WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
Browse
119 results
Search Results
Now showing 1 - 10 of 119
Conference Object Applicability of Sound Criteria to Patients Undergoing Mastectomy(Springer, 2025) Ardila, Sara; Lupinacci, Kristin; Bayley, Erin; Cowher, Michael; Sabih, Quratulain; Steiman, Jennifer; Soran, AtillaArticle Citation - WoS: 8Protective and Therapeutic Effects of Milrinone on Acoustic Trauma in Rat Cochlea(Springer, 2019) Ceylan, Seyit Mehmet; Uysal, Erdal; Altinay, Serdar; Sezgin, Efe; Bilal, Nagihan; Petekkaya, Emine; Gulbagci, Mustafa EmreObjectiveThe aim of this study was to investigate the potential protective and therapeutic effects of milrinone, a specific phosphodiesterase (PDE) III inhibitor, on acoustic trauma-induced cochlear injury and apoptosis.MethodsA total number of 30 healthy Wistar albino rats were evenly divided into five groups as follows: group 1 was assigned as control group; group 2 and 3 were assigned as low-dosage groups (0.25mg/kg) in which milrinone was administered 1h before acoustic trauma (AT) and 2h after AT, respectively; group 4 and 5 were assigned as high-dosage groups (0.50mg/kg) in which the drug was administered 1h before AT and 2h after AT, respectively. Except control group, all treatment groups received a single dosage of milrinone for 5days. Distortion product otoacoustic emissions (DPOAE) measurements were recorded before AT as well as at second and fifth post-traumatic days. At the end of fifth day, all rats were sacrificed and the cochlea of the rats was removed for histopathological evaluation. In addition, the groups were compared in terms of apoptotic index via caspase-3 staining.ResultsIn terms of signal-to-noise ratio (SNR), there was no statistically significant difference among the groups following AT (p>0.05). After 5days of milrinone treatment, the best SNR values were found in group 5, though all groups did not statistically differ (p>0.05). In histopathological evaluation, vacuolization, inflammation, and edema scores in all treatment groups were statistically lower than those of the control group (p<0.05). In group 2 and 4 where the drug was administered before AT, the inflammation and apoptosis index was lower than those of group 3 and 5 where the drug was administered after AT (p<0.0001).ConclusionWe reveal that milrinone has a protective effect on cochlear damage in the experimental acoustic model of rats. This protective effect was more apparent following the pre-traumatic milrinone administration, and is associated with its effect on decreasing inflammation and apoptosis. Based on DPOAE measurements following AT, especially in the group 5 (high-dosage group), milrinone may also have a therapeutic effect.Article A Fiber-Driven Finite Element Model for Predicting Residual Limb Soft Tissue Deformation: Applications in Prosthetic Socket Design(Springer, 2025) Wang, Ling; Qiu, Ziyan; Tang, Lei; Huang, Fuhao; Wei, Pingping; Mihcin, Senay; Li, DichenPurposeChanges in residual limb volume and shape pose significant challenges in achieving and maintaining an accurate and comfortable fit for prosthetic socket. While numerous techniques for measuring residual limb volume have been proposed, their clinical application remains limited by insufficient resolution and the inability to perform in-socket measurements. To address this issue, this study develops a novel method for predicting residual limb soft tissue deformation to guide prosthetic socket design.MethodsA three-dimensional (3D) finite element (FE) model of the human thigh was developed to simulate the soft tissue deformation during daily activities, driven by muscle contraction to replicate natural biomechanics. The model included hard tissue and muscle components, with the muscle modeled as a structure of evenly distributed, contractile fibers that generate movement. Parameters controlling fiber contraction were iteratively adjusted to best match the calculated tissue deformation and that observed in physical muscle models.ResultsThe optimized FE model significantly improved the accuracy of predicting dynamic soft tissue deformation, with average errors of 0.83% and 1.86% for tissue expansion and contraction regions, respectively. For various gait patterns, the average differences in equivalent volume and cross-sectional area changes were also less than 0.83% and 1.86%, respectively.ConclusionThe model demonstrated consistent prediction accuracy across different gait data. The fiber-driven soft tissue model developed offers a valuable tool for pre-design simulations of prosthetic sockets and orthoses. It is equally applicable to other wearable devices that interface with the skin, providing a robust framework for improving device design and functionality.Article Reflection on Designing: Metacognitive Interventions to Enhance Metacognitive Awareness, Motivation, and Performance in Design Learning(Springer, 2025) Yazici, Gizem; Dogan, FehmiDesign education involves ill-defined problem-solving that demands both creativity and self-regulation. While metacognitive awareness significantly enhances learning outcomes and motivation, there is limited empirical evidence on how to systematically foster this skill in design studios. This study aims to investigate whether metacognitive interventions increase architecture students' metacognitive awareness levels, academic goal orientations, and design course success. In a quasi-experimental design, 84 third-year architecture students were divided into experimental (n = 58) and control (n = 26) groups. Pre-post-test data were collected using the MAI and AGOQ scales. Three structured interventions were implemented in the experimental group over six weeks. In the students who received the interventions, significant increases were observed in metacognitive awareness, mastery-performance goal orientation, and design course grades. In students with high awareness, mastery orientation, metacognitive awareness, and design course grades increased significantly, while in students with low awareness, metacognitive awareness and performance orientation increased. Pretest MAI and AGOQ scores accounted for 72.8% of the variance in grades, with MAI showing the strongest positive influence. Learning and proving orientations were moderately and positively correlated to grades, while avoidance orientation showed a moderate negative correlation. Metacognitive interventions enhance learning outcomes in design education by supporting metacognition and motivation.Article A Comprehensive Database and a New Model for the Axial Response of Heat-Damaged Concrete Before and After FRP Confinement(Springer, 2025) Akdag, Nefise; Demir, UgurIn this study, a total of 330 concrete specimens, compiled from existing experimental data, are systematically reviewed to assess their post-fire axial stress-strain behavior before and after circumferential confinement with fiber-reinforced polymers (FRPs). The selection criteria for the database are as follows: (i) studies had to be published in English, (ii) both lateral and axial ultimate strains must have been measured, (iii) the use of additional strengthening materials in combination with FRPs was excluded, (iv) only plain concrete specimens were considered, and (v) specimen dimensions and instrumentation details had to be explicitly reported. The dataset is structured to include heating/cooling and curing conditions, specimen properties, and FRP characteristics. Subsequently, the predictive accuracy of available models for post-fire axial strength and ultimate strain of concrete members, both before and after FRP confinement, is evaluated. The results based on the reviewed comprehensive database indicate that these models are inadequate in capturing the observed behavior in the experiments. As such, a new analytical model is developed based on the compiled dataset. The proposed model demonstrated reliable predictive performance in terms of post-fire axial response of concrete before and after FRP confinement while remaining user-friendly for practical engineering applications. This is done such that universal design guidelines on the behavior of heat-damaged concrete strengthened by FRP composites can be reliably formulated.Article Citation - WoS: 2Citation - Scopus: 1Isolation, Purification, Structural Characterization, and Encapsulation of Sulforaphane From Cabbage Seeds Using the Ionic Gelation Method(Springer, 2025) Oner, Beste; Aydin, Ozgun Koprualan; Okkali, Gaye Sumer; Sarikahya, Nazli Boke; Nadeem, Hilal Sahin; KaymakErtekin, FigenSulforaphane (SFN), a phytochemical with anticancer and antibacterial properties, is a secondary metabolite found in cabbage (both in the plants and seeds), a member of the Brassica (crusifer) family. However, pure sulforaphane is volatile, sensitive to pH, temperature, light, and oxygen, and is also only oil-soluble, limiting its stability and bioaccessibility. Therefore, encapsulation is required to enhance stability and control its release. In this study, sulforaphane-rich extracts were first obtained from cabbage seeds using a hybrid ultrasonic-microwave extraction method yielding 24.35%, with a sulforaphane content of 8202.68 mu g/g DM, followed by purification of sulforaphane through chromatography. Structural elucidation was performed using H-1-NMR, C-13-NMR, and QTOF LC/MS. The pure SFN (> 90% purity) was encapsulated using the ionic gelation method to improve its bioaccessibility and stability. Various coating material combinations, sodium alginate/chitosan and sodium alginate/pectin were evaluated for the encapsulation process. Fourier-transform infrared spectroscopy (FTIR) was used to investigate the relationship between the coating materials, and the most efficient combination was selected. Optimization of process variables using central composite rotatable design (CCRD) identified the optimal conditions: 1.41% sulforaphane-oil mixture, 0.18% chitosan, and 6.88 min waiting time. Under these conditions, microcapsules were produced with high encapsulation efficiency (76.02%) and low solubility (4.78%). & Idot;n vitro bioaccessibility studies further confirmed minimal sulforaphane release during the oral and gastric phases, with a low release in the intestinal phase. These results demonstrate the effectiveness of the encapsulation system in protecting sulforaphane under harsh gastrointestinal conditions.Article Task-Specific Dynamical Entropy Variations in EEG as a Biomarker for Parkinson's Disease Progression(Springer, 2025) Onay, Fatih; Karacali, BilgeUncovering the neuronal mechanisms un-derlying optimal behavioral performance is essential to understand how the brain dynamically adapts to changing conditions. In Parkinson's disease (PD), these neuronal mechanisms are disrupted and lead to impairments in motor coordination and higher-order cognitive functions. This study investigates neuronal dynamics during a lower-limb pedaling task by analyzing the dynamical entropy of EEG signals in healthy controls (HC), PD patients, and PD patients with freezing of gait (PDFOG). We examined both average entropy changes and entropy variability across trials to characterize task-specific neural adaptations across disease progression. Results showed that PD and PDFOG patients exhibited decreased levels of permutation entropy in frontal and parietal regions, which may be associated with loss of cognitive adapta-tion due to altered information processing. Additionally, Vasicek's entropy variability in both PD groups was significantly diminished in occipital and left frontal regions, suggesting reduced cognitive capacity to dy-namically allocate neuronal resources during task engagement. We extended this analysis to the classification of groups using LDA and SVM classifiers, where entropy-derived features achieved a classification accuracy of up to 96.15% when distinguishing HC from PDFOG patients. This dynamical entropic framework provides a novel approach for capturing neural complexity changes during task performance, revealing subtle cognitive-motor impairments in PD. Understanding the maintenance of cognitive information processing and flexibility in response to motor and cognitive task demands could be a useful tool to track PD diagnosis and progression in addition to resting-state analyses.Article Citation - WoS: 1Citation - Scopus: 1Fabrication of Electrospun Polycaprolactone Nanofibrous Mats Loaded With Purple Basil Extract (Ocimum Basilicum L.) as Colorimetric Ph Indicator Films(Springer, 2025) Erez, Elif; Eroglu, Ahmet Emin; Bayramoglu, BesteIntelligent packaging with colorimetric pH indicators revolutionizes traditional food packaging by enabling real-time food quality monitoring. This study used electrospinning to develop pH indicator films from polycaprolactone (PCL) incorporating purple basil extract (PBE). Nanofibrous films containing 0.2% PBE (PCLN_0.2PBE), 0.4% PBE (PCLN_0.4PBE), and 0.6% PBE (PCLN_0.6PBE) were fabricated using different electrospinning conditions. The PCLNs fabricated with a voltage of 20 kV and a flow rate of 1.6 mL/h exhibited the most uniform and bead-free morphology according to scanning electron microscopy. The chemical, thermal, mechanical, and wetting characterization of the films was performed by Fourier transform infrared spectroscopy, differential scanning calorimetry, thermal gravimetric analysis, texture analysis, and contact angle analysis, respectively. Both PCLN_0.4PBE and PCLN_0.6PBE films displayed fast (4-5 s) and clear color transitions (Delta E > 3.5) to successive pH buffers within the range critical for food deterioration, while they exhibited excellent color changes (Delta E > 5) for pH variations of at least two units. The PCLN_0.6 PBE film displayed a Delta E of similar to 5 in only 5 min of exposure to ammonia vapor, whereas PCLN_0.4PBE showed a similar color change for over 15 min. The interaction between the films and acidic and alkaline semi-solid foods was simulated using gelatin gels at pH 2.5 and 11, respectively. Both films displayed significant color transitions (Delta E > similar to 9) within 15 min of contact with the gels, with the response from PCLN_0.6 PBE being more pronounced. The color stability in both films was maintained for up to 14 days at 4 degrees C, offering potential early warnings against food spoilage. PBE release was evaluated against different food simulants. The highest release occurred in 50% ethanol; the films demonstrated resistance to 3% acetic acid. The findings indicate that electrospun PCL films integrated with PBE have a promising potential to serve as colorimetric pH indicators for monitoring the freshness of food products.Article Citation - WoS: 3Citation - Scopus: 2Cradle-To Life Cycle Assessment of Heavy Machinery Manufacturing: a Case Study in Türkiye(Springer, 2025) Üçtuğ, F.G.; Ediger, V.Ş.; Küçüker, M.A.; Berk, İ.; İnan, A.; Moghadasi Fereidani, B.Purpose: Amidst accelerated industrialization and urbanization, the surge in heavy equipment production, crucial for construction, mining, industry, and transportation, necessitates a comprehensive examination of its environmental implications from a sustainability standpoint. This study aims to scrutinize the environmental impacts of manufacturing forklifts and semi-trailers in Türkiye, employing the life cycle assessment (LCA) methodology. Methods: The life cycle assessment (LCA) methodology is the foundational framework for evaluating the environmental impacts associated with forklift and semi-trailer manufacturing. A cradle-to-gate approach was employed. CCaLC2 software alongside the Ecoinvent 3.0 database and CML LCIA methodology was used. Results: The carbon footprint analysis reveals that the production of a single forklift and semi-trailer generates 10.8 tons CO2eq. and 24.9 tons CO2eq. of emissions, respectively. Considering the mass of the machinery, these figures translate to 2.8 ton CO2eq./ton machinery and 1.57 ton CO2eq/ton machinery for the forklift and semi-trailer, respectively. These results were found to be consistent with values reported for similar (but not identical) heavy machinery. Notably, the predominant share of environmental impact stems from raw material acquisition for both products, with subsequent contributions from various production stages. Steel utilization emerges as the primary contributor to all environmental impact categories, constituting an average contribution of 75%. Noteworthy exceptions include the acidification potential of forklift production, where the incorporation of the engine emerges as the primary hotspot with a significant 38% contribution. Conclusions: The findings present the environmental footprint associated with forklift and semi-trailer manufacturing, emphasizing the pivotal role of raw material acquisition, particularly steel utilization. Insights derived from this environmental impact assessment provide invaluable guidance for enhancing environmental sustainability. Decision-makers and industry stakeholders can leverage these conclusions to implement targeted measures, such as exploring alternative materials or refining production processes, to mitigate the environmental consequences of resource-intensive heavy equipment manufacturing, aligning with broader sustainability objectives. © The Author(s) 2025.Article Citation - WoS: 3Citation - Scopus: 3Hybrid Silica Aerogels From Bridged Silicon Alkoxides: Ultralow Thermal Conductivity for Low-Temperature Applications(Springer, 2025) Abebe, A. M.; Biesuz, M.; Vakifahmetoglu, C.; Cassetta, M.; Soraru, G. D.Hybrid silica aerogels are promising materials for thermal insulation applications. Highly porous aerogels were synthesized from bridged bis(triethoxysilyl)methane BTEM and triethoxysilane TREOS silicon alkoxides via the sol-gel process. The carbon content in the hybrid aerogels decreased with increasing amounts of TREOS. Crack-free monolith aerogels were synthesized through supercritical drying, which is crucial for thermal and optical investigations. The aerogels are characterized by high BET surface areas ranging from 700 to 1400 m(2)/g, pore volumes between 2.0 and 10.5 cm(3)/g, and a maximum porosity of 95%. The thermal conductivity of the aerogels at room temperature was measured via a hot disk apparatus. The materials exhibited ultralow thermal conductivity, reaching a minimum value of 15 mW/mK. This value ranks among the lowest reported values for silica-based aerogels in the literature. Optical transmittance measurements indicated high transparency, exceeding 80% in the visible region. Therefore, these exceptional properties of low density, high optical transparency, and low thermal conductivity make these materials promising candidates for transparent insulation applications.