PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7645

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Department: search.filters.department.İzmir Institute of TechnologyPublisher: search.filters.publisher.Royal Society of Chemistry

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  • Article
    Iron Oxide Nanocube Assembly on Silver Nanowire Templates to Enhance Magnetic Hyperthermia Performance
    (Royal Society of Chemistry, 2026) Balcı, Sinan; Tiryaki, Ecem; Sadeghi, Ehsan; Mannir, Abubakar R.; Balci, Sinan; Pellegrino, Teresa; 04.04. Department of Photonics; 04. Faculty of Science; 01. Izmir Institute of Technology
    Iron oxide nanocubes (IONCs) represent one of the benchmark magnetic nanoparticles able to most efficiently convert magnetic energy into heat for magnetic hyperthermia cancer treatment, and their heat losses can be further increased by controlling their assembly through the synthesis of ordered structures. However, achieving the alignment of nanoparticles with one-dimensional chain or columnar structures into long arrays to then study their magnetic heat losses still remains a significant challenge. This study exploits silver nanowires as high-surface-area anisotropic templates for the controlled chaining of IONCs. The surfaces of the IONCs were purposely functionalized with polyethyleneimine (IONCs@PEI) and interacted with silver nanowire (AgNW) surfaces via electrostatic attraction. Here, alternating current (AC) magnetometry was employed to compare the heating performance expressed as specific absorption rate values between individually coated IONCs@PEI and AgNWs@IONCs@PEI composites at various magnetic field strengths and frequencies. SAR values reveal that clustering of IONCs on AgNW surfaces improves the heating efficiency at an applied magnetic field strength of 24 kA m-1, regardless of the applied frequencies, with SAR values of AgNWs@IONCs@PEI composites outperforming those of individual IONCs@PEI. Moreover, dynamic hysteresis loops showed that the coercive field of AgNWs@IONCs@PEI increased significantly at 24 kA m-1, indicating the existence of strong magnetic dipolar interactions between nanoparticles. This study shows an innovative approach for guiding the orientation of magnetic nanoparticles using one-dimensional templates to enhance their heating performance.
  • Article
    Development of Self-Assembled Peptide Hydrogels Containing Matrix-Metalloproteinase Degradable Motifs for 3D Lung Cancer Models
    (Royal Society of Chemistry, 2026) Top, Ayben; Sırma Tarım, Burcu; Top, Ayben; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
    Hydrogel-forming peptides, including matrix metalloproteinase (MMP)-degradable motifs, have been employed to investigate cell-extracellular matrix interactions in vitro. However, their potential in 3D cancer models has been explored only in a few studies. In this study, we used modified MMP-2 degradable motifs (VSLRA or ASLRA) in the design of EDP1 (RVSLRADARVSLRADA) and EDP2 (RASLRADARASLRADA) peptide hydrogelators. The peptides self-assembled into nanofibrillar hydrogels with storage moduli between similar to 300 and similar to 400 Pa. MMP-2 degradation properties of the peptides were confirmed, and a slightly higher MMP-2 responsiveness of the EDP1 hydrogel was observed. The hydrogels were used in the encapsulation of A549 lung adenocarcinoma cancer cells and MRC-5 human lung fibroblast cells. The designed hydrogels supported the proliferation of these cells with high viability and induced cluster formation of encapsulated A549 cells similar to that observed with the RADA hydrogel. However, the hydrogel network structure affected the morphology of the migrated cells in the absence of curcumin. The addition of curcumin decreased the migration and invasion of A549 cells, resulting in a round cell morphology independent of the hydrogel matrices. Anticancer drug tests indicated that cell viability after drug treatment was higher in the 3D hydrogels than in 2D cultures. It was also confirmed that the combinational therapy of doxorubicin and curcumin decreased the cell proliferation and colonization to a greater extent compared to doxorubicin monotherapy. Thus, the hydrogels developed in this study can be used for 3D cancer models or other tissue engineering applications as an alternative to the RADA hydrogel by exploiting the MMP-2 degradation properties.
  • Article
    Citation - Scopus: 7
    High-Pressure Structural Studies and Pressure-Induced Sensitisation of 3,4,5-Trinitro
    (Royal Society of Chemistry, 2023) Atceken, N.; Hemingway, J.; Bull, C.L.; Liu, X.; Michalchuk, A.A.L.; Konar, S.; Morrison, C.A.; 01. Izmir Institute of Technology
    Herein we report the first high-pressure study of the energetic material 3,4,5-trinitro-1H-pyrazole (3,4,5-TNP) using neutron powder diffraction and single-crystal X-ray diffraction. A new high-pressure phase, termed Form II, was first identified through a substantial change in the neutron powder diffraction patterns recorded over the range 4.6-5.3 GPa, and was characterised further by compression of a single crystal to 5.3 GPa in a diamond-anvil cell using X-ray diffraction. 3,4,5-TNP was found to be sensitive to initiation under pressure, as demonstrated by its unexpected and violent decomposition at elevated pressures in successive powder diffraction experiments. Initiation coincided with the sluggish phase transition from Form I to Form II. Using a vibrational up-pumping model, its increased sensitivity under pressure can be explained by pressure-induced mode hardening. These findings have potential implications for the safe handling of 3,4,5-TNP, on the basis that shock- or pressure-loading may lead to significantly increased sensitivity to initiation. © 2023 The Royal Society of Chemistry.