Phd Degree / Doktora

Permanent URI for this collectionhttps://hdl.handle.net/11147/2869

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COAR Access Rights: search.filters.coarAccessRights.embargoed accessDepartment: search.filters.department.Thesis (Doctoral)--İzmir Institute of Technology, Bioengineering

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  • Doctoral Thesis
    Development of a Telemedicine Platform for Remote Monitoring of Patients
    (01. Izmir Institute of Technology, 2023) Tarım, Ergün Alperay; Tekin, Hüseyin Cumhur; Mevsim, Vildan
    Telemedicine supports patients and healthcare professionals to provide remote medical services and to ensure that medical operations, services, and applications. Telemedicine provides mobile health services, doctor-patient communication, relationship and consultation, medical clinic, and operation service for the diagnosis, monitoring, treatment, and rehabilitation by remote health services. In this thesis, telemedicine-based applications and integrated devices are developed to assist in the diagnosis, monitoring, and treatment processes of specific diseases. In this regard, a WebRTC-based telemedicine application has been developed to ensure the transfer of health data and doctor-patient communication for monitoring diseases. The developed telemedicine application performance of providing doctor-patient communication and its effect on the management of chronic heart failure disease were examined. Thereupon, medical diagnosis and wearable devices have been developed that can be integrated into the telemedicine application that has been proven for disease monitoring. As part of this study, vital health data, biomarkers, and pathogen analysis were performed by developed devices to diagnose and monitor three chronic diseases, namely sleep apnea, chronic kidney disease, and COVID-19. First, a wearable device platform has been developed that can analyze breathing patterns via diaphragm acceleration and breath temperature and diagnose and monitor sleep apnea. Afterward, electromechanical LOC platforms used for colorimetric determination of serum creatinine levels for the diagnosis of chronic kidney disease by two methods were characterized and presented in detail. Finally, a real-time LAMP-based electromechanical device used to detect SARS-CoV-2 viral RNA has been produced, and a colorimetric rapid test system has been developed and tested for COVID-19 diagnosis. In this way, devices and systems integrated into the telemedicine platform have been developed for use in different diseases and medical applications. With these developed platforms, disease diagnosis, treatment and rehabilitation, remote monitoring and patient management are provided with inexpensive, portable, user-friendly, easy-to-use solutions without the need for professional service providers.
  • Doctoral Thesis
    Development and Characterization of Novel Bioink by Using Decellularized Extracellular Matrix for Bone Tissue Engineering Applications
    (01. Izmir Institute of Technology, 2023) Kara Özenler, Aylin; Tıhmınlıoğlu, Funda; Havıtçıoğlu, Hasan
    Bone tissue engineering has focused on the development of functional scaffolds that can organize bone regeneration with appropriate structures and properties. Three-dimensional (3D) printing technology enables the development of personalized scaffolds. In addition, biological scaffolds obtained by decellularization have various advantages for developing natural-based scaffolds. The development of printable, patient-specific bioinks derived from decellularized extracellular matrix could provide 3D fabrication of tissues and organs with high potential to mimic native tissues. The presented thesis study demonstrates the development of various bioink compositions for bone tissue engineering applications. In this regard, bone tissues were decellularized with a novel method and then characterized in order to verify the removal of whole cellular components for eliminating immunological reactions. After the pulverization of tissues, decellularized bone (DB) particles were used as an additive within various ink combinations (alginate-, gelatin- and alginate-gelatin-based). Thus, various bioink formulations were developed containing DB particles, biopolymers and mesenchymal stem cells (MSC). All prepared bioinks were bioprinted, then the viability, proliferation and differentiation capacity of the cells inside the structures as well as the physical, rheological, and printability properties of the inks were assessed. The results revealed that all bioink combinations were suitable for bioprinting and the addition of DB particles improved cell proliferation and osteogenic differentiation in all bioink formulations. Alginate-based bioinks exhibited the greatest printability and shape fidelity, gelatin-based bioinks showed the highest cell proliferation and attachment, also, gelatin incorporation into alginate-based bioinks improved the biological activity of cells. In conclusion, cytocompatible, functional composite bioinks developed in this thesis study are of value for bone tissue engineering research in future to explore their functions in the living system and show complete bone regeneration while maintaining their stability for a long time.