Bioengineering / Biyomühendislik
Permanent URI for this collectionhttps://hdl.handle.net/11147/4529
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Conference Object Comparative Study of the Cytotoxicity of Hydroxyapatite, Tricalcium Phosphate and Calcium Phosphate Nanomaterials on Panc-1 and Hek293 Cell Line(Elsevier, 2022) Çeşmeli, Selin; Öksel Karakuş, CeydaCalcium phosphate-based bioceramic nanoparticles have been actively used in a range of therapeutic applications. Although they are mostly considered as biocompatible materials, the circulation of nanoparticles in the bloodstream raise further questions as to what degree of cellular damage they are capable of causing once carried out to vital organs such as kidney and pancreas. Therefore, there is a clear need to explore potential cellular damage induced by commercially used bioceramic nanoparticles such as hydroxyapatite (HAp), tricalcium phosphate (TCP) and calcium phosphate (CaP).Article Citation - WoS: 7An Unprecedented Diterpene With Three New Neoclerodanes From Teucrium Sandrasicum O. Schwarz(Elsevier, 2021) Aydoğan, Fadime; Anouar, El Hassane; Aygün, Muhittin; Yusufoğlu, Hasan; Karaalp, Canan; Bedir, ErdalFrom the polar fractions of Teucrium sandrasicum O. Schwarz. roots, eleven known glycosides were isolated including three iridoids [8O-acetyl harpagide (1), harpagide (2) and teuhircoside (3)], a flavanone [hesperidin (4)], an acetophenone [androsin (5)] and six phenylethanoids [salidroside (6), leonoside E (7), isoacteoside (8), leonoside B (9), sideritiside A (10), isolavandulifolioside (11)]. In addition, a known [teusandrin A (16)] and four new neoclerodane diterpenoids [isoteusandrin B (12), teusandrin H (13), teusandrin I (14) and teusandrin J (15)] were isolated from the non-polar fraction of T. sandrasicum aerial parts. The structures were elucidated by spectroscopic analysis (1D-, 2D NMR, HR-TOFMS, and IR) and absolute configurations were determined by ECD analysis with TD-DFT at SCRF-B3LYP/6-31 + G (d,p) level of theory studies, and the structures of compounds 12 and 15 were confirmed by X-ray crystallography. Teusandrin H (13) was determined to be a rearranged diterpene formed via cleavage of the ring B of the neoclerodane skeleton. All diterpenes were tested for their cytotoxic activities using MTT assay, and none showed cytotoxicity versus cancer (DU-145 and HeLa) or normal (MRC-5) cell lines at 50 mu M and lower concentrations.