Rectorate / Rektörlük
Permanent URI for this collectionhttps://hdl.handle.net/11147/6849
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Article Ai-Assisted Survival Prediction in Colorectal Cancer: a Clinical Decision Support Tool(dergipark, 2021) Leblebici, Asım; Mısırlıoğlu, Hüseyin Koray; Koçal, Gizem Çalıbaşı; Ellidokuz, Hülya; Başpınar, YaseminPurpose: Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Accurate survival prediction is crucial for advanced-stage patients to optimize treatment strategies and improve clinical outcomes. This study aimed to develop an artificial intelligence-assisted clinical decision support system (CDSS) for survival prediction in CRC patients using clinical and genomic data from the Cancer Genome Atlas Colon Adenocarcinoma Collection (TCGA-COAD) dataset. Methods: Machine learning algorithms, including C4.5 Decision Tree, Support Vector Machines (SVM), Random Forest, and Naive Bayes, were employed to create survival prediction models. Clinical parameters and genomic data from key pathways, such as glycolysis/gluconeogenesis and mTORC1, were integrated into the models. The models were evaluated based on accuracy and performance. Results: The Random Forest algorithm achieved the highest accuracy (82.3%) when only clinical parameters were used. When clinical data were combined with gene expression data, the model’s accuracy increased further. The resulting models were incorporated into a user-friendly web interface, SurvCOCA, for clinical use. Conclusions: This study demonstrates the potential of AI-based tools to improve prognosis predictions in CRC patients. Further research is needed, with larger datasets and additional machine learning algorithms, to enhance clinical decision-making and optimize treatment strategies.Article General Purpose and Focused Invention, Market Value, and Productivity(2024) Dindaroğlu, BurakWe study returns to general purpose and focused invention at the firm level for a panel of manufacturing firms in the U.S. for the period 1976-1995, by studying their relationships with market value and Total Factor Productivity. We construct stocks of patents that lie at the two relevant tails of the distribution of the generality index (Trajtenberg et al., 1997; Henderson et al, 1998) to measure general purpose and focused invention at the firm level. In line with expectations, there is a market value premium to focused invention, and a productivity premium to general purpose invention. Estimates for the value of focus indicate that moving a single patent from the upper tail of the generality distribution to the lower tail would increase market value by .24×q million 1992 dollars on average, where q is Tobin’s q. The firm with the average general patent stock would gain 6.7×q million in market value if all its patents at the highest quartile of the generality distribution were moved to the lowest. In terms of the value of general purposeness, moving all its focused patents to the general category increases Total Factor Productivity by 2.3% to 2.8%, and five-year productivity growth by 3.9% to 5.2%, for the average firm. A potential implication is that corporate basic research is associated with significant long-term benefits in terms of productivity growth.Book Part Eu as a Good (enough) Governance Exporter in Kosovo? Local Views on the Aborted Kosovo E Re Power Plant Project(Springer, 2022) Buhari Gülmez, Didem; Aydın Dikmen, BengüThis study focuses on the EU's perceived role in Kosovo as a good governance exporter through political conditionality. Local debates on the EU's stance towards the recently aborted coal power plant project (Kosovo e Re) reflect a disappointment with the EU's failure to prioritise good governance reforms that have not been implemented sufficiently in Kosovo. The study mainly benefits from interviews conducted in Pristina in 2019 in order to explore various EU, domestic and international factors hindering the EU's capability as a good governance exporter. Following the EU's limited transformative agency in contested states, it concludes that the EU is perceived by local actors in Kosovo as a "good enough governance" exporter that favours stability in the region and transatlantic partnership at the expense of good governance reforms. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.Book Part Citation - Scopus: 1Field Experiments in Bargaining(Springer, 2022) Dindaroğlu, Burak; Ertaç, SedaUnderstanding price formation and surplus division in bargaining contexts has long been of interest to economists. Laboratory experiments contribute to our understanding of bargaining by inducing valuations and costs, which are usually unobserved in natural negotiation settings, and allow control over the negotiation process. Field experiments, on the other hand, allow economists to study bargaining in more natural contexts with higher external validity, and can be particularly useful when bargaining behavior draws on context-specific characteristics and experiences that may be stripped in lab settings or involves biases that would not surface under observability. In this chapter, we provide an overview of field experiments studying bargaining behavior and outcomes in a variety of settings, from bargaining for auto rickshaw to markets for livestock. We offer a methodological discussion, position field experiments in bargaining in the tradition of field experiments in economics at large, and highlight difficulties in the design and implementation of fieldwork for such environments. We also discuss potential areas and issues where future field experiments are of special importance for understanding price formation in bargaining. © The Editor(s) (if applicable) and The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022.Book Part Citation - Scopus: 1Destined for Coal?: a "hierarchy of Harms" and the Prospects of Renewable Energy in Kosovo(Springer, 2022) Aydın Dikmen, Bengü; Buhari Gülmez, DidemRelying on interviews conducted in the summer of 2019 with parliamentary advisors, civil society activists, public officials and the EU, OSCE, and UNDP missions in Kosovo, this study provides an overview of the debates about the building of the new coal power plant by a US-led (UK-based) Company ContourGlobal. It discusses how different actors in Kosovo state and society approach the renewable energy question. An important obstacle against Kosovo's transition to renewable energy derives from the absence of consensus about the main threats and goals facing Kosovo. In this context, rationalist and constructivist stances imply different "hierarchies of harms". © The Author(s), under exclusive license to Springer Nature Switzerland AG 2022. All rights reserved.Article Citation - WoS: 5Citation - Scopus: 7Search for Wγ Resonances in Proton-Proton Collisions at S=13 TeV Using Hadronic Decays of Lorentz-Boosted W Bosons(Elsevier B.V., 2022) Sirunyan, A.M.; Tumasyan, A.; Adam, W.; Bergauer, T.; Dragicevic, M.; Erö, J.; Alves, G.A.A search for Wγ resonances in the mass range between 0.7 and 6.0 TeV is presented. The W boson is reconstructed via its hadronic decays, with the final-state products forming a single large-radius jet, owing to a high Lorentz boost of the W boson. The search is based on proton-proton collision data at s=13 TeV, corresponding to an integrated luminosity of 137 fb−1, collected with the CMS detector at the LHC in 2016–2018. The Wγ mass spectrum is parameterized with a smoothly falling background function and examined for the presence of resonance-like signals. No significant excess above the predicted background is observed. Model-specific upper limits at 95% confidence level on the product of the cross section and branching fraction to the Wγ channel are set. Limits for narrow resonances and for resonances with an intrinsic width equal to 5% of their mass, for spin-0 and spin-1 hypotheses, range between 0.17 fb at 6.0 TeV and 55 fb at 0.7 TeV. These are the most restrictive limits to date on the existence of such resonances over a large range of probed masses. In specific heavy scalar (vector) triplet benchmark models, narrow resonances with masses between 0.75 (1.15) and 1.40 (1.36) TeV are excluded for a range of model parameters. Model-independent limits on the product of the cross section, signal acceptance, and branching fraction to the Wγ channel are set for minimum Wγ mass thresholds between 1.5 and 8.0 TeV. © 2022 The Author(s)Article Citation - WoS: 15Citation - Scopus: 19Study of J/Ψ Meson Production Inside Jets in pp Collisions at S=8 TeV(Elsevier B.V., 2020) Sirunyan, A.M.; Tumasyan, A.; Adam, W.; Ambrogi, F.; Bergauer, T.; Brandstetter, J.; Hensel, C.A study of the production of prompt J/ψ mesons contained in jets in proton-proton collisions at s=8TeV is presented. The analysis is based on data corresponding to an integrated luminosity of 19.1 fb−1 collected with the CMS detector at the LHC. For events with at least one observed jet, the angular separation between the J/ψ meson and the jet is used to test whether the J/ψ meson is part of the jet. The analysis shows that most prompt J/ψ mesons having energy above 15 GeV and rapidity |y|<1 are contained in jets with pseudorapidity |η<inf>jet</inf>|<1. The differential distributions of the probability to have a J/ψ meson contained in a jet as a function of jet energy for a fixed J/ψ energy fraction are compared to a theoretical model using the fragmenting jet function approach. The data agree best with fragmenting jet function calculations that use a long-distance matrix element parameter set in which prompt J/ψ mesons are predicted to be unpolarized. This technique demonstrates a new way to test predictions for prompt J/ψ production using nonrelativistic quantum chromodynamics. © 2020 Elsevier B.V.Article International Investors, Volatility, and Herd Behavior: Borsa İstanbul, 2001-2016(2020) Akçaalan, Ezgi; Dindaroğlu, Burak; Binatlı, Ayla OğuşWe study herding in Borsa Istanbul between 2001 and 2016, focusing on the effects of international investors and market volatility. Herding explains 31% of total variability in the cross sectional standard deviation of beta values, controlling for market fundamentals. We perform time-series analysis of a herding index and find that herding increases following increased trading by international investors, but falls with overall trading volume on the market. Herding rises in response to increased volatility, rather than leading to it, against previous arguments. Investors do not herd during economic crises, but following important events that raise political tension in the country.Article Citation - WoS: 26Citation - Scopus: 27Measurement of the Azimuthal Anisotropy of [Formula Presented] and [Formula Presented] Mesons in PbPb Collisions at S NN =5.02 TeV(Elsevier B.V., 2021) Sirunyan, A.M.; Tumasyan, A.; Adam, W.; Ambrogi, F.; Bergauer, T.; Dragicevic, M.; De Jesus Damiao, D.The second-order Fourier coefficients (v<inf>2</inf>) characterizing the azimuthal distributions of [Formula presented] and [Formula presented] mesons produced in PbPb collisions at s<inf> <inf>NN</inf> </inf>=5.02TeV are studied. The [Formula presented] mesons are reconstructed in their dimuon decay channel, as measured by the CMS detector. The collected data set corresponds to an integrated luminosity of 1.7nb−1. The scalar product method is used to extract the v<inf>2</inf> coefficients of the azimuthal distributions. Results are reported for the rapidity range |y|<2.4, in the transverse momentum interval 0<p<inf>T</inf><50GeV/c, and in three centrality ranges of 10–30%, 30–50% and 50–90%. In contrast to the J/ψ mesons, the measured v<inf>2</inf> values for the [Formula presented] mesons are found to be consistent with zero. © 2021 The Author(s)Article Citation - WoS: 205Citation - Scopus: 159Search for Resonances and Quantum Black Holes Using Dijet Mass Spectra in Proton-Proton Collisions at S =8tev(American Physical Society, 2015) Khachatryan, V.; Sirunyan, A.M.; Tumasyan, A.; Adam, W.; Bergauer, T.; Dragicevic, M.; Hegeman, J.A search for resonances and quantum black holes is performed using the dijet mass spectra measured in proton-proton collisions at s=8TeV with the CMS detector at the LHC. The data set corresponds to an integrated luminosity of 19.7fb-1. In a search for narrow resonances that couple to quark-quark, quark-gluon, or gluon-gluon pairs, model-independent upper limits, at 95% confidence level, are obtained on the production cross section of resonances, with masses above 1.2 TeV. When interpreted in the context of specific models the limits exclude string resonances with masses below 5.0 TeV; excited quarks below 3.5 TeV; scalar diquarks below 4.7 TeV; W′ bosons below 1.9 TeV or between 2.0 and 2.2 TeV; Z′ bosons below 1.7 TeV; and Randall-Sundrum gravitons below 1.6 TeV. A separate search is conducted for narrow resonances that decay to final states including b quarks. The first exclusion limit is set for excited b quarks, with a lower mass limit between 1.2 and 1.6 TeV depending on their decay properties. Searches are also carried out for wide resonances, assuming for the first time width-to-mass ratios up to 30%, and for quantum black holes with a range of model parameters. The wide resonance search excludes axigluons and colorons with mass below 3.6 TeV, and color-octet scalars with mass below 2.5 TeV. Lower bounds between 5.0 and 6.3 TeV are set on the masses of quantum black holes. © 2015 CERN, for the CMS Collaboration.
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