Bioengineering / Biyomühendislik

Permanent URI for this collectionhttps://hdl.handle.net/11147/4529

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COAR Access Rights: search.filters.coarAccessRights.open accessSubject: search.filters.subject.Lab-on-a-chip

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  • Review
    Citation - WoS: 30
    Citation - Scopus: 33
    Molecular Separation by Using Active and Passive Microfluidic Chip Designs: a Comprehensive Review
    (Wiley, 2023) Ebrahimi, Aliakbar; Didarian, Reza; Shih, Chih-Hsin; Nasseri, Behzad; Ethan Li, Yi-Chen; Shih, Steven; İçöz, Kutay; Tarım, Ergün Alperay; Akpek, Ali; Çeçen, Berivan; Bal Öztürk, Ayça; Güleç, Kadri; Tarım, Burcu Sırma; Tekin, Hüseyin Cumhur
    Separation and identification of molecules and biomolecules such as nucleic acids, proteins, and polysaccharides from complex fluids are known to be important due to unmet needs in various applications. Generally, many different separation techniques, including chromatography, electrophoresis, and magnetophoresis, have been developed to identify the target molecules precisely. However, these techniques are expensive and time consuming. “Lab-on-a-chip” systems with low cost per device, quick analysis capabilities, and minimal sample consumption seem to be ideal candidates for separating particles, cells, blood samples, and molecules. From this perspective, different microfluidic-based techniques have been extensively developed in the past two decades to separate samples with different origins. In this review, “lab-on-a-chip” methods by passive, active, and hybrid approaches for the separation of biomolecules developed in the past decade are comprehensively discussed. Due to the wide variety in the field, it will be impossible to cover every facet of the subject. Therefore, this review paper covers passive and active methods generally used for biomolecule separation. Then, an investigation of the combined sophisticated methods is highlighted. The spotlight also will be shined on the elegance of separation successes in recent years, and the remainder of the article explores how these permit the development of novel techniques. © 2023 The Authors. Advanced Materials Interfaces published by Wiley-VCH GmbH.
  • Conference Object
    Citation - WoS: 3
    Citation - Scopus: 3
    Active Mixing Strategy With Electromechanical Platform for Lab-On Applications
    (Institute of Electrical and Electronics Engineers Inc., 2019) Karakuzu, Betül; Özçivici, Engin; Tekin, Hüseyin Cumhur; Tarım, E. Alperay
    The main purpose of this study is to present a new active mixing strategy that can be used for lab-on-A-chip applications to shorten analysis time. An electromechanical platform composed of stepper and DC motors is designed and manufactured. This platform allows rapid mixing in microwells of a polydimethylsiloxane chip for analysis. Mixing in microwells is performed with a stirring bar spun automatically using the electromechanical platform. Mixing experiments performed at different spinning speeds and different time intervals on the platform. It was observed that mixing was achieved only in 300 ms inside 100 ?L microwell using 4300 revolutions per minute (rpm) spinning speeds. Hence, the proposed mixing strategy showed 200-fold faster mixing than pure diffusion-based mixing. © 2019 IEEE.