WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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Now showing 1 - 10 of 19
  • Article
    Improving Doppler Radar Performance through Optically-Reconfigurable Unequal Power Division with Semi-Analytical Approach
    (Taylor & Francis Ltd, 2025) Karatay, Anil; Atac, Enes; Dinleyici, Mehmet Salih; Yaman, Fatih
    The improvement of the signal-to-noise ratio (SNR) of Doppler radar systems, enabling the detection of targets at greater ranges even with limited power, has been a longstanding focus of research. However, while key limitations such as low target reflectivity and environmental interference are often addressed, the impact of efficient use of the input power remains an overlooked, yet crucial factor in overall sensitivity. Additionally, the power allocation needs to be examined from an analytical perspective for further enhancement. In this study, we present a novel measurement approach, utilizing both semi-analytical analysis and experimental methods, to improve the performance of a dual-antenna CW Doppler radar through the use of an optically reconfigurable unequal microwave power divider which provides well-directed power utilization. Comprehensive grid searches, supported by an analytical approach and considering various loss and noise scenarios, demonstrate the capability of the proposed reconfiguration method. In the Doppler radar experiments where the pendulum and servo motor were used as targets, an SNR increase of 3.04 and 2.11 dB in the radar signal was observed with the proposed method, respectively. This noticeable improvement in the SNR of the time-frequency plots indicates an enhancement in the measurement performance. The unequal power allocation enabled continuous detection of target motion with minimal signal loss, lowering the minimum detectable power level by more than 2 dB compared to the equal power division case. The experimental results show that integrating an optically reconfigurable microwave power divider into the Doppler radar system increases precision in velocity measurements.
  • Article
    Enhancement of Corchorus Olitorius L. on Osteogenic Differentiation of MC3T3-E1 Pre-Osteoblast Cells by Increasing Alkaline Phosphatase and Hydroxyproline
    (Taylor & Francis Ltd, 2025) Ertugruloglu, Pinar; Baris, Elif; Okkali, Gaye Sumer; Boke Sarikahya, Nazli
    Corchorus olitorius L. (jute mallow or molehiya) belongs to the Malvaceae family valued for its nutritional and medicinal properties. In this study, the potential to enhance osteogenesis in MC3T3-E1(Murine Calvaria-derived 3T3 Subclone E1) pre-osteoblastic cells was investigated to support bone formation and mineralisation. Leaf ethanolic extract was prepared and applied to MC3T3-E1 cells. Osteogenic effects were evaluated through three methods: MTT assays for cell viability, Alizarin Red S staining for calcium deposition, enzymatic analyses for alkaline phosphatase (ALP) and hydroxyproline (HYP). A non-cytotoxic concentration of C. olitorius extract (0.5 mg/mL) significantly increased ALP and HYP levels, promoting osteogenic differentiation in both undifferentiated and differentiated cells. HYP levels were notably elevated in differentiated cells. The findings suggested that C. olitorius extract may be a promising natural agent for enhancing bone health, warranting further in vivo and clinical studies to confirm its therapeutic potential.
  • Article
    A Systematic Evaluation of Computational Tools for Layout Generation: The Case of Emergency Departments
    (Taylor & Francis Ltd, 2025) Gulec, Ece; Kasali, Altug; Ekici, Berk
    The configuration of Emergency Department (ED) layouts requires adherence to strict guidelines and codes to achieve certain efficiency, accuracy, and safety measures. Considering the context of ED space planning, integrating computational design can cope with the complexity of floor plan generation due to its rule-based and data-driven nature. This paper presents a comparative analysis of existing plan generation plug-ins to assess their methodological approaches, input requirements, and output effectiveness in ED design. The systematic analysis intends to determine their suitability for automating ED plan generation while ensuring compliance with healthcare guidelines and regulations. The findings highlight the strengths and limitations of various plug-ins, offering insights into their applicability for optimizing spatial configurations, workflow efficiency, and patient flow management. This research contributes to advancing computational design methods in healthcare architecture, demonstrating whether and how automation can enhance precision and efficiency in complex planning tasks.
  • Article
    Enhanced Catalytic Performance of Rhizomucor Miehei Lipase on Di-N and Diethylhexyl Phthalates: Insights Into Substrate Specificity and Immobilization Strategy
    (Taylor & Francis Ltd, 2025) Balci, Esin; Rosales, Emilio; Curras, Marta Pazos; Sofuoglu, Aysun; Sanroman, M. A.
    Di-n-butyl (DnBP) and Diethylhexyl Phthalates (DEHP), known as potential endocrine disruptors, are priority pollutants categorized by many regulatory agencies. Enzymatic degradation is a green and efficient approach to remove PEs in the environment. In this study, the DnBP and DEHP degradation performance of Rhizomucor miehei lipase (palatase) in free and immobilized forms on Halloysite nanoclays (HNCs) in an aqueous system was investigated. Upon enzyme immobilization, the alterations in the palatase's secondary structure were examined using the circular dichroism (CD) analysis. The binding affinity of DnBP and DEHP to palatase was evaluated with molecular docking approaches. The enzyme's immobilization efficiency and relative activity were found to be 80.3% and 87.8%, respectively. CD results revealed that palatase retained its secondary structure to a significant extent. HNCs-palatase (HNCs-P) exhibited a high stability, as the structural integrity of palatase was mostly preserved. Both free palatase (FP) and HNCs-P fully degraded DnBP and DEHP (100 mg/L) to phthalic acid and a degradation pathway of DnBP and DEHP was suggested. Immobilization prevented the enzyme inhibition caused by the accumulation of metabolites. After seven consecutive uses, HNCs-P was still able to degrade DnBP (63.3%) and DEHP (72.8%). Molecular docking results showed that DEHP had a higher affinity for palatase than DnBP. This study suggests that enzyme immobilization onto HNCs can increase their stability and catalytic performance. FP and HNCs-P effectively hydrolyse ester bonds responsible for phthalate toxicity. Considering their high efficiency, FP and HNCs-P can be used as potential phthalate degraders in various environmental remediation processes.
  • Article
    Analytical Techniques for Non-Relativistic Particles in the Presence of Topological Defects and External Potentials: Applications to Diatomic Molecules
    (Taylor & Francis Ltd, 2025) Joseph, Gabriel Wirdzelii; Targema, Terkaa Victor; Oyewumi, Kayode John; Omugbe, Ekwevugbe; Ajulo, Kayode Richard; Gabriel, Ochoche; Zoe, Heeseung
    In this paper, we examine the effects of point-like and cosmic string topological defects on non-relativistic particles confined within external potentials using analytical methods. The external potentials under consideration include the Hellmann-Kratzer potential, the standard Kratzer potential, the energy-dependent Kratzer potential, and the modified Kratzer potential. The modified Kratzer potential is employed to illustrate the impact of topological defects on diatomic molecules, demonstrating that these defects impose significant constraints on the molecules. In all defect types, the depth of the effective potential increases with increasing curvature. In these regions, molecules become trapped and experience a substantial reduction in energy in the case of point-like defects. Conversely, when particles propagate in a cosmic string background, their energy increases. When the constraints imposed by the topological defects on these molecules are removed, the results obtained in this study align well with existing literature. Thus, we establish beyond reasonable doubt the effects of topological defects on non-relativistic particles and, consequently, on diatomic molecules, which arise from the geometry of these defects. Additionally, we have employed analytical methods to obtain the solutions without introducing any modification to the centrifugal term. The approach is straightforward, highly efficient, and effective.
  • Article
    Dam Body Sediment Movement on Rough Bed Downstream Due to Earthfill Dam Break
    (Taylor & Francis Ltd, 2025) Aksoy, Aysegul Ozgenc; Dogan, Mustafa; Tayfur, Gokmen
    This study investigated movement of flow and sediment due to earthfill dam failure induced by piping and overtopping, using 12.8 m laboratory flume. Dam (60 cm high, 202 cm base width) was built in three zones with two sediment sizes, and downstream channel included a rough bed of cubic blocks. Water levels were monitored with sensors, and final sediment profiles were mapped via laser scanning. Results showed that dam body eventually collapses (in 265 s after the piping, and in 100 s after the overtopping start) while flood flow carries a great portion of its sediment away. Sediment spreading occurred all over downstream area with significant variation in non-uniform thickness (15 cm to 1 cm). In the residential area, the sediment depth variation ranged from 12 cm to 6 cm. The blocks were submerged under muddy flow in both modes of failures. Higher flow levels (22 cm) were observed over smooth bed than rough bed (15 cm), in overtopping break. This was almost the opposite in the piping failure mode (13 cm in smooth, and 15 cm in rough bed case). These findings highlights the dominant role of failure mechanism and bed roughness in sediment transport and flood dynamics.
  • Article
    Nanostructured Ox-MWCNT-Ppy-Au Electrochemical Sensor for Ultralow Detection of Retrorsine and Evaluation of Its Cytotoxic Effects on Liver Cells
    (Taylor & Francis Ltd, 2025) Akturk, Ezgi Zekiye; Njjar, Muath; Ata, Melek Tunc; Kaya, Ahmet; Akdogan, Abdullah; Onac, Canan
    This study presents the development of a novel retrorsine (RTS)-imprinted sensor utilizing oxidized multi-walled carbon nanotubes (Ox-MWCNTs), polypyrrole (PPy), and gold nanoparticles (AuNPs), employing square wave voltammetry for the sensitive and selective detection of RTS which causes oxidative-stress and DNA damage. The fabricated Ox-MWCNT-PPy-AuNP sensor demonstrated a surface-area of (0.218 cm2) is 4.25 times larger than a bare glassy carbon electrode, with a low charge transfer resistance (10.9 Omega), enhancing electron transfer kinetics. The sensor showed excellent sensitivity in detecting retrorsine, with a limit of detection of 0.035 nM in synthetic matrices and -0.030 nM in HepaRG cell culture medium. Toxicity assays in HepaRG cells revealed dose-dependent oxidative-stress, with glutathione levels decreasing from 23.08 +/- 0.21 mu mol/109 to 21.21 +/- 0.02 mu mol/109 at 35 mu M retrorsine. Concurrently, GSSG levels increased from 1.32 +/- 0.26 mu mol/109 to 2.22 +/- 0.02 mu mol/109. DNA-damage assessed via comet assay, showed significant increases in tail-moment (2.53 mu m) and tail-migration (16.13 mu m). Oxidative DNA-damage, indicated by 8-OHdG levels, increased significantly from 0.29 +/- 0.02 ng.mL- (control) to 0.47 +/- 0.07 ng.mL- at 35 mu M retrorsine. These findings demonstrate the sensor's effectiveness for retrorsine detection and its applicability in toxicological studies. The integration of nanomaterial engineering and molecular imprinting provides a highly sensitive, selective, and eco-friendly solution for monitoring toxic agents and assessing their biological impacts.
  • Article
    Citation - WoS: 2
    Citation - Scopus: 2
    Charting the Landscape of Design Cognition: Bridging the Gap Between Design Cognition and Cognitive Science
    (Taylor & Francis Ltd, 2025) Ata, F. Zeynep; Dogan, Fehmi
    This study examines the trajectory of cognitive studies on design processes (DesCog), charting its scientific landscape and interactions with cognitive science (CogSci). First, the study delineates the boundaries of DesCog within all published scholarly works. The analysis indicates that DesCog is a focused field with lesser impact on other fields, showing divergent bibliographic positions and connections for 'design cognition' and 'design thinking'. Second, the longitudinal evolution of DesCog is identified as gradually becoming more diverse and more connected. Third, DesCog's foundational connections to CogSci demonstrate that the relationship is spontaneous rather than following 'generalising interdisciplinarity' aims. The analysis indicates a unidirectional flow from CogSci to DesCog, with occasional reciprocal interactions. The volume and diversity of CogSci literature cited by DesCog appear narrow, and most cited publications are based on the information-processing theory of cognition. Fourth, the study identifies common themes at the intersection of two fields, demonstrating that creativity has been a focal theme for both since earlier studies. Finally, the individual impact of CogSci researchers on DesCog highlights the significance of Simon and Newell's influence. The study contributes to reflections on DesCog's knowledge production, underlining unidirectional knowledge flows from CogSci to DesCog and partial theoretical connections within the field.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    Adaptive Reuse of Industrial Heritage in Crises Zones: the Soap Factories in the Levant
    (Taylor & Francis Ltd, 2025) Saifi, Yara; Zawawi, Zahraa; Yuceer, Hulya
    This paper articulates critical considerations for policies related to the adaptive reuse of industrial heritage, particularly in contexts affected by crises, such as conflicts, wars, and natural disasters using the soap factories of the Levant as a case study. It critically investigates the role of adaptive reuse in conserving industrial heritage buildings impacted by crises. The Levant provides a unique context for examining the intersection of cultural heritage and resilience; soap factories, reflective of the region's olive-oil-rich history and industrial legacy dating back to the 18th century, symbolise the conservation challenges and opportunities posed by ongoing regional conflict. The study systematically analyses existing literature on adaptive reuse and questions conventional paradigms in crisis environments, particularly the suitability of standard transformations such as converting industrial heritage into museums or exhibition spaces. Instead, it aims to broaden the dialogue on adaptive reuse by offering context-sensitive policy recommendations. These strategies balance the imperatives of heritage conservation, sustainable development, and contemporary community demands, contributing to a nuanced understanding of industrial heritage preservation in crisis-affected regions.
  • Article
    Review of the Relationship Between Growth Hormone and SARS-CoV-2 Infection
    (Taylor & Francis Ltd, 2025) Rasmi, Yousef; Kirboga, Kevser Kubra; Roshanravan, Neda; Tekin, Burcu; Jalali, Ladan; Ghazizadeh, Farid
    Recent evidence suggests that SARS-CoV-2 is associated with the endocrine system, particularly growth hormone (GH). GH modifies immune responses and its deficiency could be responsible for the uncontrolled immunity that occurs in severe cases of COVID-19. Recent research shows that patients suffering from lung complications have significantly lower levels of GH and insulin-like growth factor-1 (IGF-1), which are proportionate to the severity of the disease. This relationship supports the hypothesis that GH regulates the immunity and inflammatory processes of the SARS-CoV-2 virus. However, variables such as age, gender, and comorbidities, such as diabetes and obesity, which are associated with lower GH levels, are strong predictors of COVID-19 outcomes. Older individuals and men, who tend to have lower GH levels, are disproportionately represented among severely ill patients. The available evidence suggests that GH supplementation therapy should be evaluated as a supportive measure to reduce the severity of the disease in high-risk individuals. The main goal of the research is to understand how COVID-19 is related to GH so that researchers can identify new mechanisms of pathology and develop better solutions for patients.