Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik

Permanent URI for this collectionhttps://hdl.handle.net/11147/9

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Institution Author: search.filters.institutionAuthor.Esmer, Işıl

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  • Article
    Citation - WoS: 2
    Citation - Scopus: 4
    Protective Effects of Polyamines Against Uv-A and Uv-B Illumination in Physcia Semipinnata Thalli
    (Institute of Botany and Botanical Garden Jevremovac, 2017) Esmer, Işıl; Tüney, İnci; Ünal Özakça, Dilek; Sukatar, Atakan
    The damage to DNA induced by UV-A and UV-B and protective effects of the polyamines putrescine (put), spermidine (spd) and spermine (spm) were investigated on the lichen Physcia semipinnata in the present study. Our results suggest that significant alterations of the photosynthetic quantum yield ratio occurred in response to increased UV-A and UV-B exposure time. The photosynthetic quantum yield ratio gradually decreased in P. semipinnata following exposure to UV-A and UV-B. Physcia semipinnata thalli which were treated with a polyamine in a concentration of 1 mM were not affected by UV-A exposure for 72 h. In the case of UV-B treatment, the protective polyamine dosage was 0.25 mM. We also used the random amplified polymorphic DNA (RAPD) technique to detect DNA damage. The main changes observed in the RAPD profiles, which were obtained using 12 RAPD primers, were the appearance or disappearance of different bands and variation of their intensities. The use of at least three different primers allowed detection of specific band patterns in both UV-A- and UV-B-exposed samples treated with polyamines as compared to untreated ones.
  • Article
    Citation - WoS: 7
    Citation - Scopus: 7
    The Roles of Thiol Oxidoreductases in Yeast Replicative Aging
    (Elsevier Ltd., 2010) Hacıoğlu, Elise; Esmer, Işıl; Fomenko, Dmitri E.; Gladyshev, Vadim N.; Koç, Ahmet
    Thiol-based redox reactions are involved in the regulation of a variety of biological functions, such as protection against oxidative stress, signal transduction and protein folding. Some proteins involved in redox regulation have been shown to modulate life span in organisms from yeast to mammals. To assess the role of thiol oxidoreductases in aging on a genome-wide scale, we analyzed the replicative life span of yeast cells lacking known and candidate thiol oxidoreductases. The data suggest the role of several pathways in controlling yeast replicative life span, including thioredoxin reduction, protein folding and degradation, peroxide reduction, PIP3 signaling, and ATP synthesis. © 2010 Elsevier Ireland Ltd.