WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article Encapsulation of IR783 in UiO-66 MOFs for Improved Photodynamic Efficacy Against Breast Cancer Cells(OICC Press, 2025) Sahinoglu, Sinem; Sanli-Mohamed, GulsahBreast cancer remains the most prevalent malignancy among women worldwide, underscoring the need for innovative therapeutic strategies beyond conventional modalities. Photodynamic therapy (PDT) offers a non-invasive approach that leverages light-activated photosensitizers to induce reactive oxygen species (ROS)-mediated tumor cell death. IR783, a near-infrared fluorescent (NIRF) heptamethine cyanine dye, has shown promise as a theranostic agent in cancer therapy due to its tumor-selective uptake and pro-apoptotic effects. However, its clinical potential is hindered by poor stability, rapid dissociation in polar environments, low quantum yield, and suboptimal tumor accumulation. In this study, we developed a multifunctional nanoplatform by encapsulating IR783 into UiO-66, a zirconium-based metal-organic framework (MOF), to enhance the delivery and photodynamic performance of the dye (IR783@UiO-66). The system was structurally characterized, and its biocompatibility and drug release profiles were evaluated. In vitro experiments were conducted to assess the cytotoxic and phototoxic effects of IR783, UiO-66, and IR783@UiO-66 on breast cancer cell lines (MCF-7, MDA-MB-231) and normal breast epithelial cells (MCF-10A), under LED irradiation at varying light intensities (18-144 J/cm2) and exposure durations (7.5-60 min). The results demonstrated that IR783@UiO-66 significantly reduced cancer cell viability in a dose-and light-dependent manner while sparing normal cells. Free IR783 showed slightly higher phototoxicity, attributed to differences in release kinetics and loading efficiency. UiO-66 alone exhibited negligible cytotoxicity under irradiation, confirming its safety profile. This study highlights the potential of UiO-66 as a promising nanocarrier for enhancing IR783-mediated PDT, offering a synergistic strategy for targeted and efficient breast cancer therapy.Article A Systematic Evaluation of Computational Tools for Layout Generation: The Case of Emergency Departments(Taylor & Francis Ltd, 2025) Gulec, Ece; Kasali, Altug; Ekici, BerkThe configuration of Emergency Department (ED) layouts requires adherence to strict guidelines and codes to achieve certain efficiency, accuracy, and safety measures. Considering the context of ED space planning, integrating computational design can cope with the complexity of floor plan generation due to its rule-based and data-driven nature. This paper presents a comparative analysis of existing plan generation plug-ins to assess their methodological approaches, input requirements, and output effectiveness in ED design. The systematic analysis intends to determine their suitability for automating ED plan generation while ensuring compliance with healthcare guidelines and regulations. The findings highlight the strengths and limitations of various plug-ins, offering insights into their applicability for optimizing spatial configurations, workflow efficiency, and patient flow management. This research contributes to advancing computational design methods in healthcare architecture, demonstrating whether and how automation can enhance precision and efficiency in complex planning tasks.Article Citation - WoS: 2Semantic Communications in 6G: Coexistence, Multiple Access, and Satellite Networks(IEEE-Inst Electrical Electronics Engineers Inc, 2025) Ahmed, Ishtiaque; Sun, Yingzhuo; Fu, Jingwen; Kose, Alper; Musavian, Leila; Xiao, Ming; Ozbek, BernaThe exponential growth of wireless users and bandwidth constraints necessitates innovative communication paradigms for next-generation networks. Semantic Communication (SemCom) emerges as a promising solution by transmitting extracted meaning rather than raw bits, enhancing spectral efficiency and enabling intelligent resource allocation. This paper explores the integration of SemCom with conventional Bit-based Communication (BitCom) in heterogeneous networks, highlighting key challenges and opportunities. We analyze multiple access techniques, including Non-Orthogonal Multiple Access (NOMA), to support coexisting SemCom and BitCom users. Furthermore, we examine multi-modal SemCom frameworks for handling diverse data types and discuss their applications in satellite networks, where semantic techniques mitigate bandwidth limitations and harsh channel conditions. Finally, we identify future directions for deploying semantic-aware systems in 6G and beyond.Article Citation - WoS: 7Design Education for Adaptive Reuse(Archnet-ijar, 2010) Eyuce, Ozen; Eyuce, AhmetBuiltform is subject to various types of obsolences in the course of time. Among these functional obsolesences, taking place as an outcome of ever changing modes of production and consumption, are of crucial importance so far as their fate of existing urban fabric is concerned. Defunct buildings become derelict and often subject to demolition which amounts to the eradication of the collective memory. In this connection the process of adaptive reuse can be defined as the task of adjusting functionally obsolete buildings for new program requirements through building conversion. Adaptive reuse projects entail not only alterations within the boundaries of an existing building envolope but also radical changes/transformations in the space configuration so as to accomodate the new set of functional requirements. Therefore, the development of an architectural design scheme in the light of potentials offered and the constraints imposed by an existing architectural entity is essential. Although adaptive reuse projects require case specific approaches depending on the peculiarities of the original structure three main areas of concern can be discerned during the elaboration of the design scheme. These areas of concerns are the space configuration, tectonic aspects of the context within which the project will be realized. The paper addresses itself to the elucidation of these concern areas and the interrelations with the final scheme.Article Citation - WoS: 1Citation - Scopus: 1New Buildings in Historic Settings: Revisiting Renzo Piano's Design Approach(Routledge Journals, Taylor & Francis Ltd, 2025) Demir, Hatice Aysegul; Yuceer, HulyaContemporary design in historic settings is a controversial issue where it impacts on an existing historic context. Conservation charters and scholarly literature on architectural designs within the historic environment provide preliminary insights and guidance that necessitate further elaboration and development. The aim of this study is to generate a more detailed and clearer insight into design strategies that inform the design of new buildings in historic locations through the work of the architect Renzo Piano. From the Centre Pompidou to his most recently built & Idot;stanbul Modern, he has seven new designs in the cities of Paris, Valetta, Athens, Beirut, and & Idot;stanbul. These buildings, six of which are in the settings of UNESCO World Heritage Sites, the seventh within the historic site of Beirut, are described individually to trace the architect's design approach. Seven categories have been identified, from the use of an existing square to the scale, form, view creation, transparency preferences, opening designs, and colour choices revealing strategies have been found compatible with their historic settings. By listing them, seven core principles are proposed as policy guidelines.Article Citation - WoS: 1Citation - Scopus: 2Co-Designing of Public Space for Urban Design Students Using Citizen-Generated Data(Taylor & Francis Ltd, 2025) Ozden, Pelin; Muller, Johannes; Velibeyoglu, KorayThis study describes the co-design process, which includes the citizens' spatial experiences, needs, and wishes, through participatory digital design tools in urban design. The paper draws on a case study for co-design practices for leftover public space; Re-shaping K & uuml;& ccedil;& uuml;k Park urban void in Bornova, Izmir, Turkey. The methodology used in this study is a further improvement of 'Citizen Design Science' and its tool Qua-Kit (a map-based e-participation tool), which originated from Future Cities Laboratory (FCL) in ETH Zurich. The toolkit allows users to move geometries in given urban spaces and enables non-expert participants to express their ideas for the urban area through design. Departing from conventional urban design approaches, the shaping of the urban realm became a democratic process in which all stakeholders participated as co-designers. The study utilises objective and subjective design data, offering a novel perspective on urban design education and the profession. The educational experiment showed that participants could contribute their experiences and opinions through active design tools and the development process in co-designing public spaces.Article Citation - WoS: 6Citation - Scopus: 6Evaluating the Impact of Nature-Based Solutions on the Provision of Water-Related and Water-Dependant Ecosystem Services(Elsevier Inc., 2024) Marijuan, Raquel; Diez, Barbara; Pelaez-Sanchez, Sara; Iglesias, Jesus; Sirin, Basar; Baba, Alper; Sanchez, RaulWater scarcity is a pressing issue in the Mediterranean region, exacerbated by overuse of resources for agriculture and the impacts of climate change. Addressing this challenge requires improved water cycle management and the adoption of Nature-based Solutions (NbS) to enhance infrastructure efficiency and sustainability. With the aim of promoting the implementation and assessment of NbS, we have developed a monitoring framework that integrates the assessment of ecological, socio-economic and cultural aspects under the umbrella of the IUCN Global Standard for NbS. A list of Key Performance Indicators (KPIs) was selected following standard methodologies. We have applied the framework to five case studies in the Mediterranean region to evaluate its efficiency to assess NbS tailored to local challenges and contexts. As part of the monitoring framework, we used the IUCN self-assessment tool for the Global Standard for NbS, demonstrating adherence of 50-75 % across all case studies. Common KPIs were identified, streamlining monitoring efforts and providing guidance from the design phase onwards. Our monitoring framework offers a comprehensive approach to evaluating NbS interventions, ensuring alignment with global standards and enhancing resilience in water management. By integrating the IUCN Global Standard, it provides robust guidance for future execution, contributing to sustainable water resource management in the Mediterranean and beyond.Conference Object Citation - WoS: 7Citation - Scopus: 6Semantic Pose Verification for Outdoor Visual Localization With Self-Supervised Contrastive Learning(IEEE, 2022) Guerrero, Jose J.; Orhan, Semih; Baştanlar, YalınAny city-scale visual localization system has to overcome long-term appearance changes, such as varying illumination conditions or seasonal changes between query and database images. Since semantic content is more robust to such changes, we exploit semantic information to improve visual localization. In our scenario, the database consists of gnomonic views generated from panoramic images (e.g. Google Street View) and query images are collected with a standard field-of-view camera at a different time. To improve localization, we check the semantic similarity between query and database images, which is not trivial since the position and viewpoint of the cameras do not exactly match. To learn similarity, we propose training a CNN in a self-supervised fashion with contrastive learning on a dataset of semantically segmented images. With experiments we showed that this semantic similarity estimation approach works better than measuring the similarity at pixel-level. Finally, we used the semantic similarity scores to verify the retrievals obtained by a state-of-the-art visual localization method and observed that contrastive learning-based pose verification increases top-1 recall value to 0.90 which corresponds to a 2% improvement.Article Citation - WoS: 5Citation - Scopus: 6Active Heat Transfer Enhancement by Interface-Localized Liquid Dielectrophoresis Using Interdigitated Electrodes(Elsevier, 2022) Yenigün, Onur; Barışık, MuratWe introduced an active heat transfer control between graphene and water using interdigitated electrodes (IDEs). Oppositely charged co-planer electrodes embedded on a graphene surface created a non-uniform electric field. Resulted interface localized liquid dielectrophoresis (LDEP) perpendicular to surface enhanced the water/graphene coupling and decreased interfacial thermal resistance (ITR) substantially. We correlated the theoretical calculations of average electric field strength near surface with Kapitza values measured at corresponding electrode configurations. We obtained a unified linear variation of Kapitza as a function of average electric strength independent of electrode size and charge. By increasing the electric field strength, we measured up to 96% decrease of Kapitza near electrodes. Since the IDEs generated electric field was only interface localized, it required lower electrode charges than any parallel-plate capacitor systems. We showed that ITR remains effective in heat transfer behavior for systems as big as 100nm such that interface localized electric field can at least increase the heat removal 50% by eliminating the ITR from both graphene/water interfaces of a channel system. By converting hydrophobic few-layer graphene to super-hydrophilic condition with ultra-low Kapitza, current results are important for graphene-based materials considered for the solution of the thermal management problem of current and next generation micro/nano-electronics.Book Part Citation - WoS: 4Citation - Scopus: 8Advances in Model-Based Testing of Graphical User Interfaces(Academic Press Inc., 2017) Belli, Fevzi; Beyazıt, Mutlu; Budnik, Christof J.; Tuğlular, TuğkanGraphical user interfaces (GUIs) enable comfortable interactions of the computer-based systems with their environment. Large systems usually require complex GUIs, which are commonly fault prone and thus are to be carefully designed, implemented, and tested. As a thorough testing is not feasible, techniques are favored to test relevant features of the system under test that will be specifically modeled. This chapter summarizes, reviews, and exemplifies conventional and novel techniques for model-based GUI testing.