Computer Engineering / Bilgisayar Mühendisliği
Permanent URI for this collectionhttps://hdl.handle.net/11147/10
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Article Citation - WoS: 1Citation - Scopus: 1How Software Practitioners Perceive Work-Related Barriers and Benefits Based on Their Educational Backgrounds: Insights From a Survey Study(IEEE, 2023) Ünlü, Hüseyin; Yürüm, Ozan Raşit; Özcan Top, Özden; Demirörs, OnurSurvey results show that software practitioners from nonsoftware-related backgrounds face more barriers, have fewer benefits, and feel less satisfied in their work life. However, these differences reduce with more than 10 years of experience and involvement in software-related graduate programs, certificates, and mentorship.Article Citation - WoS: 3Citation - Scopus: 6An Exploratory Case Study Using Events as a Software Size Measure(Springer, 2023) Hacaloğlu, Tuna; Demirörs, OnurSoftware Size Measurement is a critical task in Software Development Life Cycle (SDLC). It is the primary input for effort estimation models and an important measure for project control and process improvement. There exist various size measurement methods whose successes have already been proven for traditional software architectures and application domains. Being one of them, functional size measurement (FSM) attracts specific attention due to its applicability at the early phases of SDLC. Although FSM methods were successful on the data-base centric, transaction oriented stand-alone applications, in contemporary software development projects, Agile methods are highly used, and a centralized database and a relational approach are not used as before while the requirements suffer from a lack of detail. Today's software is frequently service based, highly distributed, message-driven, scalable and has unprecedented levels of availability. In the new era, event-driven architectures are appearing as one of the emerging approaches where the 'event' concept largely replaces the 'data' concept. Considering the important place of events in contemporary architectures, we focused on approaching the software size measurement problem from the event-driven perspective. This situation guided us to explore how useful event as a size measure in comparison to data-movement based methods. The findings of our study indicates that events can be promising for measurement and should be investigated further in detail to be formalized for creating a measurement model thereby providing a replicable approach.Article Citation - WoS: 4Citation - Scopus: 4Integrative Biological Network Analysis To Identify Shared Genes in Metabolic Disorders(Institute of Electrical and Electronics Engineers, 2022) Tenekeci, Samet; Işık, ZerrinIdentification of common molecular mechanisms in interrelated diseases is essential for better prognoses and targeted therapies. However, complexity of metabolic pathways makes it difficult to discover common disease genes underlying metabolic disorders; and it requires more sophisticated bioinformatics models that combine different types of biological data and computational methods. Accordingly, we built an integrative network analysis model to identify shared disease genes in metabolic syndrome (MS), type 2 diabetes (T2D), and coronary artery disease (CAD). We constructed weighted gene co-expression networks by combining gene expression, protein-protein interaction, and gene ontology data from multiple sources. For 90 different configurations of disease networks, we detected the significant modules by using MCL, SPICi, and Linkcomm graph clustering algorithms. We also performed a comparative evaluation on disease modules to determine the best method providing the highest biological validity. By overlapping the disease modules, we identified 22 shared genes for MS-CAD and T2D-CAD. Moreover, 19 out of these genes were directly or indirectly associated with relevant diseases in the previous medical studies. This study does not only demonstrate the performance of different biological data sources and computational methods in disease-gene discovery, but also offers potential insights into common genetic mechanisms of the metabolic disorders.