PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7645
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Article Citation - WoS: 2Citation - Scopus: 2A Deterministic and Stochastic Assessment for Exposure and Risk of Arsenic Via Ingestion of Edible Crops(Springer Verlag, 2019) Can Terzi, Begüm; Gündüz, Orhan; Sofuoğlu, Sait CemilNatural arsenic contamination is a critical problem for various places around the world. Simav Plain (Kutahya, Turkey) is one such area that was shown to have natural arsenic contamination in its waters and soils. Arsenic exposure through ingestion of edible crops cultivated in Simav Plain and associated health risks were assessed in this study. To achieve this objective, arsenic levels in 18 crop species were estimated based on measured soil arsenic concentrations. Individual and aggregate non-carcinogenic and carcinogenic risks associated with ingestion of arsenic-contaminated crops were then assessed with scenario-based deterministic point estimates and stochastic population estimates. Monte Carlo simulation was used for the estimation of population health risks. Accordingly, wheat was found as the highest-ranked crop specie for the both types of health risks, followed by tomato and potato, which are three of the most consumed crops in the region. The risk levels estimated in this study were relatively high, indicating consumption of crops grown in the plain may be posing significant health risks even at lower-bound estimates. Consuming wheat, tomato, potato, and their products from uncontaminated sources was found to reduce the aggregate risks up to 88% implicating the importance of proposing suitable management measures for similar risk-prone areas.Article Citation - WoS: 36Citation - Scopus: 42Speciated Arsenic Concentrations, Exposure, and Associated Health Risks for Rice and Bulgur(Elsevier Ltd., 2014) Sofuoğlu, Sait Cemil; Güzelkaya, Hilal; Akgül, Özlem; Kavcar, Pınar; Kurucaovalı, Filiz; Sofuoğlu, AysunArsenic species were determined in rice and bulgur samples that were collected from 50 participants who also supplied exposure related information through a questionnaire survey. Speciation analysis was conducted using an HPLC-ICP-MS system. Ingestion exposure to arsenic and associated health risks were assessed by combining the concentration and questionnaire data both for individual participants and the subject population. Inorganic arsenic dominated both in rice and bulgur but concentrations were about an order of magnitude higher in rice (160. ±. 38. ng/g) than in bulgur. Because participants also consumed more rice than bulgur, exposures were significantly higher for rice resulting in carcinogenic risks above acceptable level for 53% and 93% of the participants when the in-effect and the proposed potencies were used, respectively, compared to 0% and 5% for bulgur. An inorganic arsenic standard for rice would be useful to lower the risks while public awareness about the relation between excessive rice consumption and health risks is built, and bulgur consumption is promoted.Article Citation - WoS: 303Citation - Scopus: 336A Health Risk Assessment for Exposure To Trace Metals Via Drinking Water Ingestion Pathway(Elsevier Ltd., 2009) Kavcar, Pınar; Sofuoğlu, Aysun; Sofuoğlu, Sait CemilA health risk assessment was conducted for exposure to trace metals via drinking water ingestion pathway for Province of İzmir, Turkey. Concentrations of 11 trace metals were measured in drinking waters collected from 100 population weighted random sampling units (houses). The samples were analyzed in atomic absorption spectrometry for arsenic, and inductively coupled plasma-optical emission spectrometry for Be, Cd, Co, Cr, Cu, Mn, Ni, Pb, V, and Zn. Questionnaires were administered to a participant from each sampling unit to determine drinking water consumption related information and demographics. Exposure and risks were estimated for each individual by direct calculation, and for İzmir population by Monte Carlo simulation. Six trace metals (As, Cr, Cu, Mn, Ni, and Zn) were detected in >50% of the samples. Concentrations of As and Ni exceeded the corresponding standards in 20% and 58% of the samples, respectively. As a result, arsenic noncarcinogenic risks were higher than the level of concern for 19% of the population, whereas carcinogenic risks were >10-4 for 46%, and >10-6 for 90% of the population.Article Citation - WoS: 104Citation - Scopus: 115An Exposure and Risk Assessment for Fluoride and Trace Metals in Black Tea(Elsevier Ltd., 2008) Sofuoğlu, Sait Cemil; Kavcar, PınarExposure and associated health risks for fluoride and trace metals in black tea were estimated. Fifty participants were randomly recruited to supply samples from the tea that they drink, and self-administer a questionnaire that inquired about personal characteristics and daily tea intake. Analyzed trace metals included aluminum, arsenic, barium, cadmium, cobalt, chromium, copper, manganese, nickel, strontium, and zinc. Fluoride and four metals (Al, Cr, Mn, Ni) were detected in all samples while barium was detected only in one sample. The remaining metals were detected in >60% of the samples. Fluoride and aluminum levels in instant tea bag samples were greater than in loose tea samples (p < 0.05) while the differences in elemental concentrations of loose and pot bag tea samples were not significant. Median and 90th percentile daily tea intake rates were estimated as 0.35 and 1.1 l/day, respectively. Neither fluoride nor aluminum levels in black tea were found to associate with considerable risks of fluorosis and Alzheimer's disease, respectively. However, carcinogenic risk levels for arsenic were high; R > 1.0 × 10-6 even at the median level. According to sensitivity analysis, daily tea intake was the most influencing variable to the risk except for arsenic for which the concentration distribution was of more importance.