Computer Engineering / Bilgisayar Mühendisliği
Permanent URI for this collectionhttps://hdl.handle.net/11147/10
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Article Citation - WoS: 4Citation - Scopus: 4Integrative Biological Network Analysis To Identify Shared Genes in Metabolic Disorders(Institute of Electrical and Electronics Engineers, 2022) Tenekeci, Samet; Işık, ZerrinIdentification of common molecular mechanisms in interrelated diseases is essential for better prognoses and targeted therapies. However, complexity of metabolic pathways makes it difficult to discover common disease genes underlying metabolic disorders; and it requires more sophisticated bioinformatics models that combine different types of biological data and computational methods. Accordingly, we built an integrative network analysis model to identify shared disease genes in metabolic syndrome (MS), type 2 diabetes (T2D), and coronary artery disease (CAD). We constructed weighted gene co-expression networks by combining gene expression, protein-protein interaction, and gene ontology data from multiple sources. For 90 different configurations of disease networks, we detected the significant modules by using MCL, SPICi, and Linkcomm graph clustering algorithms. We also performed a comparative evaluation on disease modules to determine the best method providing the highest biological validity. By overlapping the disease modules, we identified 22 shared genes for MS-CAD and T2D-CAD. Moreover, 19 out of these genes were directly or indirectly associated with relevant diseases in the previous medical studies. This study does not only demonstrate the performance of different biological data sources and computational methods in disease-gene discovery, but also offers potential insights into common genetic mechanisms of the metabolic disorders.Conference Object Citation - WoS: 4Citation - Scopus: 12Event Oriented Vs Object Oriented Analysis for Microservice Architecture: an Exploratory Case Study(Institute of Electrical and Electronics Engineers, 2021) Ünlü, Hüseyin; Tenekeci, Samet; Yıldız, Ali; Demirörs, OnurThe rapidly developing internet infrastructure together with the advances in software technology has enabled the development of cloud-based modern web applications that are much more responsive, flexible, and reliable compared to traditional monolithic applications. Such modern applications require new software design paradigms and architectures. Microservice-based architecture (MSbA), which aims to create small, isolated, loosely-coupled applications that work in cohesion, becoming widespread as one of these approaches. MSbA allows the developed applications to be deployed and maintained separately, as well as scaled on demand. However, there is no de facto method for the analysis and design of systems for these architectures. In this paper, we compared the usefulness of the object-oriented (OO) and event-oriented (EO) approaches for analyzing and designing MS-based systems. More specifically, we performed an exploratory case study to analyze, design, and implement a software application dealing with the 'application and evaluation process of graduate students at IzTech'. This paper discusses the results of this case study. We observe that the EO approaches have significant advantages with respect to the OO approaches.