Materials Science and Engineering / Malzeme Bilimi ve Mühendisliği
Permanent URI for this collectionhttps://hdl.handle.net/11147/4719
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Article Citation - WoS: 1Citation - Scopus: 1Bioavailability Assessment of the Novel Gsh-Functionalized Feb Nanoparticles Via Oxidative Stress and Trace Element Metabolism in Vitro: Promising Tools for Biomedical Applications(Springer, 2024) Aydemir, Duygu; Aribuga, Dilara; Hashemkhani, Mahshid; Acar, Havva Yagci; Çağıran, Özge Balcı; Ulusu, Nuriye NurayIron-based magnetic nanoparticles (NPs) have attracted significant attention in biomedical research, particularly for applications such as cancer detection and therapy, targeted drug delivery, magnetic resonance imaging (MRI), and hyperthermia. This study focuses on the synthesis and glutathione (GSH) functionalization of iron boride (FeB) nanoparticles (NPs) for prospective biomedical use. The GSH-functionalized FeB NPs (FeB@GSH) demonstrated ferromagnetic behavior, with a saturation magnetization (Ms) of 45.8 emu/g and low coercivity (Hc = 1000 Oe), indicating desirable magnetic properties for biomedical applications. Transmission electron microscopy (TEM) analysis of the FeB@GSH revealed well-dispersed nanoparticles with diameters smaller than 30 nm. Comprehensive nanotoxicity and biocompatibility assessments were performed using various healthy and cancer cell lines, including 293 T, HeLa, 3T3, MCF7, HCT116, and CFPAC-1. Cytotoxicity assays were conducted on FeB@GSH-treated cells over a dose range of 0-300 mu g/mL during 24-h incubations. Results indicated no significant differences in cell viability between treated and untreated control groups, confirming the biocompatibility of FeB@GSH. Further nanotoxicity evaluations were carried out on 3T3, 293 T, and CFPAC-1 cell lines, focusing on oxidative stress markers and cellular metabolism by measuring antioxidant enzyme activity. Additionally, ion release and mineral metabolism were assessed using inductively coupled plasma mass spectrometry (ICP-MS), revealing no notable variations between the treated and control groups. These findings suggest that FeB@GSH NPs exhibit excellent biocompatibility, making them promising candidates for diverse biomedical applications, including medical imaging, drug delivery systems, and therapeutic interventions.Article Citation - WoS: 5Citation - Scopus: 7Characterization and Separation Behavior of Multi-Layers in Aluminum-Rich Waste Pharmaceutical Blisters(Springer, 2023) Çapkın, İrem Yaren; Gökelma, MertolAl-rich waste pharmaceutical blisters (WPBs) have a multi-layer structure that contains aluminum and polymer-based fractions. Although the aluminum mass in WPBs is less than typical aluminum packaging products such as beverage cans, establishing a feasible recycling procedure is possible by separating the fractions to recover both metal and plastic. Hydrometallurgical methods are mostly preferred for the separation of aluminum and plastic in multi-layered structures. This work reports the characterization of Al-rich WPBs and the separation behavior of aluminum and plastic layers. The effects of hydrochloric acid, acetic acid, formic acid, sulfuric acid, ethanol, acetone, and organic solvent (benzene–ethanol–water) on the separation behavior of layers were studied at different temperatures. Furthermore, the recycling yield of the aluminum fraction was experimentally assessed. © 2023, The Minerals, Metals & Materials Society.Article Citation - WoS: 1Citation - Scopus: 2An Investigation on Inclusions Forming During Remelting of Aluminum and Magnesium Scraps Under a Salt Flux(Springer, 2023) Çapkın, İrem Yaren; Gökelma, MertolDue to increasing environmental and economic concerns, the recycling of metals has been increasing in the last decades. Aluminum saves up to 95% of energy when recycled, and magnesium is one of the most common alloying elements in aluminum alloys, contributing to oxidation behavior. Both aluminum and magnesium have a high oxidation tendency during remelting, which raises the necessity for salt flux usage. Salt fluxes remove oxides and other surface contaminants from the target metal. Salt fluxes allow molten metal pieces to coagulate and form the molten bath. Furthermore, it prevents further oxidation of the metal. The presence of fluorides increases the metal yield by promoting coalescence. Although metals and salts are frequently interacting in such processes, there is still a lack of knowledge of the final and intermediate products of the interaction reactions. This study aims to contribute to the literature by investigating the interaction of aluminum and magnesium scraps with salt flux. As a result of the experiments, AlF3, MgF2, Al2O3, MgO, and MgAl2O4 were observed as the main phases in the aluminum and magnesium scraps dross. The presence of CaF2 in the salt flux, which is insoluble in water, was also observed in the analysis results. In addition, fluorine-containing compounds were observed as a result of chemical interactions among the F-, K-, and oxide layers.