Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Permanent URI for this collectionhttps://hdl.handle.net/11147/9
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Article Citation - WoS: 27Citation - Scopus: 27Epithelial-Myeloid Exchange of Mhc Class Ii Constrains Immunity and Microbiota Composition(Elsevier, 2021) Stephens, W. Zac; Kubinak, Jason L.; Ghazaryan, Arevik; Bauer, Kaylyn M.; Buhrke, Kate; Round, June L.; Ekiz, Hüseyin AtakanIntestinal epithelial cells (IECs) have long been understood to express high levels of major histocompatibility complex class II (MHC class II) molecules but are not considered canonical antigen-presenting cells, and the impact of IEC-MHC class II signaling on gut homeostasis remains enigmatic. As IECs serve as the primary barrier between underlying host immune cells, we reasoned that IEC-intrinsic antigen presentation may play a role in responses toward the microbiota. Mice with an IEC-intrinsic deletion of MHC class II (IECΔMHC class II) are healthy but have fewer microbial-bound IgA, regulatory T cells (Tregs), and immune repertoire selection. This was associated with increased interindividual microbiota variation and altered proportions of two taxa in the ileum where MHC class II on IECs is highest. Intestinal mononuclear phagocytes (MNPs) have similar MHC class II transcription but less surface MHC class II and are capable of acquiring MHC class II from IECs. Thus, epithelial-myeloid interactions mediate development of adaptive responses to microbial antigens within the gastrointestinal tract.Book Part Citation - WoS: 10Citation - Scopus: 16Plant-Microbe Interactions in Phytoremediation(Elsevier Ltd., 2014) Özyiğit, İbrahim İlker; Doğan, İlhanOur atmosphere, water resources and soil are becoming increasingly contaminated with inorganic and organic compounds as a result of anthropogenic-driven inputs, mainly from industry, mining, motorized traffic, agriculture, logging and military actions. Alleviation and prevention of environmental pollution can be achieved by utilization of plants and their associated microbes. Recent advances in plant-microbe interaction research revealed that plants are able to shape their rhizosphere microbiome through active secretion of substrates that are known to vary between plant species. Soil-borne microorganisms such as actinobacteria, algae, protozoa and different types of bacteria having different capabilities of functional activities can vary extensively in soils and occur in associations in the rhizosphere of plants. Microbial associations are known to affect mobility and availability of substances to the plant through the release of chelating agents, acidification, phosphate solubilization and redox changes and exudates derived from the plant can help to stimulate the survival and action of these microorganisms. A broad knowledge about the mechanisms in plants for the uptake, translocation, storage, and detoxification of contaminants, and interactions between plants and microorganisms are critical in developing technologies and best management practices for environmental clean-up. A comprehensive understanding of interactions between plants and rhizospheric microorganisms in the rhizosphere and plant-based processes will provide new opportunities to develop more efficient plants and better management practices for removal of contaminants. This chapter reviews plant-microbe interactions in phytoremediation with particular reference to the microbial dynamics in the rhizosphere of plants growing on contaminated soils.