Dizmen, Berivan

Profile URL
https://hdl.handle.net/11147/16295
Name Variants
Job Title
Email Address
Main Affiliation
01. Izmir Institute of Technology
Status
External
Website
ORCID ID
0000-0001-7831-0795
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
HOX-2132-2023

Sustainable Development Goals

NO POVERTY1
NO POVERTY
0
Research Products
ZERO HUNGER2
ZERO HUNGER
0
Research Products
GOOD HEALTH AND WELL-BEING3
GOOD HEALTH AND WELL-BEING
1
Research Products
QUALITY EDUCATION4
QUALITY EDUCATION
0
Research Products
GENDER EQUALITY5
GENDER EQUALITY
0
Research Products
CLEAN WATER AND SANITATION6
CLEAN WATER AND SANITATION
1
Research Products
AFFORDABLE AND CLEAN ENERGY7
AFFORDABLE AND CLEAN ENERGY
0
Research Products
DECENT WORK AND ECONOMIC GROWTH8
DECENT WORK AND ECONOMIC GROWTH
0
Research Products
INDUSTRY, INNOVATION AND INFRASTRUCTURE9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
1
Research Products
REDUCED INEQUALITIES10
REDUCED INEQUALITIES
0
Research Products
SUSTAINABLE CITIES AND COMMUNITIES11
SUSTAINABLE CITIES AND COMMUNITIES
0
Research Products
RESPONSIBLE CONSUMPTION AND PRODUCTION12
RESPONSIBLE CONSUMPTION AND PRODUCTION
0
Research Products
CLIMATE ACTION13
CLIMATE ACTION
1
Research Products
LIFE BELOW WATER14
LIFE BELOW WATER
1
Research Products
LIFE ON LAND15
LIFE ON LAND
0
Research Products
PEACE, JUSTICE AND STRONG INSTITUTIONS16
PEACE, JUSTICE AND STRONG INSTITUTIONS
0
Research Products
PARTNERSHIPS FOR THE GOALS17
PARTNERSHIPS FOR THE GOALS
0
Research Products
This researcher does not have a Scopus ID.
WoS data could not be loaded because of an error. Please refresh the page or try again later.
No records found in other affiliations.
Scholarly Output

3

Articles

1

Views / Downloads

1256/472

Supervised MSc Theses

1

Supervised PhD Theses

0

WoS Citation Count

1

Scopus Citation Count

0

Patents

0

Projects

0

WoS Citations per Publication

0.33

Scopus Citations per Publication

0.00

Open Access Source

2

Supervised Theses

1

JournalCount
Planta Medica1
Records of Natural Products1
Current Page: 1 / 1

Scopus Quartile Distribution

Competency Cloud

GCRIS Competency Cloud
Author of Publication: search.filters.isAuthorOfPublication.16b8bad2-f2cd-4ca5-ab1f-c1c63929b520

Scholarly Output Search Results

Now showing 1 - 3 of 3
  • Article
    Anthraquinones and Macrocyclic Lactones From Endophytic Fungus Penicillium Roseopurpureum and Their Bioactivities
    (ACG Publications, 2024) Dizmen,B.; Üner, Göklem; Küçüksolak, Melis; Dizmen, Berivan; Bedir, Erdal; Kırmızıbayrak,P.B.; Bedir,E.; 01. Izmir Institute of Technology; 03.01. Department of Bioengineering; 03. Faculty of Engineering
    Endophytic fungi colonize the internal and distinct tissues of the host plants. In recent years, there has been growing interest in endophytic fungi as valuable sources for drug discovery based on their rich metabolic profiles consisting of novel and bioactive compounds. Accordingly, our preliminary study demonstrated that an endophyte, namely Penicillium roseopurpureum isolated from Astragalus angustifolius, had high chemical diversity with an antiproliferative effect. Herein, fermentation of P. roseopurpureum resulted in the production of five new anthraquinone-type compounds (2, 4, 6, 7, 8) together with several known compounds [11-methoxycurvularin (1: epimeric mixture of 1a and 1b), carviolin (3), 11-hydroxycurvularin (5: diastereoisomeric mixture of 5a and 5b) and 1-O-methylemodin (9)]. The structures of the new compounds were established by NMR spectroscopy and HR-MS analysis. Cytotoxicity studies demonstrated that none of the compounds except for 1 and 5 had antiproliferative activity against prostate cancer cell lines. Interestingly, 1 was found as cytotoxic, whereas 5 exhibited cytostatic properties. Also, 7-AAD/Annexin V staining supported these results by showing that 1 caused cellular death, while 5 did not show any increase in dead cell content in comparison to the control. Lastly, cell cycle analysis showed that compounds had distinctive cell cycle arrest patterns. © 2024 ACG Publications.
  • Conference Object
    Citation - WoS: 1
    Secondary Metabolites From Endophytic Fungus Penicilium Roseopurpureum and Investigation of Their Cytotoxic Activities
    (Georg Thieme Verlag, 2022) Dizmen, Berivan; Dizmen, Berivan; Üner, Göklem; Bedir, Erdal; Küçüksolak, Melis; Üner, Göklem; Ballar Kırmızıbayrak, Petek; Küçüksolak, Melis; Bedir, Erdal; 03.01. Department of Bioengineering; 01. Izmir Institute of Technology; 03. Faculty of Engineering
    [No Abstract Available]
  • Master Thesis
    Investigation on the Bioactive Secondary Metabolites of the Endophytic Fungus Penicillium Roseopurpureum
    (01. Izmir Institute of Technology, 2022) Dizmen, Berivan; Bedir, Erdal; Bedir, Erdal; 01. Izmir Institute of Technology; 03.01. Department of Bioengineering; 03. Faculty of Engineering
    In recent years, endophytic fungi have been considered as significant resources of new bioactive secondary metabolites, so they are predicted to have an important impact in drug discovery and development. In our preliminary study, the chemical diversity and cytotoxic activity of an endophytic fungus, namely Penicilium roseopurpureum 1E4BS1 isolated from Astragalus angustifolius, have been demonstrated. Based on these data, it was aimed to obtain bioactive secondary metabolites of P. roseopurpureum 1E4BS1 within the scope of this thesis. Firstly, a fermentation study was carried out in a rotary shaker at 180 rpm, 25 ºC for 20 days, and the obtained broth was extracted with EtOAc. Secondly, nine metabolites were isolated from the EtOAc extract by chromatographic methods, and the structures of compounds were elucidated by spectral methods (1D-, 2D NMR, and MS). The structure elucidation studies revealed that seven metabolites had anthraquinone backbone, whereas two compounds were found to be derivatives of curvularin from macrolide group. A chemical structure search confirmed that five of the metabolites were new for nature. Cytotoxic activity of the compounds and the EtOAc extract was tested against three cancer (DU145, LnCaP, and PC3) and normal (RPWE-1) cell lines by MTT cell viability assay. The metabolite PR-EB-01 exhibited the highest activity with IC50 values of 26.0, 37.2, 24.7, and 30.9 μM against LNCaP, PC3, DU145, and RPWE-1 cells, respectively.