TR Dizin İndeksli Yayınlar / TR Dizin Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7149
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Article Citation - WoS: 7Citation - Scopus: 12A Survey on Organizational Choices for Microservice-Based Software Architectures(TÜBİTAK, 2022) Ünlü, Hüseyin; Bilgin, Burak; Demirörs, Onur; 03.04. Department of Computer Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyDuring the last decade, the demand for more flexible, responsive, and reliable software applications increased exponentially. The availability of internet infrastructure and new software technologies to respond to this demand led to a new generation of applications. As a result, cloud-based, distributed, independently deployable web applications working together in a microservice-based software architecture style have gained popularity. The style has been a common practice in the industry and successfully utilized by companies. Adopting this style demands software organizations to transform their culture. However, there is a lack of research studies that explores common practices for microservices. Thus, we performed a survey to explore the organizational choices on software analysis, design, size measurement, and effort estimation when working with microservices. The results provide a snapshot of the software industry that utilizes microservices. We provide insight for software organizations to transform their culture and suggest challenges researchers can focus on in the area.Article Citation - WoS: 1Citation - Scopus: 1Selective Catalytic Hydrogenation of Cellulose Into Sorbitol With Ru-Based Catalysts(TÜBİTAK, 2022) Orak, Ceren; Sapmaz, Aycan; Orak, Ceren; Yüksel Özşen, Aslı; 01. Izmir Institute of Technology; 03.02. Department of Chemical Engineering; 03. Faculty of EngineeringSorbitol is one of the platform chemicals and can be produced from various renewable and sustainable sources via different processes. Hydrothermal liquefaction is an effective and promising approach to produce sorbitol, since the subcritical reaction media and appropriate catalysts provide a selective production of platform chemicals. In this study, sorbitol was produced from different renewable sources (cellulose and glucose) in the presence of Ru-based catalysts (Ru/SiO2, Ru/AC, Ru/SBA-15, and Ru/SBA-15-SO3) under subcritical conditions. The highest cellulose conversion was achieved as 90% in the presence of Ru/SBA-15-SO3 for 1 h of reaction duration. The highest sorbitol yield (%) by hydrothermal liquefaction of cellulose was obtained as 6.2% by using Ru/AC for 1 h of reaction duration. A total of 99.9% of glucose conversion was achieved in the presence of all catalysts. The highest sorbitol yield (%) by hydrothermal liquefaction of glucose was found as 3.8% for 1 h of reaction duration. Owing to the results of GC-MS analysis, the intermediate products were identified, and, thus, a reaction pathway was proposed.Article Citation - WoS: 6Citation - Scopus: 8A “sweet” Way To Increase the Metabolic Activity and Migratory Response of Cells Associated With Wound Healing: Deoxy-Sugar Incorporated Polymer Fibres as a Bioactive Wound Patch(TÜBİTAK, 2022) Dikici, Serkan; Dikici, Serkan; 03.01. Department of Bioengineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyThe selection of a wound dressing is crucial for successful wound management. Conventional dressings are preferable for the treatment of simple wounds. However, a bioactive wound dressing that supports wound management and accelerates the healing process is required when it comes to treating non-self-healing wounds. 2-deoxy-D-ribose (2dDR) is a small deoxy sugar that naturally occurs in human body. Although we have previously demonstrated that 2dDR can be used to induce neovascularisation and accelerates wound healing in vitro and in vivo, the literature on small sugars is conflicting, and the knowledge on how 2dDR achieves its biological activity is very limited. In this study, several small sugars including D-glucose (DG), 2-deoxy-D-glucose (2dDG), 2deoxy-L-ribose (2dLR) were compared to 2dDR by investigating their effects on the metabolic activities of both human dermal microvascular endothelial cells (HDMECs) and human dermal fibroblasts (HDFs). Then, for the first time, a two-dimensional (2D) scratch wound healing model was used to explore the migratory response of HDFs in response to 2dDR treatment. Finally, 2dDR was incorporated into Poly(3-hydroxybutyrate-co3-hydroxyvalerate) (PHBV) polymer fibres via electrospinning, and the metabolic activity of both types of cells in vitro was investigated in response to sugar release via Alamar Blue assay. The results demonstrated that 2dDR was the only sugar, among others, that enhances the metabolic activity of both HDMECs and HDFs and the migratory response of HDFs in a 2D scratch assay in a dose-dependent manner. In addition to direct administration, 2dDR was also found to increase the metabolic activity of HDMECs and HDFs over 7 days when released from polymer fibres. It is concluded that 2dDR is a potential pro-angiogenic agent that has a positive impact not only on endothelial cells but also fibroblasts, which take a key role in wound healing. It could easily be introduced into polymeric scaffolds to be released quickly to enhance the metabolic activity and the migratory response of cells that are associated with angiogenesis and wound healing.Article Citation - WoS: 14Citation - Scopus: 15Noncoding Rnas in Apoptosis: Identification and Function(TÜBİTAK, 2022) Erdoğan, İpek; Akgül, Bünyamin; Tüncel, Özge; Erdoğan, İpek; Akgül, Bünyamin; 04.03. Department of Molecular Biology and Genetics; 04. Faculty of Science; 01. Izmir Institute of TechnologyApoptosis is a vital cellular process that is critical for the maintenance of homeostasis in health and disease. The derailment of apoptotic mechanisms has severe consequences such as abnormal development, cancer, and neurodegenerative diseases. Thus, there exist complex regulatory mechanisms in eukaryotes to preserve the balance between cell growth and cell death. Initially, protein coding genes were prioritized in the search for such regulatory macromolecules involved in the regulation of apoptosis. However, recent genome annotations and transcriptomics studies have uncovered a plethora of regulatory noncoding RNAs that have the ability to modulate not only apoptosis but also many other biochemical processes in eukaryotes. In this review article, we will cover a brief summary of apoptosis and detection methods followed by an extensive discussion on microRNAs, circular RNAs, and long noncoding RNAs in apoptosis.Letter Prof. Dr. O. Yavuz Ataman(TÜBİTAK, 2021) Eroğlu, Ahmet Emin; Eroğlu, Ahmet Emin; 04.01. Department of Chemistry; 04. Faculty of Science; 01. Izmir Institute of TechnologyProf. Dr. O. Yavuz Ataman passed away on August 15, 2020, in Ankara. He was an academic as well as a social figure throughout his life. He had remarkable achievements in academy as a researcher, an educator, and an administrator. He was known for his unique approaches to the events in all aspects of life. With his beloved character, he was really special. With Prof. Ataman's passing away, the chemistry and especially analytical chemistry community have lost a very special member.