Bioengineering / Biyomühendislik
Permanent URI for this collectionhttps://hdl.handle.net/11147/4529
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Conference Object On-Chip 3d Cell Culture Platform for Tumor Modeling and Drug Screening(Mary Ann Liebert, 2022) Yıldırım, Özüm; Arslan Yıldız, AhuThree-dimensional (3D) cell culture allows cell-cell and cellmatrix interactions and provides more in vivo like models rather than 2D cell culture which cannot fully mimic native tissue. 3D cell culture on microfluidics allows formation of 3D structures that mimic the physiological and chemical microenvironment for cells[1]. These microfluidic platforms also downsize bench-top laboratory to a microchip, require miniaturized reagent, and are convenient for dynamic drug screening[2]. In this study, a microfluidic platform was designed which is housing a PLLCL scaffold fabricated by electrospinning methodology.Conference Object Development of 3d Cardiac Models Via Magnetic Manipulation for Drug Screening Studies(Mary Ann Liebert, 2022) Önbaş, Rabia; Arslan Yıldız, AhuDrug discovery and development process comprise of preclinical and clinical phases that are very intensive, long, and expensive research phases. However, drug candidates can fail in clinical trials. Toxicity is the major reason that leads to about 30% of drug development failures. Recently, the withdrawal rate of drugs from the market was increased to 33.3%from5.1%due to cardiotoxicity. When the drug fails at phase I, the reasons are probably related to 2-dimensional (2D) cell culture studies that do not represent the real tissue physiology; therefore, they provide misdirected data about the efficacy and toxicity of drug.