetic bromophenol (BP), inspired by marine-derived natural bromophenols, was evaluated for its antitumor activity and for the enhancement of its in vitro performance through liposomal encapsulation (LipoBP). Etoposide was used as a reference in characterization, release, and loading studies. PEGylated liposomes were employed to improve BP's solubility, bioavailability, and therapeutic potential. The cytotoxicity, apoptosis, and gene expression effects of free BP and LipoBP were assessed in A549 (lung) and MCF-7 (breast) cancer cell lines. WST-8 assays showed that encapsulation significantly increased BP's cytotoxic activity, particularly in A549 cells, while flow cytometry and Annexin V-FITC/PI analyses indicated more pronounced apoptotic induction by LipoBP compared with free BP. qRT-PCR analyses revealed upregulation of proapoptotic genes (BAX, CASP6, CASP3 and CASP9) and downregulation of antiapoptotic/survival genes (BCL-XL, IQSEC2) in both cell lines, indicating activation of intrinsic apoptotic pathways. Plain liposomes exhibited minimal cytotoxicity, confirming their biocompatibility. Liposomal bromophenol, which we have introduced to the literature for the first time, is expected to be a promising nanocarrier system that could be effective in cancer treatment by improving the therapeutic index of new drug candidates such as marine bromophenols.Article A Phenomenological Kinetic Flotation Model: Intrinsic Floatability Profiling for Batch and Continuous Flotation Systems(Springer Heidelberg, 2026) Polat, Mehmet; Guzel, Veli; Kobas, Muammer; Polat, HurriyetThis study presents a mechanistic flotation kinetics model that unifies the description of mineral particle floatability in both batch and continuous systems. Building on a physically explicit interpretation of bubble-particle interactions, the model introduces the concept of intrinsic floatability, \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\upphi }_{\text{P},\text{ij}}<^>{\text{s}}$$\end{document}, defined as the size-and composition-dependent probability that a particle within a bubble's sweep volume reports to the froth. A central feature of the framework is that \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\upphi }_{\text{P},\text{ij}}<^>{\text{s}}$$\end{document} is decoupled from system-level rate-determining factors, such as bubble-particle encounter frequency, transport limits, and bubble surface crowding-that otherwise confound attempts to extract floatability distributions from kinetic data. This separation is achieved through three explicit, time-dependent parameters: the encounter rate kappa(t), the limiting flotation rate mu(t), and the bubble saturation factor chi(t). Together, these parameters isolate intrinsic particle behavior from external constraints. The model naturally reduces to the classical first-order rate law in dilute pulps, while in concentrated suspensions it predicts systematic deviations, approaching zero-order kinetics as bubble surfaces saturate. Importantly, the same formulation applies seamlessly to batch tests and multi-stage continuous circuits, enabling a consistent theoretical framework across scales and ore types. Requiring only standard flotation data and known system parameters, the model is practical for both laboratory coal flotation studies and industrial non-coal applications. Validation using batch coal data and continuous plant-scale copper flotation results demonstrates its robustness and broad relevance.Article Robust Scheduling of Crude Oil Farming and Processing Under Uncertainty(Elsevier, 2026) Yalcin, Damla; Sildir, HasanThe sulphur content in crude oil has a significant impact on refinery operations, influencing the feasibility of crude blending, the distribution of product yields, and overall economic performance. Variations in sulphur content introduce uncertainty in the short-term scheduling of crude oil loading, blending, and distillation processes. This study introduces a scenario-based stochastic optimization framework in which sulphur uncertainty is treated as a central modeling element, represented through a regression-based relationship with specific gravity (SG). The approach systematically propagates uncertainty through blending decisions, crude distillation unit (CDU) feed composition, and product yields. The problem is modeled as a mixed-integer quadratically constrained programming (MIQCP) formulation within a continuous-time scheduling framework, enabling the simultaneous optimization of timing, blending, and processing strategies. The results indicate that increased sulphur uncertainty adversely affects the distribution of yields for nine end-products, resulting in profit losses. These findings underscore the importance of explicitly managing compositional uncertainty and provide insights into cost-performance trade-offs in refinery scheduling.Article Rice-Like, Hollow, and Rhombohedral Nano-Calcite Synthesis by Carbonization(Elsevier, 2026) Kilic, Sevgi; Toprak, Gorkem; Ozdemir, EkremControlling the morphology and size of calcium carbonate (CaCO3) remains an essential challenge in the production of high-performance fillers and advanced functional materials. Here, we report a continuous carbonization strategy that enables the synthesis of monodisperse nano-calcite particles with tunable rice-like, hollow, and rhombohedral morphologies through precise control of CO2 dissolution into a flowing Ca(OH)2 solution under diffusion-limited conditions. A two-stage reactor was designed to decouple nucleation and growth by separating the gas-liquid interaction zone from a stabilization tank. pH and conductivity analyses revealed that crystallization is primarily governed by the CO2 dissolution kinetics rather than mixing intensity in the stabilization tank. SEM and XRD analyses demonstrate a distinct crystallization sequence such that initial formation of rice-like calcite, subsequent development of hollow nanoparticles through selective tip dissolution, and final transformation into rhombohedral calcite via dissolution-reprecipitation mechanism. The method provides a reproducible, template-free route for fabricating hollow CaCO3 nanoparticles, overcoming limitations of bubbletemplating and additive-mediated techniques. This scalable process provides a robust foundation for producing high-surface-area CaCO3 nanomaterials which have potential applications in thin films, ceramics, protective coatings, lightweight composites, thermal/acoustic insulation, adsorption, and catalysis, where tailored particle morphology and size can significantly enhance performance.Article Fluid-CO2 Injection in a Hypersaline Volcanic Systems: A Reactive Transport and Experimental Evaluation with Application to the Tuzla Geothermal Field, Turkiye(Springer, 2026) Tonkul, Serhat; Erol, Selcuk; Baba, Alper; Regenspurg, SimonaThis study evaluates the CO2 sequestration capability of the Tuzla Geothermal Field (TGF) in northwest T & uuml;rkiye under reservoir conditions (200 degrees C and 4.4 MPa). While ongoing studies at TGF have investigated CO2 co-injection primarily for geothermal heat extraction, the present study focuses on the associated potential for long-term CO2 storage. To this end, CO2-brine-rock interactions were examined through batch reactor experiments and reaction path modeling using the PhreeqC geochemical tool. The experiments revealed complex dissolution/precipitation reactions that altered reservoir properties, with mineralogical analyses (XRD, XRF, SEM, and EDS) showing the formation of secondary phases such as calcite, kaolinite, and Ca-rich aluminosilicates. These results indicate that the Tuzla reservoir rocks provide sufficient divalent cations to support mineral trapping under reservoir conditions. Overall, our findings highlight that, in addition to its promise for heat extraction, CO2 co-injection at TGF offers an opportunity for permanent geological storage, thereby strengthening the dual benefits of this approach.Article Mn2+ Removal From Water Using a Strong Acidic Shallow Shell Resin: Performance and Response Surface Optimization(Springer, 2026) Gucur, G.; Recepoglu, Y. K.; Ozcan, D. O.; Arar, O.The removal of manganese ions (Mn2+) from aqueous solutions using a strong acid cation-exchange resin, Purolite SST60, was investigated in the present study. The influences of resin dosage, temperature, and pH on Mn2(+) removal were optimized using Response Surface Methodology based on a Central Composite Design. Results showed that removal efficiency was highly pH-dependent, increasing from 63% at pH 1.0 to over 99% at pH 3.0 and above. Even with only 0.01 g of resin, 98% removal was achieved, indicating high performance at low dosages. Equilibrium data aligned with the Langmuir isotherm, indicating monolayer sorption with a maximum capacity of 91.06 mg/g. Kinetic data followed a pseudo-second-order model. Thermodynamic analysis confirmed a spontaneous and exothermic process, supported by a negative enthalpy change and positive entropy change, likely due to dehydration of Mn2+ ions upon binding. Competitive ion studies revealed that divalent ions, particularly calcium and magnesium, significantly hinder Mn2+ removal, whereas monovalent ions had minimal impact. Complete desorption of Mn2+ was achieved using hydrochloric or nitric acid at concentrations of 0.5 mol/L and above, confirming the resin's reusability. Overall, Purolite SST60 offers an efficient, regenerable, and robust solution for manganese removal in water treatment applications.Article A Physics-Informed Neural Network (PINN) Approach to Over-Equilibrium Dynamics in Conservatively Perturbed Linear Equilibrium Systems(MDPI, 2025) Dutta, Abhishek; Mukherjee, Bitan; Hosen, Sk Aftab; Turan, Meltem; Constales, Denis; Yablonsky, GregoryConservatively perturbed equilibrium (CPE) experiments yield transient concentration extrema that surpass steady-state equilibrium values. A physics-informed neural network (PINN) framework is introduced to simulate these over-equilibrium dynamics in linear chemical reaction networks without reliance on extensive time-series data. The PINN incorporates the reaction kinetics, stoichiometric invariants, and equilibrium constraints directly into its loss function, ensuring that the learned solution strictly satisfies physical conservation laws. Applied to three- and four-species reversible mechanisms (both acyclic and cyclic), the PINN surrogate matches conventional ODE integration results, reproducing the characteristic early concentration extrema (maxima or minima) in unperturbed species and the subsequent relaxation to equilibrium. It captures the timing and magnitude of these extrema with high accuracy while inherently preserving total mass. Through the physics-informed approach, the model achieves accurate results with minimal data and a compact network architecture, highlighting its parameter efficiency.