Rectorate / Rektörlük
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Article Governing Authority Through Bureaucracy: Conflicts Over Bureaucratic Cadres and the Rise of Authoritarianism in the Late Ottoman Empire (1908-1913)(Routledge Journals, Taylor & Francis Ltd, 2024) İlter, MustafaThis article presents a historical analysis of how internal power struggles and conflicts among state actors can foster the development of authoritarian systems, particularly when a political network gains exclusive control over the bureaucratic apparatus through its authority over appointments and dismissals. Focusing on the intricate power struggles and factional rivalries surrounding gubernatorial appointments between 1908 and 1913, this article aims to provide an alternative approach to understanding how the Committee of Union and Progress (CUP) became the dominant governing force within the state apparatus, enabling it to pursue an authoritarian agenda.Article Ai-Assisted Survival Prediction in Colorectal Cancer: a Clinical Decision Support Tool(dergipark, 2021) Leblebici, Asım; Mısırlıoğlu, Hüseyin Koray; Koçal, Gizem Çalıbaşı; Ellidokuz, Hülya; Başpınar, YaseminPurpose: Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Accurate survival prediction is crucial for advanced-stage patients to optimize treatment strategies and improve clinical outcomes. This study aimed to develop an artificial intelligence-assisted clinical decision support system (CDSS) for survival prediction in CRC patients using clinical and genomic data from the Cancer Genome Atlas Colon Adenocarcinoma Collection (TCGA-COAD) dataset. Methods: Machine learning algorithms, including C4.5 Decision Tree, Support Vector Machines (SVM), Random Forest, and Naive Bayes, were employed to create survival prediction models. Clinical parameters and genomic data from key pathways, such as glycolysis/gluconeogenesis and mTORC1, were integrated into the models. The models were evaluated based on accuracy and performance. Results: The Random Forest algorithm achieved the highest accuracy (82.3%) when only clinical parameters were used. When clinical data were combined with gene expression data, the model’s accuracy increased further. The resulting models were incorporated into a user-friendly web interface, SurvCOCA, for clinical use. Conclusions: This study demonstrates the potential of AI-based tools to improve prognosis predictions in CRC patients. Further research is needed, with larger datasets and additional machine learning algorithms, to enhance clinical decision-making and optimize treatment strategies.Article General Purpose and Focused Invention, Market Value, and Productivity(2024) Dindaroğlu, BurakWe study returns to general purpose and focused invention at the firm level for a panel of manufacturing firms in the U.S. for the period 1976-1995, by studying their relationships with market value and Total Factor Productivity. We construct stocks of patents that lie at the two relevant tails of the distribution of the generality index (Trajtenberg et al., 1997; Henderson et al, 1998) to measure general purpose and focused invention at the firm level. In line with expectations, there is a market value premium to focused invention, and a productivity premium to general purpose invention. Estimates for the value of focus indicate that moving a single patent from the upper tail of the generality distribution to the lower tail would increase market value by .24×q million 1992 dollars on average, where q is Tobin’s q. The firm with the average general patent stock would gain 6.7×q million in market value if all its patents at the highest quartile of the generality distribution were moved to the lowest. In terms of the value of general purposeness, moving all its focused patents to the general category increases Total Factor Productivity by 2.3% to 2.8%, and five-year productivity growth by 3.9% to 5.2%, for the average firm. A potential implication is that corporate basic research is associated with significant long-term benefits in terms of productivity growth.Article An Empirical Study of Sequential Offer Bargaining During the Festival of Sacrifice(Elsevier, 2024) Dindaroğlu, Burak; Ertaç, SedaWe report results from a unique data set of real -life bargaining transactions collected from the market for livestock (sheep) before the Festival of Sacrifice (Eid al-Adha) in Izmir, Turkey. This market is characterized by frequent and aggressive bargaining, which occurs in the form of sequential price offers. We record bargaining transactions as they occur, and collect detailed information on the bargaining environment, as well as on the characteristics of buyers and sellers. We also elicit each seller's outside option by means of an incentive compatible mechanism and obtain a reported maximum willingness to pay from buyers. We particularly focus on aspects of the bargaining process, such as non -price communication. In different types of empirical analysis, results robustly indicate that the presence and content of communication matters, for the likelihood of a sale as well as concessions made. Specifically, buyer -side communication is associated with larger concessions from the seller and a higher probability of sale. The presence of a mediator during the negotiation is associated with a higher probability of sale as well, while it has no effect on prices. We also provide results on the relative importance of groups of variables for predicting bargaining outcomes, which can provide directions for further research in bargaining.Article Citation - WoS: 2Citation - Scopus: 3Nkx3.1 Expression Contributes To Epithelial-Mesenchymal Transition of Prostate Cancer Cells(American Chemical Society, 2023) Saydullaeva, Iroda; Debeleç Bütüner, Bilge; Korkmaz, Kemal SamiStudies demonstrate that inflammation synergizes with highgrade aggressive prostate tumor development and ultimately metastatic spread, in which a lot of work has been done in recent years. However, the clear mechanism of inflammation inciting prostate cancer remains largely uncharacterized. Our previous study has shown that the conditioned media (CM)-mediated LNCaP cell migration is partially correlated with the loss of expression of the tumor suppressor NKX3.1. Here, we continue to investigate the inflammation-mediated migration of prostate cancer cells, and the role of NKX3.1 in this process to gain insights into cell migration-related changes comprehensively. Earlier, the model of inflammation in the tumor micro environment have been optimized by our research group; here, we continue to investigate the time-dependent effect of CM exposure together with NKX3.1 changes, in which we observed that these changes play important roles in gaining heterogeneous epithelial-to-mesenchymal transition (EMT) phenotype. Hence, this is an important parameter of tumor progression; we depleted NKX3.1 expression using the CRISPR/Cas9 system and examined the migrating cell clusters after exposure to inflammatory cytokines. We found that the migrated cells clearly demonstrate reversible loss of E-cadherin expression, which is consistent with subsequent vimentin expression alterations in comparison to control cells. Moreover, the data suggest that the AR mediated transcriptional program also contributes to mesenchymal-to-epithelial transition (MET) in prostate cancer progression. Furthermore, the quantitative proteomic analysis showed that migrated subpopulations from the same cell line presented different phenotypes in which the proteins overexpressed are involved in cell metabolism and RNA processing. According to KEGG pathway analysis, the ABC transporters were found to be the most significant. Thus, the dynamic process of cellular migration favors diverse genetic compositions under changing tumor microenvironments. The different levels of invasiveness are supported by shifting the cells in between these EMT and MET phenotypes.Article Citation - Scopus: 1İzmir'in bir dağ köyü: Yamanlar ve Yamanlar Yörükleri üzerine etnotarihsel bir inceleme(Rector CIU Cyprus int Univ, 2023) Ustuk, OzanThis study examines the history, language, social, and economic transformation of the Yuruks living in the Yamanlar Village located in the Karsiyaka district, where there is relatively little information in the literature despite its proximity to the Izmir city center. Information collected from the Ottoman Era cemetery adjoining the village reveals that the Yamanlar Yuruks have lived here for at least 400 years. Mount Yamanlar, where the village is located, is of great importance because of its ancient history, as it witnessed the founding of Izmir (Smyrna). The social and economic lifestyle in the village has transformed as the city expanded toward residential areas atop Mount Yamanlar. The loss of traditional livelihood practices challenged the villagers and severely influenced their customs, which might be considered valuable pieces of cultural heritage. In this study, we conducted fieldwork, during which various data collection methods and techniques were employed to describe daily life in the village. Within the scope of this study, semi-structured and unstructured interviews were conducted with the local people, and an oral historical study was carried out. With this method, we aimed to present an ethnohistorical description of the Yamanlar Village by trying to establish a balance between the analysis of both written documents and oral data to make sense of the social and economic change it has undergone and to contribute to the literature on Izmir Yuruks.Article Citation - WoS: 13Evidence for Ww/Wz Vector Boson Scattering in the Decay Channel <i>l</I>νqq Produced in Association With Two Jets in Proton-Proton Collisions at √<i>s</I>=13tev(Elsevier, 2022) Karapınar, Güler; CMS Collaboration; Andrejkovic, J. W.; Bergauer, T.; Chatterjee, S.; Dragicevic, M.; Vetens, W.Evidence is reported for electroweak (EW) vector boson scattering in the decay channel l nu qq of two weak vector bosons WV(V = Wor Z), produced in association with two parton jets. The search uses a data set of proton-proton collisions at 13TeVcollected with the CMS detector during 2016-2018 with an integrated luminosity of 138fb(-1). Events are selected requiring one lepton (electron or muon), moderate missing transverse momentum, two jets with a large pseudorapidity separation and a large dijet invariant mass, and a signature consistent with the hadronic decay of a W/Zboson. The cross section is computed in a fiducial phase space defined at parton level requiring all parton transverse momenta p(T)> 10 GeVand at least one pair of outgoing partons with invariant mass mqq> 100 GeV. The measured and expected EW WVproduction cross sections are 1.90(-0.46)(+0.5)3 pb and 2.23(-0.11)(+0.08)(scale) +/- 0.05(PDF) pb, respectively, where PDF is the parton distribution function. The observed EW signal strength is mu EW= 0.85 +/- 0.12 (stat)(-0.17)(+0.19)(syst), corresponding to a signal significance of 4.4 standard deviations with 5.1 expected, and it is measured keeping the quantum chromodynamics (QCD) associated diboson production fixed to the standard model prediction. This is the first evidence of vector boson scattering in the l nu qq decay channel at LHC. The simultaneous measurement of the EW and QCD associated diboson production agrees with the standard model prediction. (C) 2022 The Author(s). Published by Elsevier B.V.Article Citation - WoS: 20Nuclear Modification of Y States in Ppb Collisions at Root S-Nn=5.02 Tev(Elsevier, 2022) Tumasyan, A.; Karapınar, GülerProduction cross sections of Y(1S), Y(2S), and Y(3S) states decaying into mu(+)mu(-) in proton-lead (pPb) collisions are reported using data collected by the CMS experiment at root S-NN= 5.02 TeV. A comparison is made with corresponding cross sections obtained with ppdata measured at the same collision energy and scaled by the Pb nucleus mass number. The nuclear modification factor for Y(1S) is found to be R-pPb(Y(1S)) = 0.806 +/- 0.024 (stat)+/- 0.059 (syst). Similar results for the excited states indicate a sequential suppression pattern, such that R-pPb(Y(1S)) > R-pPb(Y(2S)) > R-pPb(Y(3S)). The suppression of all states is much less pronounced in pPbthan in PbPbcollisions, and independent of transverse momentum p(T)(Y) and center-of-mass rapidity y(CM)(Y) of the individual Y state in the studied range p(T)(Y) < 30GeV/c and |y(CM)(Y)| < 1.93. Models that incorporate final-state effects of bottomonia in pPb collisions are in better agreement with the data than those which only assume initial-state modifications. (c) 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Article Citation - WoS: 1Citation - Scopus: 9Search for Heavy Resonances Decaying To Z (ν Ν ¯)v (q Q ¯ ′) in Proton-Proton Collisions at S =13 Tev(American Physical Society, 2022) Karapınar, Güler; CMS CollaborationA search is presented for heavy bosons decaying to Z(νν¯)V(qq¯′), where V can be a W or a Z boson. A sample of proton-proton collision data at s=13 TeV was collected by the CMS experiment during 2016-2018. The data correspond to an integrated luminosity of 137 fb-1. The event categorization is based on the presence of high-momentum jets in the forward region to identify production through weak vector boson fusion. Additional categorization uses jet substructure techniques and the presence of large missing transverse momentum to identify W and Z bosons decaying to quarks and neutrinos, respectively. The dominant standard model backgrounds are estimated using data taken from control regions. The results are interpreted in terms of radion, W′ boson, and graviton models, under the assumption that these bosons are produced via gluon-gluon fusion, Drell-Yan, or weak vector boson fusion processes. No evidence is found for physics beyond the standard model. Upper limits are set at 95% confidence level on various types of hypothetical new bosons. Observed (expected) exclusion limits on the masses of these bosons range from 1.2 to 4.0 (1.1 to 3.7) TeV. © 2022 CERN.Erratum Citation - Scopus: 2Erratum To: Measurement of the Top Quark Mass With Lepton+jets Final States Using Pp Collisions at S = 13 Tev(Springer Science and Business Media Deutschland GmbH, 2022) Sirunyan, A.M.; Karapınar, GülerIn this article the author name Luigi Calligaris was incorrectly written as A. Calligaris. The original article has been corrected. © CERN for the benefit of the CMS collaboration 2022.