PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7645

Browse

Filters

2014 - 20173

Settings

Department: search.filters.department.İzmir Institute of Technology. Materials Science and EngineeringInstitution Author: search.filters.institutionAuthor.Zareie, Hadi M.

Search Results

Now showing 1 - 3 of 3
  • Article
    Citation - WoS: 36
    Citation - Scopus: 38
    Effect of Molecular Architecture on Cell Interactions and Stealth Properties of Peg
    (American Chemical Society, 2017) Özer, İmran; Tomak, Aysel; Tomak, Aysel; Baran, Yusuf; Bulmuş, Volga; Baran, Yusuf; Bulmuş Zareie, Volga; 03.01. Department of Bioengineering; 04.03. Department of Molecular Biology and Genetics; 03. Faculty of Engineering; 04. Faculty of Science; 01. Izmir Institute of Technology
    PEGylation, covalent attachment of PEG to therapeutic biomolecules, in which suboptimal pharmacokinetic profiles limiting their therapeutic utility are of concern, is a widely applied technology. However, this technology has been challenged by reduced bioactivity of biomolecules upon PEGylation and immunogenicity of PEG triggering immune response and abrogating clinical efficacy, which collectively necessitate development of stealth polymer alternatives. Here we demonstrate that comb-shape poly[oligo(ethylene glycol) methyl ether methacrylate] (POEGMA), a stealth polymer alternative, has a more compact structure than PEG and self-organize into nanoparticles in a molecular weight dependent manner. Most notably, we show that comb-shape POEGMA promotes significantly higher cellular uptake and exhibits less steric hindrance imposed on the conjugated biomolecule than PEG. Collectively, comb-shape POEGMA offers a versatile alternative to PEG for stealth polymer-biomolecule conjugation applications.
  • Article
    Citation - WoS: 2
    Citation - Scopus: 2
    Structural Changes in a Schiff Base Molecular Assembly Initiated by Scanning Tunneling Microscopy Tip
    (IOP Publishing Ltd., 2016) Tomak, Aysel; Bacaksız, Cihan; Senger, Ramazan Tuğrul; Şahin, Hasan; Hür, Deniz; Tomak, Aysel; Senger, Ramazan Tuğrul; Birer, Özgür; Şahin, Hasan; Zareie, Hadi M.; 03.01. Department of Bioengineering; 04.04. Department of Photonics; 04.05. Department of Pyhsics; 03. Faculty of Engineering; 04. Faculty of Science; 01. Izmir Institute of Technology
    We report the controlled self-organization and switching of newly designed Schiff base (E)-4-((4-(phenylethynyl) benzylidene) amino) benzenethiol (EPBB) molecules on a Au (111) surface at room temperature. Scanning tunneling microscopy and spectroscopy (STM/STS) were used to image and analyze the conformational changes of the EPBB molecules. The conformational change of the molecules was induced by using the STM tip while increasing the tunneling current. The switching of a domain or island of molecules was shown to be induced by the STM tip during scanning. Unambiguous fingerprints of the switching mechanism were observed via STM/STS measurements. Surface-enhanced Raman scattering was employed, to control and identify quantitatively the switching mechanism of molecules in a monolayer. Density functional theory calculations were also performed in order to understand the microscopic details of the switching mechanism. These calculations revealed that the molecular switching behavior stemmed from the strong interaction of the EPBB molecules with the STM tip. Our approach to controlling intermolecular mechanics provides a path towards the bottom-up assembly of more sophisticated molecular machines.
  • Article
    Citation - Scopus: 1
    Charging of Gold/Metal Oxide/Gold Nanocapacitors in a Scanning Electron Microscope
    (IOP Publishing Ltd., 2014) Coutts, Michael J.; Zareie, Hadi M.; Cortie, Michael B.; McDonagh, Andrew Michael; 01. Izmir Institute of Technology
    Triangular parallel-plate nanocapacitors were fabricated by a combination of microsphere lithography and physical vapor deposition. The devices were comprised of a 20 nm layer of dielectric material sandwiched between two 20 nm layers of gold. Dielectric materials with a range of relative permittivities were investigated. Charging of the capacitors was probed in a scanning electron microscope (SEM) by monitoring the change in brightness of the images of the devices as a function of time. The time constants, RC, associated with the charging of the capacitors, were extracted from the SEM grayscale data. The resulting average RC values were 248 ± 27 s for SiO2, 70 ± 8 s for Al2O3, 113 ± 80 s for ZnO and 125 ± 13 s for HfO2. These values are consistent with the anticipated RC values based on the resistivities and permittivities of the materials used in the devices and importantly, were measured without the need to attach any wires or leads.