WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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  • Conference Object
    Analysis, Design, Test, and Devops in Microservice-Based Software Architectures: Results From Pakistan
    (Springer international Publishing Ag, 2024) Unlu, Huseyin; Soylu, Gorkem Kilinc; Ahmad, Isra Shafique; Demirors, Onur
    In today's software industry, Microservice-based Software Architecture (MSSA) has been a common practice and has been adopted by many companies. MSSA differs from traditional object-oriented architecture in several ways. The architecture moved away from being data-driven and evolved into a behavior-oriented structure. The usage of a single database is replaced by the structures in which each microservice is developed independently and has its own database. Therefore, adaptation demands software organizations to transform their culture. However, there is no de facto method for analyzing, designing, and testing systems for these architectures, similar to object-oriented analysis and design practices. This study aimed to understand how Pakistani software organizations undertake analysis, design, test, and DevOps processes in software projects adopting the MSSA paradigm. To achieve this goal, we surveyed 49 participants from various agile organizations in Pakistan, encompassing different roles and domains. The results reveal that Pakistani software organizations continue using familiar object-oriented analysis and design approaches. However, they have already started exploring event-oriented analysis and design methods for MSSA projects.
  • Article
    Citation - WoS: 3
    Citation - Scopus: 3
    Synthesis, Cytotoxicity, and Antibacterial Studies of 2,4,5,6-Substituted Hexahydro-1h
    (Wiley, 2023) Yetişkin, Egehan; Gündoğdu, Özlem; Mete, Derya; Celebioglu, Neslihan; Kara, Yunus; Şanlı-Mohamed, Gulsah
    In this study, synthesis of novel isoindole-1,3-dione analogues bearig halo, hydroxy, and acetoxy groups at the position 4,5,6 of the bicyclic imide ring was performed to examine their potential anticancer effects against some cell lines. A multistep chemical pathway was used to synthesize the derivatives. The cytotoxic effect of trisubstituted isoindole derivatives were evaluated by determining cellular viability using the MTT assay against A549, PC-3, HeLa, Caco-2, and MCF-7 cell lines. The C-2 selective ring-opening products were obtained from the ring-opening reaction of 5-alkyl/aryl-2-hydroxyhexahydro-4H-oxireno[2,3-e]isoindole-4,6(5H)-diones with nucleophiles such as chloride (Cl-) and bromide (Br-) ions. In addition, the ring-opening products halodiols were converted to their related acetates. The anticancer activity of synthesized isoindole-1,3-dione derivatives was investigated against HeLa, A549, MCF-7, PC3, and Caco-2 cells in vitro and resulted in varies cytotoxic effect depend on the group attached to the isoindole molecule. Furthermore, the evaluation of the antimicrobial action of trisubstituted isoindole derivatives against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria was assessed and found out selective inhibition of the both bacterial growth via different trisubstituted isoindole derivatives. The results of this work encourage further research on the potential utilization of trisubstituted isoindole derivatives as cytotoxic and antimicrobial agents.