PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7645
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Article Citation - WoS: 4Citation - Scopus: 6Effect of Boramidic Acid Modified Carbon Nanotubes on Neurological, Morphological and Physiological Responses of Zebrafish (danio Rerio) Embryos and Larvae(Elsevier, 2024) Yigit, Aybek; Kokturk, Mine Ko; Yildirim, Serkan; Nazli, Dilek; Kiliccioglu, Metin; Sahin, Ayse; Alak, GoncaThis study aimed to determine the potential toxicological effects of carbon nanotubes (CNTs), their modifications with ethylenediamine (ED) and boric acid (BA) on aquatic organisms. Specifically, the research focused on the morphological, physiological, and histopathological-immuno-histochemical responses in zebrafish (Danio rerio) embryos and larvae, via applying different concentrations of CNTs, CNT-ED, and CNT-ED-BA (Control, 5, 10, and 20 mg/L). The results indicated that 20 mg/L CNT nanoparticles were toxic to zebrafish larvae, with mortality rates increasing with CNT and CNT-ED concentrations, reaching 36.7 % at the highest CNT concentration. The highest dose caused considerable degeneration, necrosis, DNA damage, and apoptosis, as evidenced by histopathological and immunohistochemical tests. In contrast, despite their high concentration, CNT-ED-BA nanoparticles exhibited low toxicity. Behavioral studies revealed that CNT and CNT-ED nanoparticles had a more significant impact on sensory-motor functions compared to CNT-ED-BA nanoparticles. These findings suggest that modifying the nanosurface with boric acid, resulting in boramidic acid, can reduce the toxicity induced by CNT and CNT EDArticle Citation - WoS: 9Citation - Scopus: 8Depression in Older Adults and Its Associations With Sleep and Synaptic Density(Elsevier, 2024) Didikoglu, Altug; Guler, Esin Simge; Turk, Halil Kaan; Can, Kubilay; Erim, Aleyna Nur; Payton, Antony; Maharani, AsriBackground: Depression among older adults is a global concern, contributing to disability and overall illness burden. Understanding its trajectory, associated risk factors, and implications for mortality is essential for effective intervention. Moreover, the relationship between depression, sleep disturbances, and synaptic density in the ageing brain remains complex and poorly understood. Methods: Using data from the University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age cohort, comprising 6375 participants, we conducted comprehensive assessments of depression trajectories using generalized linear mixed models and mortality risks using Cox mixed-effects models. Generalized structural equation modelling was performed to explore longitudinal associations between sleep duration and depression. Lastly, associations between post-mortem synaptic density and depression were investigated. Results: Our findings revealed that depression rates declined until age 80 before increasing again. Depression was associated with a 10 % increased risk of mortality in older adults. Reduced sleep was correlated with depression, and depression measured early in the study predicted future reduced sleep. Post-mortem analysis showed a global reduction in synaptic density associated with depression, particularly pronounced in the frontal lobe. Limitations: Limitations include recall bias, limiting generalizability due to dominantly including White British participants and difficulty in establishing causation between synaptic density and depression. Conclusion: Our study underscores the significance of addressing depression in older adults, not only for mental health but also for mortality risk and neurobiological health. Early detection and intervention strategies are crucial for improving outcomes in elderly populations, potentially mitigating adverse effects on sleep, synaptic density, cognitive health, and longevity.Article Citation - WoS: 2Citation - Scopus: 2Osteoblasts-Derived Exosomes as Potential Novel Communicators in Particle-Induced Periprosthetic Osteolysis(Elsevier, 2024) de Souza, Wanderson; Gemini-Piperni, S.; Ruivo, Carolina; Bastos, Nuno; Almeida, Sofia; Lopes, Daniel; Ribeiro, Ana R.The inflammatory response to wear particles derived from hip prothesis is considered a hallmark of periprosthetic osteolysis, which can ultimately lead to the need for revision surgery. Exosomes (Exos) have been associated with various bone pathologies, and there is increasing recognition in the literature that they actively transport molecules throughout the body. The role of wear particles in osteoblast-derived Exos is unknown, and the potential contribution of Exos to osteoimmune communication and periprosthetic osteolysis niche is still in its infancy. Given this, we investigate how titanium dioxide nanoparticles (TiO2 NPs), similar in size and composition to prosthetic wear particles, affect Exos biogenesis. Two osteoblastic cell models commonly used to study the response of osteoblasts to wear particles were selected as a proof of concept. The contribution of Exos to periprosthetic osteolysis was assessed by functional assays in which primary human macrophages were stimulated with bone-derived Exos. We demonstrated that TiO2 NPs enter multivesicular bodies, the nascent of Exos, altering osteoblast-derived Exos secretion and molecular cargo. No significant differences were observed in Exos morphology and size. However, functional assays reveal that Exos cargo enriched in uPA stimulates macrophages to a mixed M1 and M2 phenotype, inducing the release of pro- and anti-inflammatory signals characteristic of periprosthetic osteolysis. In addition, we demonstrated the expression of uPA in exosomes derived from the urine of patients with osteolysis. These results suggest that uPA can be a potential biomarker of osteolysis. In the future, uPa may serve as a possible non-invasive biomarker to identify patients at risk for peri-implant osteolysis.Article Citation - WoS: 11Citation - Scopus: 12The Effect of Starch Types on Extensional, Linear and Nonlinear Rheological Properties of Starch Cracker Dough(Elsevier, 2024) Berk, Berkay; Cankal, Yadigar Seyfi; Koroglu, Ebru; Yorulmaz, Hilal; Cavdaroglu, Elif; Unluturk, SevcanCracker is a popular snack, and their quality depends on the rheological properties of the dough during production. This study focused on the impact of different starch types (tapioca, corn, and potato) used in the same amount (30 g) on the rheology of starch cracker dough. Various rheological tests were conducted to assess the dough's properties. Linear viscoelastic properties were determined using oscillatory frequency and temperature sweep tests, while the nonlinear viscoelastic behavior was characterized through stress relaxation and creep recovery tests. Extensional rheological behavior was also examined. Additionally, the textural and thermal properties of the dough were monitored to understand starch gelatinization and its interactions with other components. In the linear viscoelastic region, no significant differences were found between different dough formulations. However, in the nonlinear viscoelastic region, the potato starch-containing formulation exhibited different viscoelastic and textural properties. Biaxial extensional rheological behaviors showed no significant variations between formulations. The temperature sweep test data from differential scanning calorimetry measurements were consistent with temperature sweep data. In summary, this study provides valuable insights into how different starches influence the rheological behavior of starch cracker dough, considering various degrees of deformation and temperature. These findings have implications for cracker production parameters.Article Citation - WoS: 1Citation - Scopus: 1Canine Oocyte Nuclear Maturation With Nano-Ozone (nzs) Supplementation: the Alterations of Antioxidant, and Oxidant Status and Cdk1, Cyclin B1 Expressions(Elsevier, 2024) Bari, O.; Sabanci, A. U.; Avci, G.; Bozkurt, B.; Ustuner, B.; Denk, B.; Ozalp, G. R.This study aims to evaluate the effects of nano-ozone solution (NZS) on canine oocyte nuclear maturation, associated with the alterations of antioxidant and oxidant status and cyclin-dependent kinase 1 (CDK1), cyclin B1 gene expressions. Oocytes were cultured in four distinct concentrations of NZS (0.5, 1, 2, and 5 mu g/mL) and parthenogenetically activated. The rates of oocytes arrested at the Germinal Vesicle (GV), Germinal Vesicle Breakdown (GVBD), Metaphase I (MI), and Metaphase II (MII) stages were statistically different among groups (P < 0.05). The oocytes cultured in 1 <mu>g/mL NZS yielded the best oocyte maturation rate at the MI and MII stages; however, the lowest maturation and high degeneration rates were observed in Group E. The measurements of Malondialdehyde (MDA), reduced Glutathione (GSH), Superoxide Dismutase (SOD), and Ferric Reducing/Antioxidant Power assay (FRAP) were performed from IVM culture media. No statistical difference was observed in SOD and MDA results (P > 0.05). GSH levels were statistically significant between Group AGroup E (p = 0.003), Group B-Group E (p = 0.045), and Group E-Group D (p = 0.021). The culture media in Group D and Group E had high FRAP concentrations and significantly differed between groups (P < 0.05). CDK1, and cyclin B1 genes, which are subunits of maturation-promoting factor (MPF), are upregulated in Group B and Group C, while are downregulated in oocytes of Group E. This study showed that low, controlled doses of NZS (1 <mu>g/mL) supplementation could improve the meiotic competence of canine oocytes and lead to positive response in expressions of CDK1 and cyclin B1 on the gene level.Article Citation - WoS: 11Citation - Scopus: 11Renewable-Based Treatment Solution of Reactive Blue 21 Dye on Fly Ash as Low-Cost and Sustainable Adsorbent(Elsevier, 2024) Kobya, Mehmet; Dolaz, Mustafa; Goren, Aysegul YagmurThis study investigated the removal of Reactive Blue 21 (RB 21) dye from aqueous solutions by adsorption, evaluating the waste fly ash (FA). The effects of the parameters, such as initial dye concentration (100-750 mg/ L), initial pH (2.0-8.0), adsorbent dose (1.0-4.0 g/L), and temperature (298-323 K) on the adsorption process were investigated. The optimum initial pH value was 2.0 for the highest RB21 dye removal (75.2 mg/g). At optimized conditions (pH 2.0, an adsorbent dosage of 1.0 g/L, a dye concentration of 750 mg/L, and an equilibrium time of 72 h), the highest adsorption capacity was found to be 105.2 mg/g. Moreover, the results of the kinetic studies fitted the pseudo-second-order kinetic model. Equilibrium data were best represented by the Langmuir isotherm model, with a maximum monolayer adsorption capacity of 103.41 mg/g at 323 K. Delta G0ads values were negative and varied from 11.64 to 9.50 kJ/mol in the temperature range of 298-323 K, the values of enthalpy (Delta Ho ads) and entropy (Delta So ads) of thermodynamics parameters were calculated as 37.62 kJ/mol and 86.67 J/mol K, respectively, indicating that this process was endothermic. Furthermore, the adsorbent costs for powdered activated carbon (PAC) and FA to remove 1 kg of RB 21 dye from aqueous solutions are calculated as 2.52 U.S. $ and 0.34 U.S. $, respectively. It is seen that the cost of FA is approximately 7.4 times lower than PAC. The results showed that FA, a low-cost industrial waste, was promising for the adsorption of RB 21 from aqueous solutions.Review Citation - WoS: 22Citation - Scopus: 30Comparative Environmental Sustainability Assessment of Biohydrogen Production Methods(Elsevier, 2023) Goren, A. Yagmur; Dincer, Ibrahim; Khalvati, Ali; Gören, Ayşegül Yağmur; Dinçer, İbrahimAs energy crisis is recognized as an increasingly serious concern, the topic on biohydrogen (bioH(2)) production, which is renewable and eco-friendly, appears to be a highly-demanding subject. Although bioH(2) production technologies are still at the developmental stage, there are many reported works available on lab- and pilot-scale systems with a promising future. This paper presents various potential methods of bioH(2) production using biomass resources and comparatively assesses them for environmental impacts with a special emphasis on the specific biological processes. The environmental impact factors are then normalized with the feature scaling and normalization methods to evaluate the environmental sustainability dimensions of each bioH(2) production method. The results reveals that the photofermentation (PF) process is more environmentally sustainable than the other investigated biological and thermochemical processes, in terms of emissions, water-fossil-mineral uses, and health issues. The global warming potential (GWP) and acidification potential (AP) for the PF process are then found to be 1.88 kg-CO2 eq. and 3.61 g-SO2 eq., which become the lowest among all processes, including renewable energy-based H-2 production processes. However, the dark fermentation-microbial electrolysis cell (DF-MEC) hybrid process is considered the most environmentally harmful technique, with the highest GWP value of 14.6 kg-CO2 eq. due to their superior electricity and heat requirements. The water conception potential (WCP) of 84.5 m(3) and water scarcity footprint (WSF) of 3632.9 m(3) for the DF-MEC process is also the highest compared to all other processes due to the huge amount of wastewater formation potential of the system. Finally, the overall rankings confirm that biological processes are primarily promising candidates to produce bioH(2) from an environmentally friendly point of view.