Bioengineering / Biyomühendislik
Permanent URI for this collectionhttps://hdl.handle.net/11147/4529
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Annotation On-Chip 3d Cell Culture Platform for Tumor Modeling and Drug Screening(2022) Yıldırım, Özüm; Arslan Yıldız, AhuConference Object Size-Based Microparticle Seperation Using Negative Magnetophoresis(Chemical and Biological Microsystems Society, 2021) Solmaz Özçelik, Özge; Öksüz, Cemre; Tekin, Hüseyin CumhurWe present a new size-based microparticle separation device using negative magnetophoresis. Microparticles spiked in the paramagnetic medium were filtered with respect to their sizes in a microfluidic channel placed between two magnets. Negative magnetophoresis allows large microparticles to be captured before the magnets, while small microparticles pass through the magnets under a constant flow. With this method, we reached 84.2% capturing efficiency of large microparticles (44 µm diameter) and capturing purity of 80.3% in the presence of small microparticles (17 µm diameter) at 3 µL/min flow rate. The capturing purity could further improve up to 99% by increasing the flow rate.Conference Object Role of Myelin Topography and Alignment on the Activation of Astrocytes(Mary Ann Liebert, Inc, 2017) Gürer, F.; Bulmuş Zareie, Volga; Bulmus Zareire, Esma Volga; Baskerville, K.; Özdemir, T.Myelin sheath is thick layers of neuronal plasma membrane that serves as a capacitor during neuronal signal transmission. Decay in myelin sheath is associated with several neurodegenerative diseases such as multiple sclerosis and Alzheimer disease. Although its primary purpose is to insulate and accelerate the neuronal impulse, very few studies focused on the geometrical aspect of myelination in neuronal function. Here, we developed a versatile platform to study the effect of myelin topography and alignment on the neuronal signal transmission.Conference Object Induction of Secondary Metabolism of Marine Derived Streptomyces Cacaoi(Georg Thieme Verlag, 2019) Gezer, Erkin; Bilgi, Eyüp; Küçüksolak, Melis; Bedir, ErdalMicrobial natural products have an adaptive role as signal molecules or defense tools in ecological interactions. Biosynthesis of these molecules is suppressed in standard laboratory conditions where there are no ecological triggers. Thus, only a portion of the chemical diversity of a microbial strain is discovered by standard fermentation protocols. However, using different fermentation conditions or different approaches such as co-culture, biosynthesis of these suppressed molecules can be triggered, and new natural products can be isolated.