PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7645
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Article Citation - WoS: 8Citation - Scopus: 10Auditory Event-Related Potentials Demonstrate Early Cognitive Impairment in Children With Subclinical Hypothyroidism(Walter de Gruyter GmbH, 2019) Çatlı, Gönül; Kocaaslan Atlı, Sibel; Olgaç Dündar, Nihal; Bayazıt, Onur; Evirgen Esin, Nur; Erdoğan, Uğraş; Dündar, Bumin NuriBackground: The aim of this study was to examine the cognitive functions of children with subclinical hypothyroidism (SH) and healthy children with the use of auditory event-related potentials (AERPs) and neuropsychological tests. Methods: Twenty children aged between 8 and 17 wars, diagnosed with SH, and 20 age-matched healthy controls were included in this study. A classical auditory oddball paradigm was applied during the electroencephalography (EEG) recordings, and event-related potentials (ERPs) were evaluated between the 0.5- and 20-Hz frequency intervals. P1, N1, P2, N2 and P3 amplitudes and latencies were measured in Fz, FCz, Cz, CPz, Pz and Oz electrodes. Additionally, a number of neuropsychological tests evaluating the reaction time and various cognitive functions were carried out. Results: In children with SH, P3 amplitudes in FCz, Cz and CPz electrodes were significantly lower than those in controls (p <0.05). In addition to this, the P1N1 and N1P2 peak-to-peak amplitude values were also found to be smaller for children with SH than controls (p <0.05). With regard to the neuropsychological tests, no significant difference was observed between the SH and control groups on any of the cognitive test parameters, reaction time or correct response rates. Conclusions: In the present study, while children with SI I did not differ from controls with respect to their cognitive functions evaluated via neuropsychological tests, cognitive differences were detected via electrophysiological investigations. This result implies that implicit changes in cognition which are not yet overtly reflected on neuropsychological tests may be detected at an early stage in children with SH.Article Citation - WoS: 14Visualization and Analysis of Micrornas Within Kegg Pathways Using Vanesa(Walter de Gruyter GmbH, 2017) Hamzeiy, Hamid; Suluyayla, Rabia; Brinkrolf, Christoph; Janowski, Sebastian Jan; Hofestaedt, Ralf; Allmer, JensMicroRNAs (miRNAs) are small RNA molecules which are known to take part in post-transcriptional regulation of gene expression. Here, VANESA, an existing platform for reconstructing, visualizing, and analysis of large biological networks, has been further expanded to include all experimentally validated human miRNAs available within miRBase, TarBase and miRTarBase. This is done by integrating a custom hybrid miRNA database to DAWIS-M.D., VANESA's main data source, enabling the visualization and analysis of miRNAs within large biological pathways such as those found within the Kyoto Encyclopedia of Genes and Genomes (KEGG). Interestingly, 99.15 % of human KEGG pathways either contain genes which are targeted by miRNAs or harbor them. This is mainly due to the high number of interaction partners that each miRNA could have (e.g.: hsa-miR-335-5p targets 2544 genes and 71 miRNAs target NUFIP2). We demonstrate the usability of our system by analyzing the measles virus KEGG pathway as a proof-of-principle model and further highlight the importance of integrating miRNAs (both experimentally validated and predicted) into biological networks for the elucidation of novel miRNA-mRNA interactions of biological importance.Article Citation - WoS: 2Citation - Scopus: 2Staphylococcus Epidermidis Adhesion on Surface-Treated Open-Cell Ti6al4v Foams(Walter de Gruyter GmbH, 2016) Türkan, Uğur; Güden, Mustafa; Sudağıdan, MertThe effect of alkali and nitric acid surface treatments on the adhesion of Staphylococcus epidermidis to the surface of 60% porous open-cell Ti6Al4V foam was investigated. The resultant surface roughness of foam particles was determined from the ground flat surfaces of thin foam specimens. Alkali treatment formed a porous, rough Na2Ti5O11 surface layer on Ti6Al4V particles, while nitric acid treatment increased the number of undulations on foam flat and particle surfaces, leading to the development of finer surface topographical features. Both surface treatments increased the nanometric-scale surface roughness of particles and the number of bacteria adhering to the surface, while the adhesion was found to be significantly higher in alkali-treated foam sample. The significant increase in the number of bacterial attachment on the alkali-treated sample was attributed to the formation of a highly porous and nanorough Na2Ti5O11 surface layer.