Sürdürülebilir Yeşil Kampüs Koleksiyonu / Sustainable Green Campus Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7755
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Conference Object Citation - WoS: 2Citation - Scopus: 2Arsenic in Groundwater in Western Anatolia, Turkey: a Review(University of Silesia Press, 2010) Gündüz, Orhan; Baba, Alper; Elpit, HandanOccurrence of arsenic (As) in groundwater has been a major problem worldwide for the last hundred years. Considering its toxic effects on human health, the presence of elevated levels of arsenic in groundwater resources used in drinking water supply has been an active research field throughout the world (Van Halem et al., 2009). In this regard, case studies from Bangla-desh, India, Nepal, El Salvador, Ecuador, Honduras, Mexico, Chile, China, Canada, Argentina, Peru, Taiwan, United States, Bolivia and Turkey have been documented with regards to the detection of natural levels in groundwater, the occurrence and distribution mechanisms, the human health effects and the in-situ and ex-situ treatment techniques (Jean et al., 2010). In many of these locations, arsenic is naturally found in the subsurface strata within volcanic and sedimentary formations as well as in areas of geothermal systems related to tectonic activity. Western Anatolia in Turkey is one such area of complex geology with active tectonics and high geothermal potential. This natural setting serves as a suitable environment for the presence of high levels of arsenic in subsurface waters. Based on these fundamentals, this study presents a general overview of arsenic presence in western Anatolia.Conference Object Occurrence of Arsenic and Related Microbial Signature of Hydrothermal Systems in Western Turkey(Taylor & Francis, 2012) Chen, Chienyen; Maity, Jyoti Prakash; Bundschuh, Jochen; Bhattacharya, Prosun; Baba, Alper; Gündüz, OrhanThe naturally occurring aqueous Arsenic (As) and other toxic elements are found around the world. The present study concentrates on arsenic concentrations, speciation and related microbial diversity in a hydrothermal system in Western Turkey. The surface temperatures of hot springs reach up to 90°C and deep well (reservoir) temperatures vary in the range of 40 to 230°C. The elements such as As, B, Br, Ba, Cr, Fe, Mn, V and Zn are found in high concentration in hydrothermal waters. Hydrogeochemically, Seferihisar hot spring exhibited a Na-Cl water type. On the other hand, Karahayit, Pamukkale, Emirfaki, Alaşehir and Sart exhibit a Ca-HCO 3 water type and Çitgöl exhibited a Na-HCO 3-SO 4 water type. The arsenic (As) concentrations in geothermal waters of Western Anatolia have been detected to range from 0.03 mg/L to 1.5 mg/L, including Buharkent (İnalti) (1.50 ± 0.005 mg/L), Kizildere (1.13 ± 0.005 mg/L), Eynal (0.71 ± 0.005 mg/L) and Sarayköy (0.06 ± 0.004 mg/L). Arsenic (III) is the dominant species in geothermal water of Western Anatolia. The 16S rRNA gene sequences of bacterial diversity show that the thermophilic, sulfur/thiosulfate-oxidizing bacterium (Thiobacter subterraneus) is present in Kula geothermal water and mesophilic sulfur- and thiosulfate-oxidizing Sulfurovum lithotrophicum bacterium occurs in Sarayköy geothermal spring. Also, Bacillus fumarioli, (a thermophilic, aerobic endospore forming bacterium growing on (NH 4) 2 SO 4, MgSO 4 and MnSO 4 at 50-55°C), Schlegelella thermodepolymerans and Methylocaldum szegediense are rich in geothermal water.Conference Object Citation - Scopus: 4High Arsenic Levels in Groundwater Resources of Gediz Graben, Western Turkey(CRC Press, 2016) Baba, Alper; Gündüz, Orhan; Şimşek, Celalettin; Elçi, Alper; Sözbilir, Hasan; Murathan, AlimGediz Graben situated in western Turkey is an area containing extensional structures with active tectonics and geothermal systems that serves as a suitable environment for the presence of high levels of arsenic (As) in groundwater. The results of a comprehensive monitoring program in the basin revealed that the maximum As concentration detected during the monitoring program was 3086 ppb and the average value was calculated to be 23.63 ppb. In addition, As levels in 28% of the water samples were above the 10 ppb limit value making them unsuitable for drinking water supply. These high As concentrations in the basin was mostly associated with long detention times of water in altered rocks located along detachment faults, strong water–rock interaction processes in the alteration zones and anthropogenic influences made within the geothermal fluid reservoir. © 2016 Taylor & Francis Group, London.Master Thesis Elucidation of Molecular Mechanisms Conferring Arsenic Tolerance To Yeast Cells(Izmir Institute of Technology, 2016) Işık, Esin; Karakaya, Hüseyin ÇağlarArsenic is a highly toxic metalloid available in the environment mainly as arsenite or arsenate. These compounds’ interference with many molecular mechanisms results in several diseases including cancer. Conversely, arsenic is used in therapeutic approaches, however, they are associated with drug resistance. Although some tolerance and toxicity mechanisms of arsenicals in yeast have been enlightened by previous studies, complete understanding, which is important for development of protection and therapy strategies, has not yet been achieved. Comprehensive genome-wide screening is a promising approach for the elucidation of novel genes involved in arsenic-associated mechanisms. The aim in this study was to screen a yeast genome library to characterize novel genes whose overexpression confers resistance to toxic concentrations of arsenate or arsenite in Saccharomyces cerevisiae. The plasmids from the colonies confirmed to be highly-resistant against arsenicals were sequenced to determine the genomic regions and seven genes were selected to clone into expression vectors. The overexpression of Pho86p and Vba3p provided yeast cells with the highest arsenate and arsenite resistance, respectively. Arsenate is a phosphate analogue and taken up by phosphate transporters. Pho86p is an ER-resident protein regulating ER-exit of the phosphate transporter. Therefore, it is reasonable that overexpression of Pho86p provides arsenate resistance. Vacuolar sequestration is a common route for the removal of toxic compounds from the cytosol and Vba3p is a vacuole-located transporter of basic amino acids with a likely role in arsenite resistance. Consequently, the screen in the current study revealed two genes with promising roles for tolerance mechanisms against arsenicals.