PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection

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  • Review
    Citation - WoS: 1
    Citation - Scopus: 2
    Organ-On Platforms for Drug Development, Cellular Toxicity Assessment, and Disease Modeling
    (Tubitak Scientific & Technological Research Council Turkey, 2024) Khurram, Muhammad Maaz; Bedir, Erdal; Cinel, Gokturk; Yesil Celiktas, Ozlem; Bedir, Erdal; 03.01. Department of Bioengineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
    Organs-on-chips (OoCs) or microphysiological platforms are biomimetic systems engineered to emulate organ structures on microfluidic devices for biomedical research. These microdevices can mimic biological environments that enable cell-cell interactions on a small scale by mimicking 3D in vivo microenvironments outside the body. Thus far, numerous single and multiple OoCs that mimic organs have been developed, and they have emerged as forerunners for drug efficacy and cytotoxicity testing. This review explores OoC platforms to highlight their versatility in studies of drug safety, efficacy, and toxicity. We also reflect on the potential of OoCs to effectively portray disease models for possible novel therapeutics, which is difficult to achieve with traditional 2D in vitro models, providing an essential basis for biologically relevant research.
  • Article
    Citation - WoS: 3
    Citation - Scopus: 3
    Β-Ketoenamine-linked covalent organic framework for efficient iodine capture
    (Tubitak Scientific & Technological Research Council Turkey, 2024) Büyükçakır, Onur; Büyükçakır, Onur; 04.01. Department of Chemistry; 04. Faculty of Science; 01. Izmir Institute of Technology
    Exploring the materials that effectively capture radioactive iodine is crucial in managing nuclear waste produced from nuclear power plants. In this study, a β-ketoenamine-linked covalent organic framework (bCOF) is reported as an effective adsorbent to capture iodine from both vapor and solution. The bCOF’s high porosity and heteroatom-rich skeleton offer notable iodine vapor uptake capacity of up to 2.51g $g^{–1}$ at 75 °C under ambient pressure. Furthermore, after five consecutive adsorption-desorption cycles, the bCOF demonstrates high reusability performance with significant iodine vapor capacity retention. The adsorption mechanism was also investigated using various ex situ structural characterization techniques, and these mechanistic studies revealed the existence of a strong chemical interaction between the bCOF and iodine. The bCOF also showed good iodine uptake performance of up to 512 mg $g^{–1}$ in cyclohexane with high removal efficiencies. The bCOF’s performance in adsorbing iodine from both vapor and solution makes it a promising material to be used as an effective adsorbent in capturing radioactive iodine emissions from nuclear power plants.