Chemical Engineering / Kimya Mühendisliği

Permanent URI for this collectionhttps://hdl.handle.net/11147/14

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  • Conference Object
    Effect of Ceria Nanoparticles Synthesis on Their Cytotoxicity Against Caco2 Cells in Vitro
    (Institute of Electrical and Electronics Engineers, 2014) Yelken, Gülnihal
    In recent year's cerium oxide has been used productively in various engineering and biological applications, such as solid oxide fuel cells, catalytic materials, solar cells and biomedical applications as biological antioxidants [1-4]. Aim of this study is to investigate effects of synthesis conditionsof nanoceria on cytotoxicity against CaCo2 (human colon adenocar-cinoma) Cells in vitro. The morphological and structural characterization of ceria nanopowders were performed by X-Ray Diffraction (XRD), Fourier Transform Infrared Spectra (FTIR), size distribution, electrokinetic analysis (zeta potential measurements), surface area. Cytotoxicity test using colon cancer cells showed that nanoceria have no cytotoxic effect against Caco-2 cells at low concentration and cytotoxicity change with respect to synthesis conditions. © 2014 IEEE.
  • Article
    Citation - WoS: 22
    Citation - Scopus: 24
    Optimization of Extraction Conditions for Active Components in Equisetum Arvense Extract
    (Ars Docendi, 2013) Uslu, Mehmet Emin; Erdoğan, İpek; Bayraktar, Oğuz; Ateş, Mehmet
    Response surface methodology was applied to predict optimum conditions for equisetum arvense extraction. Central composite design was used to monitor the effects of temperature, stirring speed, ethanol percent, extraction time, solid-liquid ratio on dependent variables such as, extract yield percent, total phenol content, total antioxidant capacity, silicic acid amount. According to the mathematical models obtained from the analysis, the highest values for yield percent, total phenol content, total antioxidant capacity and silicic acid amount were found to be 18.67 %, 123 mg gallic acid gr-1 dry weight extract, 1608 μM TEAC mg-1 dry weight extract and 0.0049 mg silicic acid mg-1 dry weight extract, respectively. The plant extracts were analyzed with HPLC to determine the phenolic content and compositional differences of extracts obtained at different extraction conditions. Plant extracts were also analyzed for their cytotoxic and antimicrobial activities. The high total antioxidant capacity and total phenolic content resulted in an increased cytotoxic effect on fibroblast cells. Equisetum arvense extracts showed antimicrobial activity against Staphylococcus epidermidis and Escherichia coli bacteria, however showed no effect against Candida albicans. © 2013 University of Bucharest.