Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik

Permanent URI for this collectionhttps://hdl.handle.net/11147/9

Browse

Filters

2014 - 20172

Settings

Publication Index: search.filters.publicationIndex.ScopusSubject: search.filters.subject.Invadopodia

Search Results

Now showing 1 - 2 of 2
  • Article
    Citation - WoS: 1
    Cellular Distribution of Invadopodia Is Regulated by Nanometer Scale Surface Protein Patterns
    (Elsevier Ltd., 2017) Batı Ayaz, Gizem; Can, Ali; Pesen Okvur, Devrim
    Invadopodia are proteolytic structures formed by cancer cells. It is not known whether their cellular distribution can be regulated by the organization of the extracellular matrix or the organization of the golgi complex or whether they have an adhesion requirement. Here, we used electron beam lithography to fabricate fibronectin (FN) nanodots with isotropic and gradient micrometer scale spacings on K-casein and laminin backgrounds. Investigating cancer cells cultured on protein nanopatterns, we showed that (i) presence of FN nanodots on a K-casein background decreased percent of cells with neutral invadopodia polarization compared to FN control surfaces; (ii) presence of a gradient of FN nanodots on a K-casein background increased percent of cells with negative invadopodia polarization compared to FN control surfaces; (iii) polarization of the golgi complex was similar to that of invadopodia in agreement with a spatial link; (iv) local adhesion did not necessarily appear to be a prerequisite for invadopodia formation.
  • Article
    Citation - WoS: 5
    Citation - Scopus: 5
    Invadopodia: Proteolytic Feet of Cancer Cells
    (TUBITAK, 2014) Batı, Gizem; Pesen Okvur, Devrim
    The leading cause of death in cancer patients is metastasis. Invasion is an integral part of metastasis and is carried out by proteolytic structures called invadopodia at the cellular level. In this introductory review, we start by evaluating the definition of invadopodia. While presenting the upstream signaling events involved, we integrate current models on invadopodia. In addition, we discuss the significance of invadopodia in 2D and 3D and in vivo. We finally point out technical challenges and conclude with open questions in the field. © TÜBİTAK.