Bioengineering / Biyomühendislik

Permanent URI for this collectionhttps://hdl.handle.net/11147/4529

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Access type: Metadata onlyInstitution Author: search.filters.institutionAuthor.Üner, Göklem

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  • Conference Object
    A New Semi-Synthetic Sapogenol Derivative Inducing Regulated Necrosis
    (Georg Thieme Verlag, 2019) Üner, Göklem; Ballar Kırmızıbayrak, Petek; Bedir, Erdal
    Since saponin’s antitumor potency is relatively weak, researchers focus on their semi-synthetic modification to obtain structures with higher potencies. With the same motivation, we prepared a cytotoxic sapogenol derivative (AG-08) from cycloastragenol. Our preliminary studies revealed that AG-08 induced primarily necrotic cell death along with autophagic inhibition. Furthermore, immunoblotting experiments demonstrated that AG-08 promoted cleavage of various proteins such as ATGs, p62, and PARP-1.