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Computational Nanotoxicology: a Case Study With Silver and Zinc Nanomaterials
(Elsevier, 2022) Bilgi, Eyüp; Öksel Karakuş, Ceyda
Nanomaterials (NMs) have been the focus of basic and applied research for more than two decades. According to the updated consumer materials inventory, over 1800 commercial NMs have taken their place in the market, 42% of which are in health and wellness category1. The widespread use of NMs in health-related products made not only the human exposure to the (residues of) NMs inevitable but also the long-recognized concerns over their safety a priority. Despite this pressing need, more than 70% of commercially available nano-containing products do not include sufficient information about their physicochemical and/or toxicological characteristics.
Citation - WoS: 19
Citation - Scopus: 21
Bacterial Cellulose Based Facial Mask With Antioxidant Property and High Moisturizing Capacity
(Springer, 2021) Bilgi, Eyüp; Homan Gökçe, Evren; Bayır, Ece; Şendemir, Aylin; Özgen Özer, Kevser; Hames Tuna, Elif Esin
Bacterial cellulose (BC) produced by certain bacteria has the potential to be used in many different areas. Despite its advantageous properties compared to plant cellulose, such as high purity, mechanical strength, nanofiber mesh structure, and high-water holding capacity, its production through a biotechnological process prevents it from competing with plant counterparts in terms of cost-effectiveness. Therefore, studies have focused on the development of culture media with cost-effective BC production methods and the production of high value-added products from BC. In this study, it was aimed to develop a taurine-loaded moisturizing facial mask with antioxidant properties based on BC's high-water retention and chemical retention capacity. BC facial mask samples were characterized by Scanning Electron Microscopy (SEM) imaging, Fourier Transform Infrared (FTIR) Spectroscopy, Differential Scanning Calorimetry (DSC), Liquid Chromatography-Mass spectrometry (LC-MS), microbial and mechanical stability tests, as well as cytotoxicity tests. According to our results, produced facial mask samples did not show any cytotoxic effect on human keratinocyte (HS2) or mouse fibroblast (L-929) cell lines; it has high thermal stability, which makes it suitable for different sterilization techniques including sterilization by heat treatment. Taurine release (over 2 mu g/mL in 5 min) and microbial stability tests (no bacterial growth observed) of packaged products kept at 40 and 25 degrees C for 6 months have shown that the product preserves its characteristics for a long time. In conclusion bacterial cellulose-based facial masks are suitable for use as a facial mask, and they can be used for moisturizing and antioxidant properties by means of taurine.
Citation - WoS: 37
Citation - Scopus: 40
Biomedical Nanomaterials: Applications, Toxicological Concerns, and Regulatory Needs
(Informa Healthcare, 2020) Öksel Karakuş, Ceyda; Bilgi, Eyüp; Winkler, David
Advances in cutting-edge technologies such as nano- and biotechnology have created an opportunity for re-engineering existing materials and generating new nano-scale products that can function beyond the limits of conventional ones. While the step change in the properties and functionalities of these new materials opens up new possibilities for a broad range of applications, it also calls for structural modifications to existing safety assessment processes that are primarily focused on bulk material properties. Decades after the need to modify existing risk management practices to include nano-specific behaviors and exposure pathways was recognized, relevant policies for evaluating, and controlling health risks of nano-enabled materials is still lacking. This review provides an overview of current progress in the field of nanobiotechnology rather than intentions and aspirations, summarizes long-recognized but still unresolved issues surrounding materials safety at the nanoscale, and discusses key barriers preventing generation and integration of reliable data in bio/nano-safety domain. Particular attention is given to nanostructured materials that are commonly used in biomedical applications. © 2020 Informa UK Limited, trading as Taylor & Francis Group.

Bioengineering / Biyomühendislik

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