Food Engineering / Gıda Mühendisliği

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  • Conference Object
    Decision Making on Postmastectomy Radiation Therapy for Patients With T3n0m0 Luminal Breast Cancer
    (Springer, 2023) King, Caleb; Vargo, John; Bhargava, Rohit; Diego, Emilia J.; Cowher, Michael; Johnson, Ronald; Sezgin, Efe
    [No abstract available]
  • Conference Object
    Locoregional Treatment Improves Survival in De Novo Bone-Only Metastatic Breast Cancer: Long-Term Results of the Prospective, Multi-Institutional Study - Protocol Bomet Mf14-01
    (Springer, 2023) Soran, Atilla; Doğan, Lütfi; Işık, Arda; Özbaş, Serdar; Can Trabulus, Didem; Demirci, Umut; Karanlık, Hasan; Sezgin, Efe
    [No abstract available]
  • Article
    Citation - WoS: 6
    Citation - Scopus: 6
    Organosolv Pretreatment of Corncob for Enzymatic Hydrolysis of Xylan
    (Springer, 2023) Büyükkileci, Ali Oğuz; Temelli, Nuran
    Xylan is a renewable polysaccharide, readily available in agricultural and forestry residues. It can be hydrolyzed to produce xylooligosaccharides (XOS) with prebiotic activity and xylose, a precursor for several industrial chemicals. Enzymatic hydrolysis of xylan in the lignocellulosic biomass to obtain xylose and XOS requires a pretreatment to facilitate xylanase activity. In this study, organosolv was evaluated for the delignification of corncob while retaining xylan in the pretreated biomass. The treatment at 170 °C for 1 h with 70% ethanol provided 50% lignin removal and 81% xylan recovery. Increasing temperatures and decreasing ethanol fractions decreased the pH and the xylan recovery. Loss of xylan in the organosolv at 190 °C and in the liquid hot water treatment could be prevented by the addition of 100 mM MgO, without compromising lignin removal. Pretreated corncob was suspended in citrate buffer and hydrolyzed by commercial xylanases. Accellerase XY (250 U/ml) at pH 5.5 and 55 °C and Econase XT (0.6 U/ml) at pH 6.0 and 70 °C provided around 65% xylan digestibility and generated xylose (9.8 g/l) and XOS (10.9 g/l), respectively. This approach could decrease xylan loss and degradation in the pretreatment step and yield clear hydrolysates composed of essentially xylose or XOS. Lignocellulosic biorefineries can benefit from the efficient utilization of xylan, increasing sustainability. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
  • Book Part
    Citation - WoS: 10
    Exopolysaccharides in Food Processing Industrials
    (Springer, 2021) Arserim-Uçar, Dilhun Keriman; Konuk Takma, Dilara; Korel, Figen
    Microbial exopolysaccharides are a class of extracellular carbohydrates based on biopolymeric materials produced and secreted by bacteria, yeast, molds, and microalgae. Cellulose, pullulan, xanthan gum, dextran, kefiran, curdlan, emulsan, alginate, gellan, carrageenans, hyaluronic acid, levan, colanic acid, welan, glucuronides, succinoglycans, and mutan are the exopolysaccharides (EPSs) of different microbial origin. Most of the available EPSs are non-toxic, biocompatible, biodegradable, and obtain from renewable resources. Microbial EPSs display unique functional properties due to their nature and structural composition. The demand for natural microbial EPSs utilization in the food industry due to their unique properties, including emulsifier, gelling agent, and stabilizers. Microbial EPSs and their derivatives have found a wide range of applications in food systems, including fermented dairy products, bakery products, cereal-based products, beverages, delivery of active agents, coatings, and films. This chapter will present a comprehensive overview of the recent developments of EPSs and their potential utilization in the food industry.
  • Article
    Citation - WoS: 63
    Citation - Scopus: 63
    The Effect of Primary Surgery in Patients With De Novo Stage Iv Breast Cancer With Bone Metastasis Only (protocol Bomet Mf 14-01): a Multi-Center, Prospective Registry Study
    (Springer, 2021) Soran, Atilla; Doğan, Lütfi; Işık, Arda; Özbaş, Serdar; Trabulus, Didem Can; Demirci, Umut; Sezgin, Efe
    Background More evidence shows that primary surgery for de novo metastatic breast cancer (BC) prolongs overall survival (OS) in selected cases. The aim of this study was to evaluate the role of locoregional treatment (LRT) in BC patients with de novo stage IV bone only metastasis (BOM). Methods The prospective, multicenter registry study BOMET MF14-01 was initiated in May 2014. Patients with de novo stage IV BOM BC were divided into two groups: those receiving systemic treatment (ST group) and those receiving LRT (LRT group). Patients who received LRT were further divided into two groups: ST after LRT (LRT + ST group) and ST before LRT (ST + LRT group). Results We included 505 patients in this study; 240 (47.5%) patients in the ST group and 265 (52.5%) in the LRT group. One hundred and thirteen patients (26.3%) died in the 34-month median follow-up, 85 (35.4%) in the ST group and 28 (10.5%) in LRT group. Local progression was observed in 39 (16.2%) of the patients in the ST group and 18 (6.7%) in the LRT group (p = 0.001). Hazard of death was 60% lower in the LRT group compared with the ST group (HR 0.40, 95% CI 0.30-0.54, p < 0.0001). Conclusion In this prospectively maintained registry study, we found that LRT prolonged survival and decreased locoregional recurrence in the median 3-year follow-up. Timing of primary breast surgery either at diagnosis or after ST provided a survival benefit similar to ST alone in de novo stage IV BOM BC patients.
  • Article
    Citation - WoS: 13
    Citation - Scopus: 14
    Uv-Vis Spectroscopy for the Estimation of Variety and Chemical Parameters of Olive Oils
    (Springer, 2021) Jolayemi, Olusola Samuel; Tokatlı, Figen; Özen, Banu
    Olive oils produced in different years from different varieties were studied with UV-Vis spectroscopy for classification and prediction. Multivariate models were created with second derivative spectral data, and tested with external validation sets. For varietal classification, orthogonal partial least square discriminant analysis resolved oil samples into various classes with correct classification rate more than 89% for validation set (n = 20). A sample of fresh and stored oils were also classified with a correct classification rate more than 90% for validation set (n = 20). In the predictions of chemical parameters (70 for calibration, 30 for validation), the combination of UV-Vis spectroscopy with orthogonal partial least square regression models showed potential for simultaneous quantification of chlorophylls (0.6-5.6 mg/kg; R-val(2) , 0.79; RPD, 1.97); carotenoids (0.6-3.3 mg/kg; R-val(2), 0.80; RPD, 2.38); ratio of mono to polyunsaturated fatty acids (3.6-8.8; R-val(2) , 0.77; RPD, 1.90), oleuropein derivatives (1.2-62.3 mg/kg; R-val(2) , 0.66; RPD, 1.77), and total phenol content (62.2-505 mg/kg; R-val(2) , 0.67; RPD, 1.74), although showed poor to moderate results for the quantification of free fatty acid (0.3-5.4%; R-val(2), 0.67; RPD, 1.64); monounsaturated fatty acids (66-76.5%; R-val(2) , 0.71; RPD, 1.67); polyunsaturated fatty acids (8.6-18.2%; R-val(2) , 0.73; RPD, 1.65). The models were unable to estimate oxidative stability, saturated fatty acids, and individual phenolics such as hydroxytyrosol, pinoresinol, luteolin, total phenolic acids (R-val(2) , 0.26-0.64; RPD, 0.60-1.52). Results showed the capacities of UV-Vis spectroscopy for classification of olive oils, and prediction of total pigments and phenol content and ratio of mono to polyunsaturated fatty acids.