PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7645

Browse

Filters

2023 - 20252

Settings

Author: search.filters.author.Eren, Merve CevikDepartment: search.filters.department.İzmir Institute of Technology

Search Results

Now showing 1 - 2 of 2
  • Article
    Comparative Stability of Synthetic and Natural Polymeric Micelles in Physiological Environments: Implications for Drug Delivery
    (MDPI, 2025) Polat, Hürriyet; Polat, Mehmet; Polat, Mehmet; Koss, Kyle M.; Polat, Onur K.; 04.01. Department of Chemistry; 04. Faculty of Science; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
    Polymeric micelles are widely studied as nanocarriers for hydrophobic drugs, yet their structural stability under physiological conditions remains a major limitation. This review provides a comparative evaluation of synthetic and natural polymeric micelles with a focus on their stability under dilution and in protein-rich environments. The discussion integrates thermodynamic and kinetic factors governing micelle integrity and examines how molecular composition, hydrophobic segment length, and core-shell modifications influence disintegration behavior. While synthetic micelles commonly collapse below their critical micelle concentration during intravenous administration, natural polymeric micelles, such as those derived from chitosan, alginate, or heparin, exhibit improved resistance to dilution but remain vulnerable to protein-induced destabilization. Strategies such as core or shell cross-linking, surface functionalization, and natural polymer coatings are reviewed as promising approaches to enhance circulation stability and controlled drug release. The work provides a framework for designing micellar systems with balanced biocompatibility, biodegradability, and robustness suitable for clinical drug-delivery applications.
  • Article
    Citation - Scopus: 3
    A Reaction-Based Scenario for Fluorescence Probing of Au(iii) Ions in Human Cells and Plants
    (Royal Soc Chemistry, 2023) Eren, Merve Cevik; Emrullahoğlu, Mustafa; Dartar, Suay; Varlıklı, Canan; Kaya, Beraat Umur; Varlikli, Canan; Emrullahoglu, Mustafa; 04.01. Department of Chemistry; 01. Izmir Institute of Technology; 04.04. Department of Photonics; 04. Faculty of Science
    A BODIPY-based fluorophore decorated with a gold specific reactive handle (e.g., 2-alkynylallyl alcohol) displayed a ratiometric fluorescence change in response to Au3+ ions with extraordinary selectivity over other competing metal species, including Hg2+, Cu2+, Zn2+ and Pd2+. By way of a gold-catalyzed intramolecular cyclisation-isomerisation reaction sequence, a BODIPY construct with an extended p-conjugation transformed into a new structure with a relatively short p-system. This unique chemical transformation was accompanied by, and resulted in, a dramatic shift in the emission and absorption wavelength, which could be monitored as distinct changes in the color of the solution's emission. Apart from its outstanding analytical performance in solution, including a quick response time (<10 s), unique specificity, a high-fold ratio-metric change (62-fold), and a remarkably low detection limit (358 nM), the probe also proved useful in monitoring Au3+ ions in human cells and plants (e.g., Nicotiana benthamiana).