PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7645
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Article Citation - WoS: 8Protective and Therapeutic Effects of Milrinone on Acoustic Trauma in Rat Cochlea(Springer, 2019) Sezgin, Efe; Uysal, Erdal; Altinay, Serdar; Sezgin, Efe; Bilal, Nagihan; Petekkaya, Emine; Gulbagci, Mustafa Emre; 03.08. Department of Food Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyObjectiveThe aim of this study was to investigate the potential protective and therapeutic effects of milrinone, a specific phosphodiesterase (PDE) III inhibitor, on acoustic trauma-induced cochlear injury and apoptosis.MethodsA total number of 30 healthy Wistar albino rats were evenly divided into five groups as follows: group 1 was assigned as control group; group 2 and 3 were assigned as low-dosage groups (0.25mg/kg) in which milrinone was administered 1h before acoustic trauma (AT) and 2h after AT, respectively; group 4 and 5 were assigned as high-dosage groups (0.50mg/kg) in which the drug was administered 1h before AT and 2h after AT, respectively. Except control group, all treatment groups received a single dosage of milrinone for 5days. Distortion product otoacoustic emissions (DPOAE) measurements were recorded before AT as well as at second and fifth post-traumatic days. At the end of fifth day, all rats were sacrificed and the cochlea of the rats was removed for histopathological evaluation. In addition, the groups were compared in terms of apoptotic index via caspase-3 staining.ResultsIn terms of signal-to-noise ratio (SNR), there was no statistically significant difference among the groups following AT (p>0.05). After 5days of milrinone treatment, the best SNR values were found in group 5, though all groups did not statistically differ (p>0.05). In histopathological evaluation, vacuolization, inflammation, and edema scores in all treatment groups were statistically lower than those of the control group (p<0.05). In group 2 and 4 where the drug was administered before AT, the inflammation and apoptosis index was lower than those of group 3 and 5 where the drug was administered after AT (p<0.0001).ConclusionWe reveal that milrinone has a protective effect on cochlear damage in the experimental acoustic model of rats. This protective effect was more apparent following the pre-traumatic milrinone administration, and is associated with its effect on decreasing inflammation and apoptosis. Based on DPOAE measurements following AT, especially in the group 5 (high-dosage group), milrinone may also have a therapeutic effect.Conference Object Citation - WoS: 24Effect of pH and Hydration on the Normal and Lateral Interaction Forces Between Alumina Surfaces(2006) Polat, Mehmet; Sato, Kimiyasu; Nagaoka, Takaaki; Watari, Koji; 01. Izmir Institute of Technology; 03. Faculty of Engineering; 03.02. Department of Chemical EngineeringNormal and lateral interaction forces between alumina surfaces were measured using Atomic Force Microscopy-Colloid Probe Method at different pH. The normal force curves exhibit a well-defined repulsive barrier and an attractive minimum at acidic pH and the DLVO theory shows excellent agreement with the data. The normal forces are always repulsive at basic pH and the theory fails to represent the measurements. Lateral forces are almost an order of magnitude smaller in the basic solutions. These differences, which have important implications in the study of stability and rheology, are attributed to the hydration of the alumina surface at basic pH. © 2013 Elsevier B.V., All rights reserved.Article Tc-99m Erythromycin Lactobionate Inhalation Scintigraphy in Parenchymal Lung Diseases(Elsevier Science inc, 1999) Durak, H; Aktogu, S; Degirmenci, B; Sayit, E; Ertay, T; Dereli, S; 01. Izmir Institute of TechnologyWe have investigated Technetium 99m erythromycin lactobionate (Tc 99m EL) clearance from the lungs after inhalation, in the presence of an alveolitis. Eighteen patients (6 sarcoidosis, 7 idiopathic fibrosis, and 5 miliary tuberculosis) were imaged after the patients inhaled 1,110 MBq of Tc 99m EL. Clearance half time for the first 45 min, for 24 h, and retention at 24 h correlated with percentage of lymphocytes in bronchoalveolar lavage fluid (BAL) (r =.729, r =.883, and r =.826, respectively). There was a positive correlation between peripheral penetration (PP) and forced expiratory volume in 1 s (FEV1) (r =.806) and forced vital capacity (FVC) (r =.781). Retention was more marked in sarcoidosis compared with tuberculosis (0.025 < p less than or equal to 0.05). Radioaerosol lung imaging may reflect the pulmonary function impairment in parenchymal lung diseases. Retention of Tc 99m EL may be related to number of BAL cells or presence of a lymphocytic alveolitis. Long residency time of Tc 99m EL in the lungs implies that erythromycin can also be administered by inhalation for therapeutic purposes. NUCL MED BIOL 26;6:695-698, 1999. (C) 1999 Elsevier Science Inc. All rights reserved.Article Citation - WoS: 15Citation - Scopus: 18Search for Supersymmetry in pp Collisions at √s=13 TeV in the Single-Lepton Final State Using the Sum of Masses of Large-Radius Jets(Amer Physical Soc, 2017) Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Ambrogi, F.; Asilar, E.; Bergauer, T.; Woods, N.; 01. Izmir Institute of TechnologyResults are reported from a search for supersymmetric particles in proton-proton collisions in the final state with a single lepton, multiple jets, including at least one b-tagged jet, and large missing transverse momentum. The search uses a sample of proton-proton collision data at root s = 13 TeV recorded by the CMS experiment at the LHC, corresponding to an integrated luminosity of 35.9 fb(-1). The observed event yields in the signal regions are consistent with those expected from standard model backgrounds. The results are interpreted in the context of simplified models of supersymmetry involving gluino pair production, with gluino decay into either on- or off-mass-shell top squarks. Assuming that the top squarks decay into a top quark plus a stable, weakly interacting neutralino, scenarios with gluino masses up to about 1.9 TeV are excluded at 95% confidence level for neutralino masses up to about 1 TeV.Article Citation - WoS: 105Evidence of B-Jet Quenching in PbPb Collisions at √sNN=2.76 TeV(American Physical Society, 2014) Chatrchyan, S.; Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Bergauer, T.; Smith, W. H.; 01. Izmir Institute of TechnologyThe production of jets associated to bottom quarks is measured for the first time in PbPb collisions at a center-of-mass energy of 2.76 TeV per nucleon pair. Jet spectra are reported in the transverse momentum (p(T)) range of 80-250 GeV/c, and within pseudorapidity |eta| < 2. The nuclear modification factor (RAA) calculated from these spectra shows a strong suppression in the b-jet yield in PbPb collisions relative to the yield observed in pp collisions at the same energy. The suppression persists to the largest values of p(T) studied, and is centrality dependent. The R-AA is about 0.4 in the most central events, similar to previous observations for inclusive jets. This implies that jet quenching does not have a strong dependence on parton mass and flavor in the jet p(T) range studied.Article Citation - WoS: 72Citation - Scopus: 72Measurement of J /Ψ and Ψ (2s) Prompt Double-Differential Cross Sections in Pp Collisions at S =7tev(American Physical Society, 2015) Khachatryan, V.; Sirunyan, A.M.; Tumasyan, A.; Adam, W.; Bergauer, T.; Dragicevic, M.; Innocente, V.; 01. Izmir Institute of TechnologyThe double-differential cross sections of promptly produced J/ψ and ψ(2S) mesons are measured in pp collisions at s=7TeV, as a function of transverse momentum pT and absolute rapidity |y|. The analysis uses J/ψ and ψ(2S) dimuon samples collected by the CMS experiment, corresponding to integrated luminosities of 4.55 and 4.90fb-1, respectively. The results are based on a two-dimensional analysis of the dimuon invariant mass and decay length, and extend to pT=120 and 100 GeV for the J/ψ and ψ(2S), respectively, when integrated over the interval |y|<1.2. The ratio of the ψ(2S) to J/ψ cross sections is also reported for |y|<1.2, over the range 10<pT<100GeV. These are the highest pT values for which the cross sections and ratio have been measured. © 2015 CERN, for the CMS Collaboration.Article Citation - WoS: 33Citation - Scopus: 45Measurement of the Triple-Differential Dijet Cross Section in Proton-Proton Collisions at √s=8tev and Constraints on Parton Distribution Functions(Springer Nature, 2017) Sirunyan, A.M.; Karapınar, Güler; Adam, W.; Asilar, E.; Bergauer, T.; Brandstetter, J.; Barney, D.; 01. Izmir Institute of TechnologyA measurement is presented of the triple-differential dijet cross section at a centre-of-mass energy of 8TeV using 19.7fb-1 of data collected with the CMS detector in proton-proton collisions at the LHC. The cross section is measured as a function of the average transverse momentum, half the rapidity separation, and the boost of the two leading jets in the event. The cross section is corrected for detector effects and compared to calculations in perturbative quantum chromodynamics at next-to-leading order accuracy, complemented with electroweak and nonperturbative corrections. New constraints on parton distribution functions are obtained and the inferred value of the strong coupling constant is αS(MZ)=0.1199±0.0015(exp)-0.0020+0.0031(theo), where MZ is the mass of the Z boson. © 2017, CERN for the benefit of the CMS collaboration.Article Citation - WoS: 37Citation - Scopus: 43Search for Heavy Resonances That Decay Into a Vector Boson and a Higgs Boson in Hadronic Final States at √s=13tev(Springer Nature, 2017) Sirunyan, A.M.; Karapınar, Güler; Adam, W.; Ambrogi, F.; Asilar, E.; Bergauer, T.; Ruiz-Jimeno, A.; 01. Izmir Institute of TechnologyA search for heavy resonances with masses above 1TeV, decaying to final states containing a vector boson and a Higgs boson, is presented. The search considers hadronic decays of the vector boson, and Higgs boson decays to b quarks. The decay products are highly boosted, and each collimated pair of quarks is reconstructed as a single, massive jet. The analysis is performed using a data sample collected in 2016 by the CMS experiment at the LHC in proton-proton collisions at a center-of-mass energy of 13TeV, corresponding to an integrated luminosity of 35.9fb-1. The data are consistent with the background expectation and are used to place limits on the parameters of a theoretical model with a heavy vector triplet. In the benchmark scenario with mass-degenerate W′ and Z ′ bosons decaying predominantly to pairs of standard model bosons, for the first time heavy resonances for masses as high as 3.3TeV are excluded at 95% confidence level, setting the most stringent constraints to date on such states decaying into a vector boson and a Higgs boson. © 2017, CERN for the benefit of the CMS collaboration.Article Citation - WoS: 104Citation - Scopus: 119Search for New Phenomena With the Mt 2 Variable in the All-Hadronic Final State Produced in Proton–proton Collisions at √s=13tev(Springer Nature, 2017) Sirunyan, A.M.; Karapınar, Güler; Johnson, A.; Adam, W.; Ambrogi, F.; Asilar, E.; Scodellaro, L.; 01. Izmir Institute of TechnologyA search for new phenomena is performed using events with jets and significant transverse momentum imbalance, as inferred through the MT 2 variable. The results are based on a sample of proton–proton collisions collected in 2016 at a center-of-mass energy of 13TeV with the CMS detector and corresponding to an integrated luminosity of 35.9fb-1. No excess event yield is observed above the predicted standard model background, and the results are interpreted as exclusion limits at 95% confidence level on the masses of predicted particles in a variety of simplified models of R-parity conserving supersymmetry. Depending on the details of the model, 95% confidence level lower limits on the gluino (light-flavor squark) masses are placed up to 2025 (1550)GeV. Mass limits as high as 1070 (1175)GeV are set on the masses of top (bottom) squarks. Information is provided to enable re-interpretation of these results, including model-independent limits on the number of non-standard model events for a set of simplified, inclusive search regions. © 2017, CERN for the benefit of the CMS collaboration.Article Citation - WoS: 33Citation - Scopus: 38Search for Dark Matter Produced in Association With Heavy-Flavor Quark Pairs in Proton-Proton Collisions at √s=13tev(Springer Nature, 2017) Sirunyan, A.M.; Karapınar, Güler; Adam, W.; Asilar, E.; Bergauer, T.; Brandstetter, J.; Dorney, B.; 01. Izmir Institute of TechnologyA search is presented for an excess of events with heavy-flavor quark pairs (tt¯ and bb¯) and a large imbalance in transverse momentum in data from proton–proton collisions at a center-of-mass energy of 13TeV. The data correspond to an integrated luminosity of 2.2fb-1 collected with the CMS detector at the CERN LHC. No deviations are observed with respect to standard model predictions. The results are used in the first interpretation of dark matter production in tt¯ and bb¯ final states in a simplified model. This analysis is also the first to perform a statistical combination of searches for dark matter produced with different heavy-flavor final states. The combination provides exclusions that are stronger than those achieved with individual heavy-flavor final states. © 2017, CERN for the benefit of the CMS collaboration.