PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7645

Browse

Filters

2013 - 201922020 - 20211

Settings

Department: search.filters.department.İzmir Institute of Technology. Chemical EngineeringPublisher: search.filters.publisher.Royal Society of Chemistry

Search Results

Now showing 1 - 3 of 3
  • Article
    Citation - WoS: 16
    Citation - Scopus: 15
    Ultrasound-Assisted Dopamine Polymerization: Rapid and Oxidizing Agent-Free Polydopamine Coatings on Membrane Surfaces
    (Royal Society of Chemistry, 2021) Cihanoğlu, Aydın; Schiffman, Jessica D.; Alsoy Altınkaya, Sacide; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
    Herein, we report a controllable pathway to accelerate the polymerization kinetics of dopamine using ultrasound as a trigger. The use of ultrasound was demonstrated to dramatically accelerate the slow liquid phase reaction kinetics and increase the deposition rate of the polydopamine coating on the surface of polymeric membranes.
  • Article
    Citation - WoS: 22
    Citation - Scopus: 25
    The Endocytic Pathway and Therapeutic Efficiency of Doxorubicin Conjugated Cholesterol-Derived Polymers
    (Royal Society of Chemistry, 2015) Sevimli, Sema; Bulmuş Zareie, Volga; Macmillan, Alexander; Whan, Renee; Kavallaris, Maria; Bulmuş, Volga; Davis, Thomas P.; 03.01. Department of Bioengineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
    Previously synthesized poly(methacrylic acid-co-cholesteryl methacrylate) P(MAA-co-CMA) copolymers were examined as potential drug delivery vehicles. P(MAA-co-CMA) copolymers were fluorescently labelled and imaged in SHEP and HepG2 cells. To understand their cell internalization pathway endocytic inhibition studies were conducted. It was concluded that P(MAA-co-CMA) are taken up by the cells via clathrin-independent endocytosis (CIE) (both caveolae mediated and cholesterol dependent endocytosis) mechanisms. The formation and characterization of P(MAA-co-CMA)-doxorubicin (DOX) nanocomplexes was investigated by fluorescence lifetime imaging microscopy (FLIM), UV-Visible spectroscopy (UV-Vis) and dynamic light scattering (DLS) studies. The toxicity screening between P(MAA-co-CMA)-DOX nanocomplexes (at varying w/w ratios) and free DOX, revealed nanocomplexes to exhibit higher cytotoxicity towards cancer cells in comparison to normal cells. FLIM and confocal microscopy were employed for investigating the time-dependent release of DOX in SHEP cells and the cellular uptake profile of P(MAA-co-CMA)-DOX nanocomplexes in cancer and normal cell lines, respectively. The endocytic pathway of P(MAA-co-CMA)-DOX nanocomplexes were examined in SHEP and HepG2 cells via flow cytometry revealing the complexes to be internalized through both clathrin-dependent (CDE) and CIE mechanisms. The drug delivery profile, reported herein, illuminates the specific endocytic route and therapeutic efficiency of P(MAA-co-CMA)-DOX nanocomplexes strongly suggesting these particles to be promising candidates for in vivo applications.
  • Article
    Citation - WoS: 21
    Citation - Scopus: 23
    Monetite Promoting Effect of Nacl on Brushite Cement Setting Kinetics
    (Royal Society of Chemistry, 2013) Şahin, Erdem; Çiftçioglu, Muhsin; 01. Izmir Institute of Technology
    Brushite forming calcium phosphate cements (CPCs) have received growing interest for scaffold applications due to their high surface area and high bioresorbability. The dehydrated form of brushite, monetite, has a finer microstructure with higher surface area, higher strength and bioresorbability comparable to brushite, making it a viable alternative phase in CPCs. The increase in monetite content of the β-tricalcium phosphate (β-TCP)-monocalcium phosphate monohydrate (MCPM) cement system due to the reduction in its supersaturation upon addition of NaCl to excess setting liquid was investigated kinetically. The relaxation period was monitored by pH-stat titration of the cement solution by 0.1 M NaOH. Monetite growth was achieved in shorter periods at higher NaCl concentrations where the supersaturation gap between brushite and monetite is thought to be narrowed due to high ionic strength in accord with Pitzer's ion interaction model. The brushite/monetite ratio decreased consistently with increasing NaCl concentration in the 3-6 M range.