Electrical - Electronic Engineering / Elektrik - Elektronik Mühendisliği
Permanent URI for this collectionhttps://hdl.handle.net/11147/11
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Conference Object Farklı Kontrastlı Medi̇kal Görüntülerde Elasti̇k Hi̇zalama İ̇çi̇n Ni̇rengi̇ Noktalarının Beli̇rlenmesi̇ ve Sınanması(IEEE, 2011) Karaçalı, Bilge; Karaçalı, Bilge; 03.05. Department of Electrical and Electronics Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyIn this study, automatic identification of landmarks was carried out on real double-echo PD/T2 Magnetic Resonance images for use in multi-modality deformable image registration algorithms. To this end, the corner points of the PD-weighted Magnetic Resonance image selected as the reference image were identified at varying fields of view and used as landmark candidates after eliminating the repeated points and those at close proximity. Next, the matching performances of these candidates were determined by invoking a localization algorithm that optimizes information theoretic point similarity measures derived earlier after random initialization at varying distances and directions. In consideration to the best performing point similarity measures and neighborhood radii at landmarks providing successful localization, the mutual information-based point similarity measure evaluated over large neighborhoods was preferred at a conspicuously higher rate than the other alternatives. © 2011 IEEE.Article Citation - WoS: 19Citation - Scopus: 25Taste dysfunction in multiple sclerosis(D. Steinkopff-Verlag, 2016) Doty, Richard L.; Karaçalı, Bilge; Pham, Dzung L.; Cuzzocreo, Jennifer L.; Udupa, Jayaram K.; Karaçalı, Bilge; Beals, Evan; Fabius, Laura; Leon-Sarmiento, Fidias E.; Moonis, Gul; Kim, Taehoon; Mihama, Toru; Geckle, Rena J.; Yousem, David M.; 03.05. Department of Electrical and Electronics Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyEmpirical studies of taste function in multiple sclerosis (MS) are rare. Moreover, a detailed assessment of whether quantitative measures of taste function correlate with the punctate and patchy myelin-related lesions found throughout the CNS of MS patients has not been made. We administered a 96-trial test of sweet (sucrose), sour (citric acid), bitter (caffeine) and salty (NaCl) taste perception to the left and right anterior (CN VII) and posterior (CN IX) tongue regions of 73 MS patients and 73 matched controls. The number and volume of lesions were assessed using quantitative MRI in 52 brain regions of 63 of the MS patients. Taste identification scores were significantly lower in the MS patients for sucrose (p = 0.0002), citric acid (p = 0.0001), caffeine (p = 0.0372) and NaCl (p = 0.0004) and were present in both anterior and posterior tongue regions. The percent of MS patients with identification scores falling below the 5th percentile of controls was 15.07 % for caffeine, 21.9 % for citric acid, 24.66 % for sucrose, and 31.50 % for NaCl. Such scores were inversely correlated with lesion volumes in the temporal, medial frontal, and superior frontal lobes, and with the number of lesions in the left and right superior frontal lobes, right anterior cingulate gyrus, and left parietal operculum. Regardless of the subject group, women outperformed men on the taste measures. These findings indicate that a sizable number of MS patients exhibit taste deficits that are associated with MS-related lesions throughout the brain.