Bioengineering / Biyomühendislik
Permanent URI for this collectionhttps://hdl.handle.net/11147/4529
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Conference Object Investigation of Antimicrobial Activity To Determine Mic Value of Cinnamon Bark Oil Against Helicobacter Pylori(Wiley, 2014) Güneş, Seda; Becerikli, T.; Tıhmınlıoğlu, Funda; Yılmaz, Özlem[No abstract available]Conference Object In Vitro Evaluation of Bioactive Chitosan Microspheres for Eradicating Helicobacter Pylori Biofilm(Wiley, 2016) Güneş, Seda; Arslan, Nur; Demiray Gürbüz, Ebru; Tıhmınlıoğlu, Funda; Yılmaz, ÖzlemCertain H. pylori strains can form biofilm both inside and outside human host to protect itself under environmental stress. Biofilm contributes to development of antimicrobial resistance by some kind of mechanisms like providing a barrier for diffusion and allowing resistance gene expression.Conference Object Determination of Biofilm Formation by Helicobacter Pylori(Wiley, 2016) Arslan, Nur; Güneş, Seda; Demiray Gürbüz, Ebru; Tıhmınlıoğlu, Funda; Yılmaz, ÖzlemBackground : Certain H. pylori strains form biofilm in laboratory experiments and also on the surface of gastric mucosa, suggesting possible reason for eradication failure by increasing resistance to antimicrobial agents and transmission. Aim : To examine the mature biofilm formation by H. pylori NCTC11637 standard strain in different incubation periods for H. pylori biofilm characterization.Conference Object Evaluation of Anti-Inflammatory Potential and Lc-ms/Ms Analysis of Different Standards(Wiley, 2018) Sözmen, Alper Baran; Canbay, E.; Yıldırım Sözmen, Eser; Övez, BikemStandardization of a LC-MS/MS method for phenolic compound content of biomass originated extracts was aimed in this study, Chlorella miniata extracts, which were cultivated solely for this study, were used for this purpose. The first step of the study was to compare external standard method, added standard method, and conventional standard method the qualitative identification of phenolic compounds of the extracts were performed by using LC-MS/MS system.Article Citation - WoS: 5Citation - Scopus: 4Monitoring Neutropenia for Cancer Patients at the Point of Care(Wiley, 2017) İnan, Hakan; Kingsley, James L.; Özen, Mehmet O.; Tekin, Hüseyin Cumhur; Hoerner, Christian R.; Imae, Yoriko; Demirci, UtkanNeutrophils have a critical role in regulating the immune system. The immune system is compromised during chemotherapy, increasing infection risks and imposing a need for regular monitoring of neutrophil counts. Although commercial hematology analyzers are currently used in clinical practice for neutrophil counts, they are only available in clinics and hospitals, use large blood volumes, and are not available at the point of care (POC). Additionally, phlebotomy and blood processing require trained personnel, where patients are often admitted to hospitals when the infections are at late stage due to lack of frequent monitoring. Here, a reliable method is presented that selectively captures and quantifies white blood cells (WBCs) and neutrophils from a finger prick volume of whole blood by integrating microfluidics with high-resolution imaging algorithms. The platform is compact, portable, and easy to use. It captures and quantifies WBCs and neutrophils with high efficiency (> 95%) and specificity (> 95%) with an overall 4.2% bias compared to standard testing. The results from a small cohort of patients (N = 11 healthy, N = 5 lung and kidney cancer) present a unique disposable cell counter, demonstrating the ability of this tool to monitor neutrophil and WBC counts within clinical or in resource-constrained environments.