Food Engineering / Gıda Mühendisliği

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Author: search.filters.author.An, PingPublisher: search.filters.publisher.Nature Research

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  • Article
    Citation - WoS: 5
    Citation - Scopus: 3
    Apol1 Variant Alleles Associate With Reduced Risk for Opportunistic Infections in Hiv Infection
    (Nature Research, 2021) An, Ping; Sezgin, Efe; Kirk, Gregory D.; Duggal, Priya; Binns-Roemer, Elizabeth; Nelson, George; Limou, Sophie
    Apolipoprotein L1 (APOL1), an innate immune factor against African trypanosoma brucei, inhibits HIV-1 in vitro. The impact of APOL1 G1-G2 variants on HIV-1-associated opportunistic infections (OIs) is unknown. Here, we report findings from a metaanalysis of four HIV/AIDS prospective cohorts (ALIVE, LSOCA, MACS, and WIHS) including 2066 African American participants. Using a global test combining all four cohorts, carriage of two APOL1 variant alleles is associated with a 50% reduction in odds of OI (combined OR 0.50, 95% CI 0.33-0.76). Subgroup analysis of OI etiological categories (viral, parasitic, fungal and Mycobacterial) suggests the possibility of specific protection from fungal infections (OR 0.54. 95% CI 0.32-0.93; P-Bonferroni corrected=0.08). We observe an association of APOL1 variant alleles with host protection against OI in HIV-positive individuals. The study suggests a broader role of APOL1 variant alleles in innate immunity in vivo. An et al. determine the presence of variants of the innate immune factor APOL1 in four cohorts of HIV-positive patients. The study suggests that APOL1 might confer carriers of two variant alleles protection from HIV related opportunistic infections, especially fungal infections.