WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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Now showing 1 - 10 of 372
  • Article
    Gamma Secretase Inhibitors, DAPT and MK0752, Exhibit Synergistic Anticancer Effects with Cisplatin and Docetaxel in 2D and 3D Models of Breast Cancer
    (TÜBİTAK Scientific & Technological Research Council of Turkey, 2025) Telli, Kubra; Gubat, Johannes; D'Arcy, Padraig; Ozuysal, Ozden Yalcin
    Background/aim: Breast cancer remains a major malignancy among women, and severe side effects and the development of acquired drug resistance frequently hinder current therapeutic strategies. The Notch signaling pathway, a key regulator of cell fate, is commonly dysregulated in breast cancer and associated with poor prognosis. Gamma-secretase inhibitors (GSIs) block Notch receptor activation and have shown potential anticancer efficacy. This study aimed to investigate the synergistic activity of two commonly used GSIs, DAPT and MK0752, combined with docetaxel or cisplatin in both 2D and 3D breast cancer models. Materials and methods: Triple-negative, highly metastatic MDA-MB-231 and ER+/PR+ MCF-7 breast cancer cell lines were treated with DAPT or MK0752 alone or in combination with docetaxel or cisplatin. Drug efficacy and potential synergism were evaluated in 2D monolayer cultures and 3D spheroid models. Sequential treatment strategies were also assessed, where docetaxel or cisplatin was administered prior to GSI exposure. Results: Both MDA-MB-231 and MCF-7 cell lines exhibited notable sensitivity to DAPT and MK0752 combinations with docetaxel or cisplatin in 2D and 3D cultures. Synergistic enhancement of cytotoxicity was observed, particularly in sequential treatment regimens. Pretreatment with docetaxel or cisplatin followed by GSI exposure demonstrated superior growth inhibition compared with either monotherapy or simultaneous combination treatments. Conclusion: This study highlights the therapeutic potential of combining GSIs with standard chemotherapeutics to overcome drug resistance in breast cancer. The observed synergy and sequencing effects provide a strong basis for further mechanistic and translational investigations to optimize GSI-based combinational therapy strategies.
  • Article
    Brewing Property in Onedimensional City? Exploring Starbucks' Locational Strategies-Impacts in the Case of Izmir, Türkiye
    (University Cueca, 2026) Coskun, Yagmur Asci; Penpencioglu, Mehmet
    The article examines Starbucks'locational strategies and their impact on urban spaces, drawing on Rossi's concept of the "one-dimensional city." As global brands increasingly shape urban environments, three key effects emerge: rising property prices near stores, the concentration of locations in malls, transit hubs, and walkable areas, and alignment with urban landscapes standardized by major transportation infrastructure decisions. Similar to many cities in the Global South, Starbucks in & Idot;zmir functions both as a product and a driver of property-driven, rent-seeking urban development.Empirical evidence reveals that its locational strategies enhance accessibility, increase property values, and reshape the built environment. Through spatial analysis, the article examines Starbucks locations within a walkability and accessibility framework, highlighting their concentration in high-value districts with strong public transit connections.This research underscores how global brands reinforce socio-economic divides, transform urban spaces, and promote consumption-driven urbanization through their integration into global capitalism and real estate dynamics.
  • Article
    The Relation of Geogenic and Antrophogenic Factors with Blood and Hair Lead and Arsenic Levels in Women Living in Can and Bayramic Districts of Canakkale Province
    (Nobel Ilac, 2019) Baba, Alper; Gunduz, Orhan; Bakar, Coskun; Sulun, Serdar; Save, Dilsad
    Objective: Mining areas and associated industrial activities carry considerable risks for human health due to multi-pathway exposure of heavy metals such as arsenic and lead. The objective of this study was to compare arsenic and lead levels it human blood and hair samples in all industrial mining area in northwestern Turkey with that of non-exposed group demonstrating similar sociocultural characteristics. Material and Method: The population of the study consisted of 674 nonsmoker women over the age of 40 who were selected on random basis from mine region and control area. Venous blood samples were taken and analyzed fur blood lead and arsenic levels in all participants. Hair samples were later collected from 108 women with high levels in blood samples. Results: The results showed that the highest prevalence of occurrences was found in district centers whereas relatively lower values were observed in the villages. Hail arsenic and lead levels were comparably higher in the industrialized area (can Region) where low-quality coal combustion used in power generation and residential heating were dominant. Conclusion: Although high correlations were not found, blood and hair arsenic and lead levels in individuals living in industrial in agricultural areas were found to he high at levels influencing the human health On the other hand, these results should be further supported and verified with advanced and long duration monitoring activities.
  • Article
    Mock Alexander Polynomials
    (Australian National University, 2025) Gügümcü, Neslihan; Kauffman, L.H.
    In this paper, we construct Mock Alexander polynomials for starred links and linkoids in surfaces. These polynomials are defined as state summations on link or linkoid diagrams that satisfy f = n, where f denotes the number of regions and n denotes the number of crossings of diagrams. These new invariants are chirality and reversibility sensitive. © The authors.
  • Conference Object
    Citation - Scopus: 1
    Binet–Fibonacci Calculus and N = 2 Supersymmetric Golden Quantum Oscillator
    (Springer International Publishing AG, 2025) Pashaev, Oktay K.
    The Binet-Fibonacci calculus, as phi phi'-two base quantum calculus, relates Fibonacci derivative with Binet formula of Fibonacci number operator, acting in Fock space of quantum states. It provides a tool to study the Golden oscillator with energy spectrum in form of Fibonacci numbers. Here we generalize this model to supersymmetric number operator and corresponding Binet formula for supersymmetric Fibonacci operator F-N. It determines the Hamiltonian of supersymmetric Golden oscillator, acting in. H-f circle times H-b-fermion-boson Hilbert space and belonging to N = 2 supersymmetric algebra. Trace on fermions of this model reduces the Hamiltonian to the Golden oscillator. The eigenstates of the super Fibonacci number operator are double degenerate and can be characterized by a point of the super-Bloch sphere. By the supersymmetric Fibonacci annihilation operator, we construct the coherent states as eigenstates of this operator. Entanglement of fermions with bosons in these states is calculated by the concurrence, represented by the Gram determinant and Fibonacci exponential functions. These functions have been appeared as descriptive for inner product of the Golden coherent states in Fock-Bargmann representation. The reference state, coming from the limit alpha -> 0 and corresponding von Neumann entropy, measuring fermion-boson entanglement, are characterized by the Golden ratio.
  • Conference Object
    Geometry and Entanglement of Super-Qubit Quantum States
    (Springer International Publishing AG, 2025) Pashaev, Oktay K.; Kocak, Aygul
    We introduce the super-qubit quantum state, determined by superposition of the zero and the one super-particle states, which can be represented by points on the super-Bloch sphere. In contrast to the one qubit case, the one super-particle state is characterized by points in extended complex plane, equivalent to another super-Bloch sphere. Then, geometrically, the super-qubit quantum state is represented by two unit spheres, or the direct product of two Bloch spheres. By using the displacement operator, acting on the super-qubit state as the reference state, we construct the super-coherent states, becoming eigenstates of the super-annihilation operator, and characterized by three complex numbers. The states are fermion-boson entangled, and the concurrence of states is the product of two concurrences, corresponding to two Bloch spheres. We show geometrical meaning of concurrence as distance from point-state on the sphere to vertical axes. Then, probabilities of collapse to the north pole state and to the south pole state are equal to half-distances from vertical coordinate of the state to corresponding points at the poles. For complimentary fermion number operator, we get the flipped super-qubit state and corresponding super-coherent state, as eigenstate of transposed super-annihilation operator. The infinite set of Fibonacci oscillating circles in complex plane, describing quantum states with uncertainty relations as the ratio of two Fibonacci numbers, and in the limit at infinity becoming the Golden Ration uncertainty, is derived.
  • Conference Object
    Velocity-Level Kinematics of a Continuously Variable Transmission System for Phri
    (Springer International Publishing AG, 2025) Mobedi, Emir; Dede, Mehmet Ismet Can
    New generation robots pave the way for physical human-robot interaction (pHRI) through improvements in control and design techniques. While the former is achieved with the help of a number of sensory information, variable stiffness actuators (VSA) are exploited for the design of these robots to achieve inherent compliance. Recently, continuously variable transmission-based VSA has been developed to be used for pHRI, specifically for haptics. The fundamental characteristic of this new CVT mechanism is that it regulates output position and torque independently via the sphere transmission element. In this study, velocity-level kinematics of this new CVT system is carried out to demonstrate its step-less speed variation feature. Moreover, simulations are conducted in ADAMS and Solidworks software packages at 8 transmission points selected unequally. Results show that the average value of overall ADAMS and Solidworks errors computed with respect to the computed velocity are reported as 1.09%, and 0.53%, respectively.
  • Article
    Quantum Calculus of Fibonacci Divisors and Fermion-Boson Entanglement for Infinite Hierarchy of N=2 Supersymmetric Golden Oscillators
    (Pleiades Publishing Ltd, 2025) Pashaev, O. K.
    The quantum calculus with two bases, represented by powers of the golden and silver ratios, relates the Fibonacci divisor derivative with Binet formula for the Fibonacci divisor number operator, acting in the Fock space of quantum states. It provides a tool to study the hierarchy of golden oscillators with energy spectrum in the form of Fibonacci divisor numbers. We generalize this model to the supersymmetric number operator and corresponding Binet formula for the supersymmetric Fibonacci divisor number operator. The operator determines Hamiltonian of the hierarchy of supersymmetric golden oscillators, acting in fermion-boson Hilbert space and belonging to N = 2 supersymmetric algebra. The eigenstates of the super Fibonacci divisor number operator are double degenerate and can be characterized by a point on the super-Bloch sphere. By introducing the supersymmetric Fibonacci divisor annihilation operator, we construct the hierarchy of supersymmetric coherent states as eigenstates of this operator. The entanglement of fermions with bosons in these states is calculated by the concurrence, represented as the Gram determinant and expressed in terms of the hierarchy of golden exponential functions. We show that the reference states and the corresponding von Neumann entropy measuring the fermion-boson entanglement are characterized completely by powers of the golden ratio. We give a geometrical classification of entangled states by the Frobenius ball and interpret the concurrence as the double area of a parallelogram in a Hilbert space.
  • Article
    The Temperature Dependence of Elastic Constants and Zener Anisotropy in Single Crystal KTaO3 Below Room Temperature
    (Pleiades Publishing Ltd, 2025) Li, C. H.; Ding, X. D.; Carpenter, M. A.; Aktas, O.
    We present the first experimental report of the complete elastic tensor of incipient ferroelectric KTaO3 between 9.6 and 307 K, using resonant ultrasound spectroscopy (RUS). The elastic constants C-11 and C-44, as well as the bulk and shear moduli increase roughly linearly upon cooling. Deviations from such dependence are a result of impurities. Zener anisotropy factor is 0.697 at room temperature and decreases to 0.627 at 9.6 K, indicating increasing elastic anisotropy. The temperature dependence of C-12 is anomalous with no stiffening on cooling, which could be a result of different defect species influencing C-12 but not the other constants, possibly due to defect anisotropy. The values of elastic constants and anisotropy are compared at room temperature and below 10 K with the literature reporting experimental results and density functional theory calculations.
  • Article
    Hydrothermal Synthesis of Zeolite T From Bentonite Clay: Catalytic Applications and Molecular Docking Analysis
    (National Information & Documentation Centre-NIDOC, 2025) Taib, H.; Lefrada, L.; Belfennache, D.; Belghit, M. Y.; Benbouzid, M.; Yilmaz, S.; A.Ali, Mohamed
    Zeolites are essential materials in modern industries due to their uses as cation exchangers, selective adsorbents, and catalysts. In this study,we report novel procedures for producing zeolite T, which is distinguished by its round crystals that closely resemble Saharan flowers. An investigation was conducted on the hydrothermal synthesis of T zeolite in alkaline aqueous solutions without templates. Zeolite T crystals were synthesized via hydrothermal methods with clay-based aluminosilicate gel containing 1Al2O3, 25SiO2, 6.5Na2O, 2.25K2O, and 350 H2O. Zeolite crystals were formed at a temperature of 130 degrees C, with crystallization durations of 3 and 5 days, respectively, using processed natural bentonite clay as the starting material. A range of analytical methods, such as XRD, FTIR, Raman, SEM, ATD-EDX, BET, ATG, and NH3-TPD, were used to observe the crystallization stages of zeolite T grains.During the synthesis of Zeolite T, samples were collected at various intervals, with the samples taken after three and five days of reaction being particularly noteworthy. The T1 zeolite is identified as a mixture of T2 zeolite and other impurities present in the reaction medium, indicating that T1 zeolite serves as a precursor phase to T2 zeolite (T1 is a germination phase). The analysis revealed that a treatment temperature of 130 degrees C for 5 days is optimal. The nucleation of zeolite T from treated bentonite commenced after 3 days. The results indicate that zeolite T2, composed of uniform crystalline grains formed over 5 days, yields a mesoporous structure with a size of 1.35 mu m and a molar ratio of 1.78 between molar quantities of silica and aluminum of this zeolite (T Zeolite). An analysis of the BET (surface area) revealed a value of 95.75 m2g-1, accompanied by a pore volume of 0.010 cm3g-1. Moreover, the examination of TPD-NH3 desorption revealed a restricted occurrence of the acidic site of Br & oslash;nsted, while a significant number of acidic sites of Lewis were detected. The obtained crystalline zeolite T was examined for its ability to catalyze the Hantzsch reaction. In addition, T2 zeolite prepared was used as a catalyst in the synthesis of the 1,1'-(4-(5-bromo-2-thiophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)bis(ethan-1-one) (BTDDB) due to the acidity sites (Lewis and Br & oslash;nsted acid) in the structure of the zeolite. The result of the reaction has shown a good percentage in the synthetic of BTDDB The results of FTIR, UV, 13C NMR, and 1H NMR spectrum analyses revealed that the structure of the 1,4-dihydropyridine compound was well-defined, and the use of molecular docking and density functional theory (DFT) analysis revealed better performance in the inhibition of the macromolecular targets aminodeoxyfutalosine nucleosidase and DNA gyrase subunit B.