Chemical Engineering / Kimya Mühendisliği

Permanent URI for this collectionhttps://hdl.handle.net/11147/14

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  • Article
    Citation - WoS: 69
    Citation - Scopus: 77
    Novel Zein-Based Multilayer Wound Dressing Membranes With Controlled Release of Gentamicin
    (John Wiley and Sons Inc., 2019) Kimna, Ceren; Tamburacı, Sedef; Tıhmınlıoğlu, Funda
    Recently, functional multilayer scaffolds with controlled drug release ability come into prominence for wound healing applications to mimic the layered structure of skin tissue and prevent the possible infections at the defect site. In this study, controlled antibiotic releasing zein bilayer membranes were fabricated for treatment of acute skin infections. Gentamicin loaded fibers were prepared by electrospinning on the membrane surface. Membranes were characterized with scanning electron microscope, atomic force microscopy, Fourier transform infrared spectroscopy, contact angle, mechanical analysis, swelling, degradation, and water vapor permeability studies. In vitro cytotoxicity, cell attachment, and proliferation were investigated. Cell attachment on fiber layer was observed with fluorescence imaging. Fabricated fibers showed structural similarity to the skin tissue layers with a fiber diameter range of 350-425 nm and film thickness in the range of 311-361 mu m. Mechanical properties were found compatible with the skin tissue. In addition, membranes showed antimicrobial activity against Staphylococcus aureus and Escherichia coli. The sustained release was achieved with a cumulative release of 94%. Membranes did not show any cytotoxic effect. NIH/3T3 and HS2 cell lines were proliferated on each layer mimicking the multilayer skin tissue. Hence, zein-based bilayer membrane showed promising properties to be used as a potential antimicrobial wound dressing for skin tissue regeneration. (c) 2018 Wiley Periodicals, Inc.
  • Article
    Citation - WoS: 35
    Citation - Scopus: 40
    Olive Leaf Extract as a Crosslinking Agent for the Preparation of Electrospun Zein Fibers
    (John Wiley and Sons Inc., 2015) Erdogan, I.; Demir, M.; Bayraktar, O.
    Incorporating active agents, reinforcing structure by crosslinking, thus changing release properties, can be listed as possible modifications in preparation methods of biopolymer fibers. This study introduces oleuropein, major component of olive leaf extract (OLE), as a natural functional crosslinker for electrospun zein fibers, owing to its antioxidant and antimicrobial properties. Incorporation of OLE causes morphological and structural changes indicated by a decrease in fiber diameter up to 27%, an increase in intensity of NH bending region due to interaction with -OH groups and observation of characteristic oleuropein bands. Extract addition also enhances thermal stability. Zein fibers without OLE is fully degraded at 600C, whereas 10% of OLE loaded zein fibers is left undegraded. Fifty percent of initial phenolic content loaded into fibers is released which indicate the effect of OLE incorporation as accumulation of oleuropein. OLE-incorporated fibers immersed in PBS are less fused than pure zein fibers, due to the crosslinking effect. © 2014 Wiley Periodicals, Inc.