Food Engineering / Gıda Mühendisliği
Permanent URI for this collectionhttps://hdl.handle.net/11147/12
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Article Evrimsel epidemiyoloji: Epidemiyoloji ve evrimsel biyolojinin sentezi(Türk Tabipleri Birliği, 2016) Sezgin, EfeEpidemiology investigates the distribution and causes of health and disease among individuals and populations. Evolutionary medicine, in other words Darwinian medicine, is a new discipline that aims to bring novel approaches to health problems that traditional medicine cannot understand and cannot find cures for, in order to improve the overall health of human populations. Epidemiology, the primary discipline of public health, is one of the medical branches that benefited the most from evolutionary approaches in medicine. Traditional epidemiology focuses on proximate causes and seeks answers to 'what' and 'how' questions on the dynamics between factors, environment, and humans. Evolutionary epidemiology focuses on the ultimate causes of diseases and seeks answers to 'how' and 'why' questions on the origin and function. In order to find answers, it compares the evolutinary process of Homo sapiens (modern humans) with that of its relatives, it examines the fast changes in human ecology, demographic and social dynamics, it looks at the epidemiology of modern diseases from an evolutionary process perspective. Using contemporary molecular and statistical genetic methods, it examines the contemporary human genetic variation and its evolution. It searches why diseases causing genetic variation are still not eliminated from human populations. Adaption of evolutionary ideas into epidemiologic research will enhance population health and provide novel solutions for diseases.Article Evrimsel Tıp: Sağlık ve Hastalıklara Yeni Yaklaşımlar(2016) Sezgin, EfeEvrimsel tıp, günümüz hastalıklarına geneksel tıbbın "yaklaşık" nedenlemelerinin yanı sıra "nihai" nedenleme ile farklı bir bakış açısı getirmeyi amaçlar. Klasik tıp hastalıkların yapı ve mekanizmalar hakkında "Ne" ve "Nasıl" sorularına cevap ararken, evrimsel tıp köken ve fonksiyon hakkında "Neden" ve "Niçin" sorularına cevap arar. Evrimsel analizlerde kullanılan molküler evrim, popülasyon genetiği, filogenetik gibi metodları günümüz hastalıklarının köken ve sebeplerini anlamak için uygular. Evrimsel tıp tüm sağlık bilimlerine farklı bakış açıları getirmeyi, günümüz yaklaşımlarıyla çözüm bulamadığımız, sebebini anlayamadığımız sorunların çözümüne katkıda bulunmayı amaçlan yeni bir disiplindir.Article Citation - WoS: 1Is Routine Histopathological Gallbladder Examination Necessary After Cholecystectomy? Evaluation of the Results of 1366 Cholecystectomy Specimens in Single Center(Düzce Üniversitesi, 2017) Uysal, Erdal; Sezgin, Efe; Bakır, Hasan; Gürer, Ahmet; Sökücü, MehmetObjective: It was aimed to evaluate the results of routine histopathological examination after cholecystectomy and to investigate the necessity of routine histopathologic examination after cholecystectomy. Methods: The study was designed retrospectively. One thousand three hundred sixty six patients who underwent laparoscopic and open cholecystectomy at Private Sani Konukoglu Hospital with pre-diagnosis of benign gallbladder disease between November 2011 and May 2017 were included in the study. Patients' demographic data, pathologic results, macroscopic appearance of the specimen, and cancer staging were recorded. The distribution and frequency of pathologic diagnoses and the prevalence of incidental gallbladder cancer (GBC) were evaluated. Pathologic findings were compared in terms of age groups and gender relations. Results: The number of patients included in the study was 1366. Diagnosed with chronic cholecystitis patients were 1,303 (95%), 39 (3%) with acute cholecystitis, 7 (0.5%) with gallbladder cancer, and 17 (1.5%) with other diagnoses of the patients. Statistical significance was found between the groups in terms of the mean age (p = 0.0002). Comparisons between groups in terms of cholesterolysis were statistically significant (p = 0.0003). There was a significant relationship between mucosa atrophy and gender (p = 0.001). Conclusions: The histopathological spectrum of gallbladder is quite extensive. Incidental GBC may not be detected by preoperative imaging methods. Incidental GBC are usually asymptomatic. T2, T3 and T4 GBC were also encountered in our study. All of these patients need additional operations. In the absence of routine histopathologic examination, metastatic advanced GBC may be encountered because no treatment plans could make. Thus, we do recommend routine histopathological examination.