PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
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Article Citation - WoS: 8Protective and Therapeutic Effects of Milrinone on Acoustic Trauma in Rat Cochlea(Springer, 2019) Ceylan, Seyit Mehmet; Uysal, Erdal; Altinay, Serdar; Sezgin, Efe; Bilal, Nagihan; Petekkaya, Emine; Gulbagci, Mustafa EmreObjectiveThe aim of this study was to investigate the potential protective and therapeutic effects of milrinone, a specific phosphodiesterase (PDE) III inhibitor, on acoustic trauma-induced cochlear injury and apoptosis.MethodsA total number of 30 healthy Wistar albino rats were evenly divided into five groups as follows: group 1 was assigned as control group; group 2 and 3 were assigned as low-dosage groups (0.25mg/kg) in which milrinone was administered 1h before acoustic trauma (AT) and 2h after AT, respectively; group 4 and 5 were assigned as high-dosage groups (0.50mg/kg) in which the drug was administered 1h before AT and 2h after AT, respectively. Except control group, all treatment groups received a single dosage of milrinone for 5days. Distortion product otoacoustic emissions (DPOAE) measurements were recorded before AT as well as at second and fifth post-traumatic days. At the end of fifth day, all rats were sacrificed and the cochlea of the rats was removed for histopathological evaluation. In addition, the groups were compared in terms of apoptotic index via caspase-3 staining.ResultsIn terms of signal-to-noise ratio (SNR), there was no statistically significant difference among the groups following AT (p>0.05). After 5days of milrinone treatment, the best SNR values were found in group 5, though all groups did not statistically differ (p>0.05). In histopathological evaluation, vacuolization, inflammation, and edema scores in all treatment groups were statistically lower than those of the control group (p<0.05). In group 2 and 4 where the drug was administered before AT, the inflammation and apoptosis index was lower than those of group 3 and 5 where the drug was administered after AT (p<0.0001).ConclusionWe reveal that milrinone has a protective effect on cochlear damage in the experimental acoustic model of rats. This protective effect was more apparent following the pre-traumatic milrinone administration, and is associated with its effect on decreasing inflammation and apoptosis. Based on DPOAE measurements following AT, especially in the group 5 (high-dosage group), milrinone may also have a therapeutic effect.Article Citation - WoS: 15Citation - Scopus: 18Search for Supersymmetry in pp Collisions at √s=13 TeV in the Single-Lepton Final State Using the Sum of Masses of Large-Radius Jets(Amer Physical Soc, 2017) Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Ambrogi, F.; Asilar, E.; Bergauer, T.; Woods, N.Results are reported from a search for supersymmetric particles in proton-proton collisions in the final state with a single lepton, multiple jets, including at least one b-tagged jet, and large missing transverse momentum. The search uses a sample of proton-proton collision data at root s = 13 TeV recorded by the CMS experiment at the LHC, corresponding to an integrated luminosity of 35.9 fb(-1). The observed event yields in the signal regions are consistent with those expected from standard model backgrounds. The results are interpreted in the context of simplified models of supersymmetry involving gluino pair production, with gluino decay into either on- or off-mass-shell top squarks. Assuming that the top squarks decay into a top quark plus a stable, weakly interacting neutralino, scenarios with gluino masses up to about 1.9 TeV are excluded at 95% confidence level for neutralino masses up to about 1 TeV.Article Citation - WoS: 73Measurement of the Polarization of W Bosons With Large Transverse Momenta in W Plus Jets Events at the Lhc(American Physical Society, 2011) Karapınar, GülerA first measurement of the polarization of W bosons with large transverse momenta in pp collisions is presented. The measurement is based on 36 pb(-1) of data recorded at root s = 7 TeV by the CMS detector at the LHC. The left-handed, right-handed, and longitudinal polarization fractions (f(L), f(R), and f(0), respectively) of W bosons with transverse momenta larger than 50 GeV are determined by using decays to both electrons and muons. The muon final state yields the most precise measurement: (f(L) - f(R))(-) = 0.240 +/- 0.036(syst) +/- 0.031(syst) and f(0)(-) = 0.183 +/- 0.087(stat) +/- 0.123(syst) for negatively charged W bosons and (f(L) - f(R))(+) = 0.310 +/- 0.036(syst) +/- 0.017(syst) and f(0)(+) = 0.171 +/- 0.085(syst) +/- 0.099(syst) for positively charged W bosons. This establishes, for the first time, that W bosons produced in pp collisions with large transverse momenta are predominantly left-handed, as expected in the standard model.Article Citation - WoS: 47Search for Heavy Neutrinos and W-R Bosons With Right-Handed Couplings in a Left-Right Symmetric Model in Pp Collisions at Root S=7 Tev(American Physical Society, 2012) Karapınar, GülerResults are presented from a search for heavy, right-handed muon neutrinos, N-mu, and right-handed W-R bosons, which arise in the left-right symmetric extensions of the standard model. The analysis is based on a 5: 0 fb(-1) sample of proton-proton collisions at a center-of-mass energy of 7 TeV, collected by the CMS detector at the Large Hadron Collider. No evidence is observed for an excess of events over the standard model expectation. For models with exact left-right symmetry, heavy right-handed neutrinos are excluded at 95% confidence level for a range of neutrino masses below the WR mass, dependent on the value of M-WR. The excluded region in the two-dimensional (M-WR, MN mu) mass plane extends to M-WR = 2.5TeV. DOI: 10.1103/PhysRevLett.109.261802Article Citation - WoS: 20Measurement of the Azimuthal Anisotropy of Neutral Pions in Pb-Pb Collisions at Root S-Nn=2.76 Tev(American Physical Society, 2013) Karapınar, GülerFirst measurements of the azimuthal anisotropy of neutral pions produced in Pb-Pb collisions at a center-of-mass energy of root S-NN = 2.76 TeV are presented. The amplitudes of the second Fourier component (upsilon(2)) of the pi(0) azimuthal distributions are extracted using an event-plane technique. The values of upsilon(2) are studied as a function of the neutral pion transverse momentum (p(T)) for different classes of collision centrality in the kinematic range 1.6< p(T)<8.0 GeV/c, within the pseudorapidity interval vertical bar eta vertical bar < 0.8. The CMS measurements of upsilon(2)(p(T)) are similar to previously reported pi(0) azimuthal anisotropy results from root S-NN = 200 GeV Au-Au collisions at RHIC, despite a factor of similar to 14 increase in the centerof-mass energy. In the momentum range 2.5<p(T)<5.0 GeV/c, the neutral pion anisotropies are found to be smaller than those observed by CMS for inclusive charged particles. DOI: 10.1103/PhysRevLett.110.042301Article Citation - WoS: 131Evidence for Associated Production of a Single Top Quark and W Boson in Pp Collisions at Root S=7 Tev(American Physical Society, 2013) Karapınar, GülerEvidence is presented for the associated production of a single top quark and W boson in pp collisions at root s = 7 TeV with the CMS experiment at the LHC. The analyzed data correspond to an integrated luminosity of 4.9 fb(-1). The measurement is performed using events with two leptons and a jet originated from a b quark. A multivariate analysis based on kinematic properties is utilized to separate the t (t) over bar background from the signal. The observed signal has a significance of 4.0 sigma and corresponds to a cross section of 16(-4)(+5) pb, in agreement with the standard model expectation of 15.6 +/- 0.4(-1.2)(+1.0) pb. DOI: 10.1103/PhysRevLett.110.022003Article Citation - WoS: 47Search for Pair Production of Third-Generation Leptoquarks and Top Squarks in Pp Collisions at Root S=7 Tev(American Physical Society, 2013) Karapınar, GülerResults are presented from a search for the pair production of third-generation scalar and vector leptoquarks, as well as for top squarks in R-parity-violating supersymmetric models. In either scenario, the new, heavy particle decays into a tau lepton and a b quark. The search is based on a data sample of pp collisions at root s = 7 TeV, which is collected by the CMS detector at the LHC and corresponds to an integrated luminosity of 4.8 fb(-1). The number of observed events is found to be in agreement with the standard model prediction, and exclusion limits on mass parameters are obtained at the 95% confidence level. Vector leptoquarks with masses below 760 GeV are excluded and, if the branching fraction of the scalar leptoquark decay to a tau lepton and a b quark is assumed to be unity, third-generation scalar leptoquarks with masses below 525 GeV are ruled out. Top squarks with masses below 453 GeV are excluded for a typical benchmark scenario, and limits on the coupling between the top squark, tau lepton, and b quark, lambda'(333) are obtained. These results are the most stringent for these scenarios to date. DOI: 10.1103/PhysRevLett.110.081801Article Citation - WoS: 303Study of the Mass and Spin-Parity of the Higgs Boson Candidate Via Its Decays To Z Boson Pairs(American Physical Society, 2013) Karapınar, GülerA study is presented of the mass and spin-parity of the new boson recently observed at the LHC at a mass near 125 GeV. An integrated luminosity of 17: 3 fb(-1), collected by the CMS experiment in proton-proton collisions at center-of-mass energies of 7 and 8 TeV, is used. The measured mass in the ZZ channel, where both Z bosons decay to e or mu pairs, is 126: 2 +/- 0.6(stat) +/- 0. 2(syst) GeV. The angular distributions of the lepton pairs in this channel are sensitive to the spin-parity of the boson. Under the assumption of spin 0, the present data are consistent with the pure scalar hypothesis, while disfavoring the pure pseudoscalar hypothesis. DOI: 10.1103/PhysRevLett.110.081803Article Citation - WoS: 45Measurement of Associated Production of Vector Bosons and Top Quark-Antiquark Pairs in Pp Collisions at Root S=7 Tev(American Physical Society, 2013) Karapınar, GülerThe first measurement of vector-boson production associated with a top quark-antiquark pair in proton-proton collisions at root s = 7 TeV is presented. The results are based on a data set corresponding to an integrated luminosity of 5.0 fb(-1), recorded by the CMS detector at the LHC in 2011. The measurement is performed in two independent channels through a trilepton analysis of t (t) over barZ events and a same-sign dilepton analysis of t (t) over barV (V = W or Z) events. In the trilepton channel a direct measurement of the t (t) over barZ cross section sigma(t (t) over barZ) = 0.28(-0.11)(+0.14) (stat)(-0.03)(+0.06) (syst) pb is obtained. In the dilepton channel a measurement of the t (t) over barV cross section yields sigma(t (t) over barV) = 0.43(-0.15)(+0.17) (stat)(-0.07)(+0.09) (syst) pb. These measurements have a significance, respectively, of 3.3 and 3.0 standard deviations from the background hypotheses and are compatible, within uncertainties, with the corresponding next-to-leading order predictions of 0.137(-0.016)(+0.012) and 0.306(-0.053)(+0.031) pb. DOI: 10.1103/PhysRevLett.110.172002Article Citation - WoS: 72Search for a Standard-Model Higgs Boson With a Mass in the Range 145 To 1000 Gev at the Lhc(Springer Verlag, 2013) Karapınar, Güler; CMS CollaborationA search for a standard-model-like Higgs boson in the H -> WW and H -> ZZ decay channels is reported, for Higgs boson masses in the range 145 < m(H) < 1000 GeV. The search is based upon proton-proton collision data samples corresponding to an integrated luminosity of up to 5.1 fb(-1) at root s = 7 TeV and up to 5.3 fb(-1) at root s = 8 TeV, recorded by the CMS experiment at the LHC. The combined upper limits at 95 % confidence level on products of the cross section and branching fractions exclude a standard-model-like Higgs boson in the range 145 < m(H) < 710 GeV, thus extending the mass region excluded by CMS from 127-600 GeV up to 710 GeV.