Chemical Engineering / Kimya Mühendisliği
Permanent URI for this collectionhttps://hdl.handle.net/11147/14
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Article Citation - WoS: 14Xenograft Tumor Volume Measurement in Nude Mice: Estimation of 3d Ultrasound Volume Measurements Based on Manual Caliper Measurements(Dokuz Eylül Üniversitesi, 2020) Barış, Mustafa; Kılıç Özdemir, Sevgi; Serinan, Efe; Çalışır, Meryem; Şimşek, Kürşat; Aktaş, Safiye; Yılmaz, Osman; Seçil, Mustafa; Kılıç Özdemir, Sevgi; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyObjectives: Volume measurement of subcutaneous xenograft tumors in nude mice models is an important metric to assess tumor growth or response to therapy. Manual calipers are widely used for this purpose. But the measurements with manual calipers may be inaccurate. Contrarily, three-dimensional (3D) ultrasonographic measurements give reliable and accurate tumor volume calculation. We aim to; evaluate the accuracy of common four formulas given in the literature to estimate xenograft tumor volumes based on manual caliper measurements and offer a new coefficient for a better estimation of the tumor volumes. Patients and Methods: Detailed manual diameter measurements of xenograft tumors were in 14 nude mice performed using Vernier caliper. Tumor volumes were calculated using the suggested formulas in the literature based on manual measurements. 3D ultrasound volume measurements were performed on same xenograft tumors using high resolution Vevo 2100 imaging system. To propose a new coefficient; means of ratio between manual and ultrasound volume measurement values were used. Also, data set was divided into two subgroups as tumor volume under 800 mm3 and over 800 mm3. New coefficients for each subgroup were defined. Results: Only with prolate ellipsoid formula there was no statistically significant difference between volume measurements with two methods (p=0,24). Our proposed formula (0,45 L*W*H) could estimate tumor volumes as good as prolate ellipsoid formula. Coefficient 0,35 and 0,81 in the same formula were found efficient in the selected subgroups. Conclusion: Using one common coefficient/formula for tumor volume estimation in any tumor size can be inaccurate. Appropriate coefficient should be chosen according to the dataset worked with.Book International Porous and Powder Materials Symposium and Exhibition Ppm 2013, 3-6 September 2013, Çeşme Izmir-Turkey(Organizing Committee of the International Porous and Powder Materials Symposium and Exhibition, 2013) Özdemir, Sevgi Kılıç; Polat, Mehmet; Kılıç Özdemir, Sevgi; Polat, Mehmet; Tanoğlu, Metin; Kılıç Özdemir, Sevgi; Polat, Mehmet; Tanoğlu, Metin; 03.10. Department of Mechanical Engineering; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyWe welcome you to the first of the International Porous and Powder Materials Symposium and Exhibition, PPM 2013. The idea of organizing a symposium on porous and powder materials owes its germination to the curiosity about the ‘other side of the fence’. We are all familiar of the mild surprise when we come accross with a research paper from a totaly unrelated field written in a completely different terminology but describing something pleasantly familiar. Just imagine the elation of a PhD student in ceramics who is trying to optimize the stability and plasticity of the green body reading about the double layer around a protein, of an environmental engineer who is attempting to flocculate a nasty sludge coming accross with the concept of aggregation of micellar structures or of a researcher in chemical engineering who is looking for the perfect catalyst seeing the SEM pictures of porous nanoparticles developed for drug delivery. The list could be extended with much better examples by the readers of this book. But the best set of words to describe these feelings is an awareness of wholeness and solidarity.