PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7645

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Author: search.filters.author.Ceylan, Seyit MehmetScopus Q: search.filters.scopusQuartile.Q2

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  • Article
    Citation - WoS: 8
    The Effects of Halofuginone on Wound Healing in the Rat Nasal Mucosa
    (Sage Publications Inc, 2020) Ceylan, Seyit Mehmet; Uysal, Erdal; Sokucu, Mehmet; Sezgin, Efe; Kanmaz, Mahmut Alper; Yurtseven, Duygu Gok; Bilal, Nagihan
    Background Halofuginone is an alkaloid febrifugine analogue and bioactive molecule that was isolated incidentally from the Dichroa febrifuga plant. The therapeutic efficacy of halofuginone in parasitic infections, scleroderma, inflammation, and fibrosis-related diseases, as well as in some types of cancer, has been previously reported. The effects of halofuginone on nasal mucosal damage are not yet known. Objective The aim of this study was to investigate the potential effect of topically applied halofuginone on wound healing in the mechanically injured nasal mucosa of rats. Methods A unilateral mucosal wound was created in the nasal cavity of 32 rats (aged 4 weeks) using the brushing technique. These rats were randomly divided into 4 groups. Although the control group did not receive an intervention, a dry pad, a saline-impregnated pad, or a pad impregnated with halofuginone were placed in the rats of the other 3 groups and left for 5 minutes. Rats were sacrificed on the 14th day, and a histological examination was performed. The nasal mucosa was assessed via hematoxylin-eosin and Masson's trichrome staining. Results There were no statistically significant differences in epithelial thickness, inflammation, goblet cell formation, and epithelial disarray values between the halofuginone group and the control group (P > .05). The subepithelial thickness was significantly decreased in the saline-treated group and the halofuginone-treated group (P < .05), but a significantly lower level of subepithelial fibrosis was only observed in the halofuginone group compared to the other groups (P < .05). Conclusions Topical halofuginone administration reduces the development of fibrosis and subepithelial edema after experimentally induced nasal mucosal injury, but it does not exert therapeutic or preventive effects on epithelial damage, inflammation, and goblet cell hyperplasia.
  • Article
    Citation - WoS: 2
    Citation - Scopus: 2
    Hot Nasal Packing With Hot Saline Irrigation for Hemostasis After Adenoidectomy: a Prospective Randomized Controlled Study
    (Elsevier, 2020) Ceylan, Seyit Mehmet; Dişikırık, İlyas; Kanmaz, Mahmut Alper; Yıldırım, Alton; Sezgin, Efe
    Objective: This study aimed to investigate the efficacy of hot posterior nasal packing and hot saline irrigation in bleeding control after adenoidectomy. Methods: A total of 130 patients scheduled for adenoidectomy were included in the study, and randomized into two groups at the beginning of the surgical operation. After adenoidectomy, saline impregnated tampon, and saline irrigation at room temperature (22 degrees C) was applied to the patients in one group while 50 degrees C saline impregnated tampon and saline irrigation at the same temperature were applied to the patients in the other group. We recorded hemostasis for up to 3 min after tamponade for bleeding control, and the amount of bleeding into the nasopharynx. Results: The age of the patients ranged from 1.5 to 13 years (mean +/- SD: 6.07 +/- 3.08 years, and 5.33 +/- 2.55 years, 22 degrees C and 50 degrees C saline irrigation groups, respectively). There were 37 males and 28 females in the 22 degrees C saline group, while 34 males and 31 females in the 50 degrees C saline group. When comparing the two groups, there was no statistically significant difference in terms of duration of hemostasis (p = 0.64). However, bleeding scores at 2 nd min after the tamponade were significantly lower in the 50 degrees C saline group (p = 0.007). The amount of bleeding in the 50 degrees C saline group was also significantly lower than the 22 degrees C saline group (p = 0.015). Conclusion: In this study, application of 50 degrees C saline impregnated tampon, and hot saline irrigation was found to be more effective in the control of bleeding after adenoidectomy by reducing the amount of bleeding compared to 22 degrees C saline impregnated tampon application and saline irrigation at 22 degrees C. However, hot nasal packing and hot saline irrigation did not affect duration of hemostasis and cauterization.