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Investigation of the Cytotoxicity of Bioceramic Nanoparticles on Saos-2 Cells by an Alternative Method
(Elsevier Ireland Ltd, 2022) Tomak, Aysel; Önder, A. C.; Öksel Karakuş, Ceyda
Novel Coronavirus Disease: Overview and Recent Situation
(İstanbul Üniversitesi-Cerrahpaşa Sağlık Bilimleri Fakültesi, 2020) Öksel, Ceyda; Bilgi, Eyüp; Başlar, Muhammet Semih; Çeşmeli, Selin; Tomak, Aysel; Hanoğlu, Berçem Dilan
In the last days of 2019, local hospitals in Wuhan city (population of 11 million) reported several pneumonia cases with unknown etiology among people linked to the Huanan Seafood Wholesale Market. The virus, which is thought to be the source of the unknown viral infection, was first identified as a new type of coronavirus on January 7, 2020. With the first case reported in Thailand about a week later, the virus’s spread outside the borders of China became apparent. In an alarmingly short time, the new type of coronavirus disease (called COVID-19) started to gain worldwide recognition with the detection of various COVID-19 cases in multiple countries, including Japan, South Korea, USA, Singapore, France, Germany, Italy, Spain, and England. As a result of its rampant spread and fatal clinical manifestations, the coronavirus outbreak was declared a pandemic on March 11, 2020, by the World Health Organization (WHO). Turkey announced its first confirmed case of COVID-19 on the same date that WHO characterized COVID-19 as a pandemic. As of April 2020, the COVID-19 pandemic has traveled to 209 countries and territories around the world, infecting more than 3 million people. Since specific treatment and vaccine for COVID-19 are not yet available, early case detection and preventive healthcare practices (isolation, social distancing, and personal hygiene) play a critical role in combating the COVID-19 outbreak. This review is intended to build an overall picture of the COVID-19 outbreak based on the available scientific knowledge.
Citation - WoS: 12
Citation - Scopus: 11
Theoretical and Experimental Investigation of Conjugation of 1,6-Hexanedithiol on Mos2
(IOP Publishing Ltd., 2018) Gül, Aytaç; Bacaksız, Cihan; Ünsal, Emre; Akbalı, Barış; Tomak, Aysel; Zareie, Hadi M.; Şahin, Hasan
We report an experimental and theoretical investigation of conjugation of 1,6-Hexaneditihiol (HDT) on MoS2 which is prepared by mixing MoS2 structure and HDT molecules in proper solvent. Raman spectra and the calculated phonon bands reveal that the HDT molecules bind covalently to MoS2. Surface morphology of MoS2/HDT structure is changed upon conjugation of HDT on MoS2 and characterized by using Scanning Electron Microscope (SEM). Density Functional Theory (DFT) based calculations show that HOMO-LUMO band gap of HDT is altered after the conjugation and two-S binding (handle-like) configuration is energetically most favorable among three different structures. This study displays that the facile thiol functionalization process of MoS2 is promising strategy for obtaining solution processable MoS2.
Citation - WoS: 36
Citation - Scopus: 38
Effect of Molecular Architecture on Cell Interactions and Stealth Properties of Peg
(American Chemical Society, 2017) Özer, İmran; Tomak, Aysel; Zareie, Hadi M.; Baran, Yusuf; Bulmuş, Volga
PEGylation, covalent attachment of PEG to therapeutic biomolecules, in which suboptimal pharmacokinetic profiles limiting their therapeutic utility are of concern, is a widely applied technology. However, this technology has been challenged by reduced bioactivity of biomolecules upon PEGylation and immunogenicity of PEG triggering immune response and abrogating clinical efficacy, which collectively necessitate development of stealth polymer alternatives. Here we demonstrate that comb-shape poly[oligo(ethylene glycol) methyl ether methacrylate] (POEGMA), a stealth polymer alternative, has a more compact structure than PEG and self-organize into nanoparticles in a molecular weight dependent manner. Most notably, we show that comb-shape POEGMA promotes significantly higher cellular uptake and exhibits less steric hindrance imposed on the conjugated biomolecule than PEG. Collectively, comb-shape POEGMA offers a versatile alternative to PEG for stealth polymer-biomolecule conjugation applications.

Bioengineering / Biyomühendislik

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